Qhov txawv ntawm CRP thiab homocysteine yog tias C reactive protein (CRP) yog pentameric protein thaum homocysteine yog non-proteinogenic alpha amino acid.
Kev mob plab yog ib qho kev lom zem teb uas tsim los tawm tsam ntau yam teeb meem xws li cov kab mob, cov hlwb puas hauv lub cev, lossis ua rau khaus. Nws suav nrog cov tshuaj tiv thaiv kab mob, cov tshuaj molecular mediators thiab cov hlab ntsha. Tsis tas li ntawd, cov cim sib txawv qhia tau tias muaj kev mob tshwm sim. Yog li ntawd, cov cim no yog siv nyob rau hauv kev kho mob theem los txheeb xyuas cov kab mob sib txawv uas muaj feem xyuam rau o. C reactive protein (CRP) thiab homocysteine yog ob yam cim.
CRP yog dab tsi?
C Reactive Protein (CRP) yog pentameric protein muaj nyob rau hauv cov ntshav plasma. Nws yog ib tug tswv cuab ntawm pentraxins protein tsev neeg nrog ib tug monomer ntawm 224 amino acids. Molecular mass ntawm CRP yog 25,106 Da. Cov noob uas encodes CRP protein muaj nyob rau ntawm chromosome 1. Tsis tas li ntawd, cov qib CRP nce siab heev hauv kev teb rau qhov mob. Tsis tas li ntawd, CRP synthesis tshwm sim hauv lub siab hauv kev teb rau cov cim qhia tawm los ntawm macrophages thiab adipocytes thaum muaj mob.
Tsis tas li ntawd, CRP yog ib qho mob hnyav ntawm cov kab mob siab. Qhov nce hauv qib CRP tshwm sim vim qhov tso tawm ntawm interleukin-6 los ntawm T lymphocytes thiab macrophages. Li no, thawj tus qauv lees paub receptor (PRR) tau txheeb xyuas thaum mob yog CRP.
Daim duab 01: CRP
Dhau li ntawm, lub luag haujlwm ntawm lub cev ntawm CRP cuam tshuam nrog kev khi rau lysophosphatidylcholine, uas muaj nyob rau ntawm qhov chaw tuag lossis cov hlwb tuag. Thaum ua tiav, nws qhib txoj hauv kev ntxiv los ntawm kev sib xyaw ua ke 1q (C1q). Yog li, qhov no txhawb nqa phagocytosis los ntawm macrophages thiab tshem tawm cov hlwb apoptotic, necrotic hlwb, thiab cov kab mob.
Homocysteine yog dab tsi?
Homocysteine yog ib qho uas tsis yog-proteinogenic alpha amino acid, uas yog homologue ntawm cysteine amino acid nrog ib qho ntxiv methylene choj. Lub cev tsis tuaj yeem tau txais homocysteine los ntawm kev noj haus. Yog li, biosynthesis ntawm homocysteine tshwm sim los ntawm ntau cov txheej txheem los ntawm methionine nrog kev tshem tawm ntawm cov pa roj carbon methyl pawg. Los ntawm cov vitamins B, homocysteine muaj peev xwm hloov rov qab mus rau methionine lossis cysteine nyob ntawm qhov xav tau.
Tsis tas li ntawd, qhov txawv txav ntawm homocysteine ua rau ntau yam kab mob. Kev nce qib ntawm homocysteine ib txwm ua rau hyperhomocysteineemia. Thiab, tus kab mob no ua rau cov kab mob endothelial raug mob. Nws ua rau cov hlab ntsha o thiab hloov mus rau atherogenesis. Thaum kawg, nws ua rau ischemic raug mob (txhim kho cov ntshav mus rau cov ntaub so ntswg). Yog li, hyperhomocysteine muag ua rau muaj kev pheej hmoo rau kab mob plawv. Nws tshwm sim vim thaiv cov ntshav ntws mus rau cov hlab ntsha ntawm cov hlab ntsha los ntawm atherosclerotic plaque. Yog li, qhov no txwv tsis pub cov ntshav oxygenated rau lub plawv.
Daim duab 02: Homocysteine
Muaj kev sib raug zoo ntawm hyperhomocysteineemia thiab tshwm sim ntawm mob stroke, plawv nres, thiab ntshav txhaws. Txawm li cas los xij, nws tseem tsis tau paub meej tias hyperhomocysteineemia yog ib qho kev pheej hmoo ntawm tus kab mob no. Tsis tas li ntawd, thaum ntxov cev xeeb tub poob thiab neural tube defects tuaj yeem tshwm sim vim hyperhomocysteineemia.
Dab tsi zoo sib xws ntawm CRP thiab Homocysteine ?
- CRP thiab Homocysteine yog cov cim ntawm kev mob.
- siab ntawm ob hom qhia txog kab mob.
- Tseem, nkawd ob leeg nyob hauv cov ntshav.
- Ob leeg tuaj yeem ntsuas tau ntawm qib kho mob.
- Tsis tas li ntawd, lawv yog cov kws kho mob txhim khu kev qha ntawm qhov mob thiab lwm yam kab mob.
Qhov txawv ntawm CRP thiab Homocysteine yog dab tsi?
CRP yog cov protein thaum homocysteine yog non-proteinogenic amino acid. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm CRP thiab homocysteine . Tsis tas li ntawd, CRP synthesis tshwm sim hauv daim siab thaum homocysteine biosynthesis tshwm sim los ntawm methionine los ntawm txoj kev metabolic. Li no, qhov no kuj yog qhov txawv ntawm CRP thiab homocysteine.
Cov lus qhia hauv qab no ntawm qhov sib txawv ntawm CRP thiab homocysteine muab kev sib piv kom ntxaws ntxiv.
Summary – CRP vs Homocysteine
Cov cim sib txawv qhia txog kev mob tshwm sim hauv peb lub cev. Ntawm cov cim sib txawv, C reactive protein thiab homocysteine yog ob qho tseem ceeb inflammatory markers. CRP yog pentameric protein tam sim no nyob rau hauv cov ntshav plasma nws qib nce vim o. Raws li, lub siab yog cov khoom nruab nrog cev uas tsim cov CRP hauv cov lus teb rau cov cim qhia tawm los ntawm macrophages thiab adipocytes.
Ntawm qhov tod tes, homocysteine yog ib qho uas tsis yog-proteinogenic alpha amino acid, uas yog homologue ntawm amino acid cysteine nrog ib qho ntxiv methylene choj. Yog li ntawd, qhov nce los ntawm qib ib txwm ntawm homocysteine ua rau hyperhomocysteineemia uas ua rau ischemic raug mob. Tsis tas li ntawd, hyperhomocysteineemia ua rau muaj kev pheej hmoo rau kab mob plawv thiab. Yog li, qhov no yog qhov txawv ntawm CRP thiab homocysteine.
