Qhov Tseem Ceeb Qhov txawv - Parkinson's vs Huntington's Disease
Qhov sib txawv tseem ceeb ntawm Parkinson's thiab Huntington's kab mob yog tias Parkinson tus kab mob (PD) yog ib qho teeb meem nrog rigidity, tremors, slowing ntawm txav, postural instability thiab gait cuam tshuam feem ntau tshwm sim nyob rau hauv lub hnub nyoog laus vim degeneration ntawm substantia nigra ntawm lub midbrain thaum Huntington's disease (HD) yog ib qho teeb meem hauv tsev neeg cov kab mob neurodegenerative feem ntau tshwm sim hauv cov neeg hluas, uas muaj teeb meem kev xav, tsis muaj peev xwm xav (kev paub) thiab txawv txav choreiform (rov ua dua thiab nrawm, jerky, tsis yeem txav).
Parkinson's Disease yog dab tsi?
Parkinson tus kab mob yog ib qho kev puas tsuaj ntawm lub hauv paus paj hlwb feem ntau cuam tshuam rau lub cev muaj zog. Cov tsos mob ntawm tus kab mob Parkinson tshwm sim los ntawm degeneration ntawm dopamine generating hlwb nyob rau hauv lub substantia nigra nyob rau hauv lub midbrain. Qhov ua rau ntawm lub cell tuag no tsis to taub. Thaum ntxov ntawm tus kab mob, cov tsos mob uas pom tseeb tshaj plaws yog co, rigidity, slowness ntawm txav thiab nyuaj rau taug kev thiab gait. Tom qab ntawd, kev xav thiab kev coj tus cwj pwm teeb meem tshwm sim, nrog kev dementia feem ntau tshwm sim nyob rau theem siab ntawm tus kab mob. Kev nyuaj siab yog cov tsos mob ntawm kev puas hlwb feem ntau. Lwm cov tsos mob suav nrog kev hnov lus, teeb meem pw tsaug zog thiab teeb meem txog kev xav.
Parkinson tus kab mob muaj ntau dua rau cov neeg laus, thiab feem ntau tshwm sim tom qab hnub nyoog 50; Thaum nws pom nyob rau hauv cov hluas, nws yog hu ua hluas pib Parkinson tus kab mob. Kev kuaj mob yog los ntawm keeb kwm kho mob thiab kuaj lub cev. Tsis muaj kev kho rau PD, tab sis cov tshuaj noj, kev phais, thiab kev tswj hwm ntau yam tuaj yeem pab daws cov tsos mob tsis zoo. Cov chav kawm tseem ceeb ntawm cov tshuaj muaj txiaj ntsig zoo rau kev kho mob cov tsos mob yog levodopa, dopamine agonists, thiab MAO-B inhibitors. Cov tshuaj no kuj tuaj yeem ua rau muaj kev cuam tshuam tsis zoo. Kev sib sib zog nqus lub hlwb tau sim ua kev kho mob nrog qee qhov ua tiav.
Huntington's Disease yog dab tsi?
tus kab mob Huntington feem ntau tshwm sim hauv ib tus neeg peb caug lossis plaub caug xyoo. Cov tsos mob thiab cov tsos mob thaum ntxov tuaj yeem suav nrog kev nyuaj siab, kev chim siab, kev sib koom tes tsis zoo, kev txav me me, thiab teeb meem kev kawm cov ntaub ntawv tshiab lossis kev txiav txim siab. Ntau tus neeg uas muaj tus kab mob Huntington tsim kev tsis txaus siab, rov ua dua lub suab hu ua chorea. Raws li tus kab mob no, cov tsos mob tshwm sim ntau dua. Cov neeg uas muaj tus kab mob no kuj muaj kev hloov ntawm tus cwj pwm thiab txo qis hauv kev xav. Cov tib neeg raug cuam tshuam feem ntau nyob li ntawm 15 txog 20 xyoo tom qab cov tsos mob thiab cov tsos mob pib.
Tsis muaj kev saib xyuas rau qhov kev tsis sib haum xeeb no, thiab nws tau txiav txim siab ntau yam los ntawm kev hloov pauv hauv HTT noob. Daim ntawv menyuam yaus ntawm qhov teeb meem no kuj muaj. Chorea tuaj yeem tswj tau nrog tshuaj. Txawm li cas los xij, lwm yam kev ua haujlwm siab dua yog qhov nyuaj rau tswj.
Cov kab mob kis los ntawm MR hlwb scan ntawm tus neeg mob HD.
Qhov txawv ntawm Parkinson's thiab Huntington's Disease yog dab tsi?
Ua rau, Cov tsos mob thiab cov tsos mob, kev kho mob thiab kev tswj hwm, Hnub nyoog ntawm qhov pib ntawm Parkinson's thiab Huntington's Disease:
Cause:
Parkinson's Disease: PD yog tshwm sim los ntawm degeneration ntawm cov neurons hauv Substantia nigra ntawm lub midbrain.
Huntington's Disease: HD yog tshwm sim los ntawm kev hloov pauv hauv HTT noob.
Hnub Nyoog Kawg:
Parkinson's Disease: PD feem ntau tshwm sim tom qab hnub nyoog 50.
Huntington's Disease: HD feem ntau tshwm sim hauv peb caug lossis plaub caug.
Symptoms:
Parkinson's Disease: PD ua rau muaj kev tshee, nruj, qeeb ntawm kev txav thiab txav mus los.
Huntington's Disease: HD ua rau muaj kev ua haujlwm siab dua xws li teeb meem hauv kev xav thiab kev xav ua ke nrog tus cwj pwm chorea.
Kev kho mob:
Parkinson's Disease: PD tau kho nrog tshuaj dopamine-hloov tshuaj xws li levodopa, dopamine agonists, thiab lwm yam.
Huntington's Disease: HD tsis muaj kev kho mob thiab kev kho mob tseem ceeb yog txhawb nqa.
Kev ua neej nyob:
Parkinson's Disease: PD tsis muaj kev cuam tshuam rau lub neej expectancy. Txawm li cas los xij, nws txo qhov kev ua neej zoo.
Huntington's Disease: HD cov neeg mob nyob 15-20 xyoo tom qab pom thawj tus tsos mob.
Image Courtesy: Blausen.com cov neeg ua haujlwm. "Blausen gallery 2014". Wikiversity Journal of Medicine. DOI: 10.15347/wm/2014.010. ISSN 20018762. - Tus kheej ua haujlwm. (CC BY 3.0) ntawm Wikimedia Commons "Huntington" los ntawm Frank Gaillard - Tus kheej ua haujlwm. (CC BY-SA 3.0) via Commons
