Qhov Tseem Ceeb Qhov txawv - Oncogene vs Tumor Suppressor Gene
Oncogene thiab mutated qog suppressor gene yog ob hom noob uas mob qog noj ntshav muaj. Ib qho oncogene hauv nws cov theem ib txwm raug hu ua proto-oncogene. Cancerous oncogenes tshwm sim los ntawm kev ua kom muaj zog (txog kev cai) ntawm proto-oncogenes thaum qog nqaij hlav qog ua rau mob qog noj ntshav thaum lawv nyob hauv inactivated state. Qhov no yog qhov sib txawv tseem ceeb ntawm oncogene thiab qog suppressor noob uas muaj feem xyuam rau qhov tshwm sim ntawm mob qog noj ntshav.
Cov qog nqaij hlav cancer txhais tau tias yog cov hlwb uas muaj cov txheej txheem sib faib tsis tu ncua uas hloov lawv mus rau hauv cov qog nqaij hlav. Lawv muaj ob hom noob loj uas koom nrog kev hloov pauv ntawm lub cev ib txwm muaj rau hauv daim ntawv mob qog noj ntshav lossis mob qog noj ntshav. Lawv yog oncogene thiab mutated qog suppressor noob. Oncogene thiab qog suppressor noob txawv ntawm ib leeg nyob rau hauv ib tug xov tooj ntawm txoj kev xws li cov qauv ntawm cov qub txeeg qub tes, lub mechanism ntawm kev ua hauj lwm, thiab lwm yam. Kev ua haujlwm ntawm proto-oncogene yog tso cai rau lub cell loj hlob. Tab sis thaum proto-oncogene tau hloov pauv, nws hloov mus rau hauv kev mob qog noj ntshav ua rau oncogene. Tib lub hauv paus ntsiab lus nyob tom qab qog suppressor noob uas lawv ua haujlwm los tswj cov cell faib hauv lawv cov qauv ib txwm, tab sis vim muaj kev hloov pauv hauv cov noob, nws tau hloov mus rau lwm hom noob uas txhawb nqa kev faib tawm ntawm tes..
Dab tsi yog Oncogene?
Ib tug proto-oncogene yog cov noob ib txwm siv rau cov protein tshwj xeeb. Cov protein no feem ntau koom nrog kev faib cov cellular. Txij li thaum cov txheej txheem cellular faib muaj ntau cov kauj ruam, muaj cov protein ntau tseem ceeb heev nyob rau hauv cov ntsiab lus ntawm cov txheej txheem kev tswj. Xav txog cov khoom thiab cov haujlwm ntawm cov protein no coded los ntawm proto-oncogene, nws yog ib qho tseem ceeb ntawm cov protein rau kev pib ntawm tes faib. Lwm yam tshaj li qhov pib ntawm kev faib cell, proto-oncogenes koom nrog kev tswj hwm ntawm apoptosis; programmed cell tuag. Yog li, proto-oncogenes yog cov noob caj noob ces uas koom nrog cov haujlwm tseem ceeb ntawm tes. Tab sis thaum proto-oncogenes hloov pauv, lawv hloov mus rau hauv oncogenes uas muaj cov haujlwm tsis zoo. Yog li, oncogene tuaj yeem txhais tau tias yog cov noob uas muaj peev xwm ua rau mob qog noj ntshav. Thaum cov proto-oncogene ua qhov txawv txav (oncogene) nws tsis teb rau cov cim nres uas tau muab los ntawm cov qog suppressor noob.
Cov lej oncogene rau cov protein sib txawv thiab ua rau muaj cov protein ntau uas yuav txhawb nqa cov cell faib tsis tu ncua. Qhov kev faib tawm ntawm tes tsis muaj kev tswj hwm no ua rau muaj kev loj hlob ntawm qog nqaij hlav. Qhov tseeb tseem ceeb ntawm oncogene yog tias nws tuaj yeem txhawb kev faib tawm ntawm tes tsis muaj zog los ntawm tsuas yog ib qho hloov pauv ntawm nws cov noob.
Daim duab 01: Oncogene
Ib qho oncogene muaj peev xwm txhim kho mus rau hauv cov qog tsis hais txog qhov nres. Cov qog loj hlob sai dua tshwm sim vim muaj ob lub oncogenes lossis ib qho oncogene ntxiv rau ib qho qog nqaij hlav hloov pauv gene.
Tus Kab Mob Ntshav Qab Zib yog dab tsi?
Ib qog nqaij hlav qog ntshav txhais tau tias yog cov noob ib txwm muaj nyob hauv cov hlwb ntawm lub cev. Nws kuj tseem hu ua antioncogene. Cov qog suppressor noob tuaj yeem hloov mus rau hauv cov qog ua rau cov noob yog tias nws hloov pauv. Nyob rau hauv nws cov theem ib txwm, qog-suppressing noob ua hauj lwm nyob rau hauv cov kev cai ntawm lub cell voj voog nyob rau hauv ntau txoj kev xws li qeeb ntawm lub voj voog ntawm tes, cim cov hlwb rau apoptosis, kev sib txuas ntawm lub voj voog ntawm tes rau DNA puas, kho DNA, thiab lwm yam.. Nyob rau hauv cov ntsiab lus ntawm kev ua kom qeeb ntawm cov txheej txheem ntawm tes, cov qog suppressor gene encodes rau cov protein tshwj xeeb uas ua rau muab lub teeb liab 'stop' uas suppresses cell faib thaum tsim nyog.
Nws yog ib qho tseem ceeb uas cov protein uas tsim tawm yuav tsum yog qhov qub kom tsis txhob faib cov cell. Tab sis yog tias muaj kev hloov pauv tshwm sim hauv cov qog qog nqaij hlav, ces cov noob tau hloov mus rau theem txawv txav uas nws raug hu ua qog nqaij hlav ua rau mob qog noj ntshav. Cov noob caj noob ces txawv txav no rau cov protein sib txawv thiab cov protein tshwj xeeb tsis muab lub cim tseem ceeb nres rau cov txheej txheem ntawm tes. Qhov no ua rau qhov kev faib tsis tau ntawm tes uas zoo ib yam li oncogene muaj nuj nqi.
Qhov tseem ceeb ntawm cov qog-tshuaj noob caj noob ces yog tias nws ua rau mob qog noj ntshav hauv nws daim ntawv tsis muaj zog. Tsis tas li ntawd, tsis zoo li oncogene, qog suppressor noob xav tau ob qho kev hloov pauv rau kev loj hlob ntawm qog noj ntshav. Ib lub noob caj noob ces tsis txaus rau qhov no vim tias lwm cov allele ib txwm yuav code rau cov protein kom raug uas tsim nyog los tsim cov teeb liab nres ntawm cov txheej txheem faib.
Dab tsi yog qhov zoo sib xws ntawm Oncogene thiab Tumor Suppressor Gene?
- Ob leeg Oncogene thiab qog Suppressor Gene hauv lawv cov qauv ib txwm yog hom tseem ceeb ntawm cov noob rau ntau lub zog ntawm tes.
- Ob qho tib si Oncogene thiab Tumor Suppressor Gene hauv lawv daim ntawv hloov pauv ua rau mob qog noj ntshav.
Dab tsi yog qhov txawv ntawm Oncogene thiab Tumor Suppressor Gene?
Oncogene vs Tumor Suppressor Gene |
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| Ib qho oncogene txhais tau tias yog kev hloov pauv proto-oncogene uas muaj peev xwm ua rau mob qog noj ntshav. | Ib tug qog suppressor noob txhais tau tias yog ib hom noob uas muaj nyob hauv cov hlwb ntawm lub cev uas tuaj yeem hloov mus rau hauv cov qog ua rau cov noob vim kev hloov pauv. |
| Relation to Cancer | |
| Oncogene ua rau mob qog noj ntshav. | Tumor suppressor gene tiv thaiv cov hlwb ua qog noj ntshav. |
| xeev ntawm caj ces thaum ua rau mob qog noj ntshav | |
| Oncogenes nyob rau hauv daim ntawv nquag thaum ua rau mob qog noj ntshav. | Cov qog nqaij hlav qog ua rau mob qog noj ntshav thaum lawv nyob hauv daim ntawv tsis muaj zog. |
| Kev hloov pauv tshwm sim | |
| Oncogene mutation tshwm sim hauv cov hlwb somatic. | Cov qog suppressor noob mutation tshwm sim hauv cov kab mob thiab cov hlwb somatic. |
| Nyob zoo | |
| Vim qhov kev hloov pauv ntawm oncogene tshwm sim hauv cov hlwb somatic, nws tsis tau txais txiaj ntsig. | Yog cov qog nqaij hlav qog hloov pauv tshwm sim hauv cov kab mob hauv cov kab mob, nws muaj peev xwm ua tau qub. |
Summary – Oncogene vs Tumor Suppressor Gene
Cov qog nqaij hlav cancer qhia txog kev faib cov cell uas tsis tuaj yeem ua rau muaj kev loj hlob ntawm cov qog nqaij hlav. Oncogene thiab mutated qog suppressor noob yog ob hom noob uas ua rau mob qog noj ntshav. Ib qho oncogene yog txhais tau tias yog ib qho kev hloov pauv ntawm proto-oncogene uas muaj peev xwm loj hlob mus rau mob qog noj ntshav. Proto-oncogenes yog cov noob caj noob ces. Kev hloov pauv hauv ib qho ntawm cov alleles ntawm proto-oncogene ua rau kev hloov pauv ntawm proto-oncogene rau hauv oncogene thiab kev loj hlob ntawm mob qog noj ntshav. Lub qog suppressor gene yog txhais tau tias yog cov noob ib txwm muaj nyob hauv cov hlwb ntawm lub cev. Nws tsim cov teeb liab nres uas xav tau los tswj kev faib tawm ntawm tes. Yog li ntawd, qog nqaij hlav suppressor noob tseem hu ua antioncogenes. Tab sis thaum kev hloov pauv tshwm sim hauv ob qho tib si ntawm cov noob, nws tuaj yeem hloov mus rau hauv cov qog ua rau cov noob. Qhov no yog qhov txawv ntawm oncogene thiab qog suppressor gene.
