Qhov Tseem Ceeb Qhov txawv - Huntington's Disease vs Alzheimer's
Huntington tus kab mob yog ib qho ua rau chorea, feem ntau tshwm sim nyob rau hauv nruab nrab xyoo ntawm lub neej thiab tom qab ntawd los ua nyuaj rau kev puas hlwb thiab kev txawj ntse txawv txav. Alzheimer's kab mob yog ib qho mob neurodegenerative ntawm lub hlwb, uas yog tus cwj pwm los ntawm atrophy ntawm lub hlwb cov ntaub so ntswg thiab nws tau raug txheeb xyuas tias yog feem ntau ua rau dementia. Hauv Huntington tus kab mob, muaj qhov cuam tshuam loj ntawm lub cev muaj zog uas tsis pom nyob hauv Alzheimer's kab mob. Qhov no yog qhov sib txawv tseem ceeb ntawm Huntington's disease thiab Alzheimer's.
Huntington's Disease yog dab tsi?
Huntington tus kab mob yog ib qho ua rau chorea feem ntau tshwm sim nyob rau hauv nruab nrab xyoo ntawm lub neej thiab tom qab ntawd los ua nyuaj rau kev puas hlwb thiab kev txawj ntse txawv txav. CAG trinucleotide rov nthuav dav tau raug txheeb xyuas los ua qhov ua rau tus mob no. Ib qho kev sib raug zoo tau raug kwv yees ntawm cov naj npawb rov ua dua thiab lub hnub nyoog pib, nrog ntau dua 60 rov ua dua tshiab hauv cov xwm txheej ntawm cov menyuam yaus. Muaj ib qho kev nyiam rau cov tiam tom ntej muaj qhov pib ntxov thiab muaj kab mob hnyav dua li tiam dhau los.
Daim duab 01: Huntington's Disease
Tam sim no tsis muaj tshuaj kho kab mob. Progressive neurodegeneration ua rau dementia thiab tuag tom qab 10-20 xyoo.
Alzheimer's yog dab tsi?
Tus kab mob Alzheimer yog qhov ua rau muaj kev dementia ntau tshaj.
Kev Kho Mob Ntawm Alzheimer's
Qhov chaw kho mob tseem ceeb ntawm tus mob no yog,
- Kev tsis txaus ntseeg
- nyuaj nrog cov lus
- Apraxia
- Agnosia
- Frontal executive function- impairment hauv kev npaj, npaj, thiab sequencing
- Visuospatial nyuaj
- nyuaj nrog kev taw qhia hauv qhov chaw thiab navigation
- Posterior cortical atrophy
- Tus kheej
- Anosognosia
Txawm hais tias qhov kev tshawb fawb ntau npaum li cas ntawm cov ncauj lus no tseem tsis tuaj yeem nrhiav qhov tseeb ntawm tus kab mob, nws tau nthuav tawm ntau yam txog cov kab mob molecular ntsig txog tus kab mob. Deposition ntawm beta-amyloid nyob rau hauv amyloid plaques thiab tsim ntawm tau-muaj neurofibrillary tangles yog cov yam ntxwv ntawm Alzheimer tus kab mob. Kev tso cov amyloid hauv cov hlab ntsha hauv hlwb tuaj yeem ua rau amyloid angiopathy
Thawj cov txheeb ze muaj ob npaug ntawm kev pheej hmoo siab Alzheimer's dua li cov pej xeem ib txwm muaj. Kev hloov pauv hauv cov noob hauv qab no yog qhov ua rau autosomal tseem ceeb ntawm cov kab mob Alzheimer.
- Amyloid precursor protein
- Presenilin 1 thiab 2
- E4 allele ntawm apolipoprotein E
Daim duab 02: Alzheimer's
Risk Factors
- Advanced age
- Head trauma
- Vascular risk factors
- tsev neeg keeb kwm
- Txiv neej predisposition
Thaum twg muaj qhov tsis txaus ntseeg ntawm kev soj ntsuam ntawm Alzheimer's kab mob, CT scan ntawm lub hlwb raug ua; Qhov no yuav qhia txog kev hloov pauv xws li atrophy nyob rau hauv lub xub ntiag ntawm Alzheimer tus kab mob.
Kev tswj hwm
Tsis muaj kev kho mob rau Alzheimer tus kab mob.
Cholinesterase inhibitors tuaj yeem muab los tswj cov tsos mob neuropsychiatric xws li kev nyuaj siab. Memantatidine kuj tau ua pov thawj tias muaj txiaj ntsig zoo hauv kev tswj cov kab mob thiab cov tsos mob. Cov tshuaj tiv thaiv kev nyuaj siab raug muab tshuaj thaum tsim nyog nrog rau cov tshuaj xws li zolpidem uas tuaj yeem txo qis kev pw tsaug zog.
Dab tsi yog qhov zoo sib xws ntawm Huntington's Disease thiab Alzheimer's
Ob yam mob ua rau dementia
Qhov txawv ntawm Huntington's Disease thiab Alzheimer's yog dab tsi?
Huntington's Disease vs Alzheimer's |
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| Huntington tus kab mob yog ib qho ua rau mob chorea feem ntau tshwm sim hauv nruab nrab xyoo ntawm lub neej thiab tom qab ntawd ua rau muaj kev puas siab puas ntsws thiab kev paub tsis meej | Alzheimer's disease yog ib qho mob neurodegenerative ntawm lub hlwb uas yog tus cwj pwm los ntawm atrophy ntawm lub hlwb cov ntaub so ntswg, thiab nws tau raug txheeb xyuas tias yog feem ntau ua rau dementia. |
| Kev tsis taus | |
| Nyob rau hauv Huntington tus kab mob, muaj feem ntau lub cev tsis muaj zog. | Nyob hauv Alzheimer's disease, kev paub tsis meej yog qhov tseem ceeb dua. |
| Tshuaj kho mob | |
| Tus neeg mob feem ntau muaj chorea nrog rau lwm yam kev paub txawv txav xws li dementia. |
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| Kev tswj hwm | |
| Tam sim no tsis muaj tshuaj kho kab mob. Progressive neurodegeneration ua rau dementia thiab tuag tom qab 10-20 xyoo. |
Tsis muaj kev kho mob rau tus kab mob Alzheimer. Cholinesterase inhibitors tuaj yeem muab los tswj cov tsos mob neuropsychiatric xws li kev nyuaj siab. Memantatidine kuj tau ua pov thawj tias muaj txiaj ntsig zoo los tswj kev kis tus kab mob thiab cov tsos mob. Cov tshuaj tiv thaiv kev nyuaj siab raug muab tshuaj thaum tsim nyog nrog rau cov tshuaj xws li zolpidem uas tuaj yeem txo qis kev pw tsaug zog. |
Summary – Huntington's Disease vs Alzheimer's
Huntington tus kab mob yog ib qho ua rau chorea feem ntau tshwm sim nyob rau hauv nruab nrab xyoo ntawm lub neej thiab tom qab ntawd ua rau muaj teeb meem nrog kev puas hlwb thiab kev txawj ntse txawv txav whereas Alzheimer's kab mob yog ib tug neurodegenerative mob ntawm lub hlwb uas yog yus muaj los ntawm atrophy ntawm lub hlwb cov ntaub so ntswg. Alzheimer's tau raug txheeb xyuas tias feem ntau ua rau dementia. Hauv Huntington's, cov khoom siv lub cev muaj zog feem ntau cuam tshuam, tab sis hauv Alzheimer's, kev paub txog kev ua haujlwm feem ntau cuam tshuam. Qhov no yog qhov sib txawv loj ntawm Huntington's thiab Alzheimer's.
