Qhov sib txawv tseem ceeb ntawm retinoic acid receptor alpha beta thiab gamma yog tias retinoic acid receptor alpha yog coded los ntawm cov noob RARA thaum retinoic acid receptor beta yog coded los ntawm cov noob RARB, thiab retinoic acid receptor gamma yog coded los ntawm cov noob. RARG.
Retinoic acid receptors yog nuclear receptors. Lawv kuj ua raws li cov kev hloov pauv lossis cov activators. Muaj peb yam sub-hom retinoic acid receptors li retinoic acid receptor alpha, retinoic acid receptor beta thiab retinoic acid receptor gamma. Lawv khi nrog tag nrho-trans retinoic acid thiab 9-cis retinoic acid thiab tau qhib. Retinoic acid yog ib qho kev taw qhia molecule thiab lub active daim ntawv ntawm vitamin A. Nws yog ib qho tseem ceeb rau cov txheej txheem kev loj hlob ntawm lub cev nyob rau hauv vertebrates (organogenesis). Retinoic acid receptors kho cov teebmeem ntawm retinoic acid los ntawm kev khi nrog retinoic acid thiab pab hauv txoj kev taw qhia.
Retinoic Acid Receptor Alpha yog dab tsi?
Retinoic acid receptor alpha yog ib qho ntawm peb lub subtypes ntawm retinoic acid receptors. Nws yog coded los ntawm cov noob RARA. Muaj ob lub isoforms ntawm no receptor protein uas txawv ntawm lawv cov N davhlau ya nyob twg AF-1 domain. Lawv yog RARα1 thiab RARα2.
Daim duab 01: Retinoic Acid Receptor Alpha
RARα yog ib qho receptor nuclear nyob hauv lub nucleus. Nws kuj yog ib qho kev hloov pauv. RARα koom nrog hauv kev tswj hwm kev sib txawv ntawm myeloid. Retinoic acid receptors qhia zoo sib xws. Tab sis lawv kinetics ntawm kev khi yog txawv. RARα tshem tawm 9-cis retinoic acid rau-fold ntau dua RARβ. Tau ntsib 406 thiab Leu 410 hauv RARα tseem ceeb heev thaum khi nrog 9-cis retinoic acid.
Retinoic Acid Receptor Beta yog dab tsi?
Retinoic acid receptor beta yog lwm yam subtype ntawm retinoic acid receptors. Qhov no receptor protein yog coded los ntawm cov noob RARB. Feem ntau, RARs yog cov qog nqaij hlav. Methylation ntawm RARB noob tau pom tias muaj feem cuam tshuam nrog kev mob qog nqaij hlav.
Daim duab 02: Retinoic Acid Receptor Beta
Cov xwm txheej methylation ntawm RARB gene txhawb nqa hauv tib neeg cov kab mob qog noj ntshav yog pov thawj rau qhov no. Hauv qhov sib piv, demethylation ntawm cov noob no feem ntau inhibits cell loj hlob. Ntxiv mus, RARβ feem ntau qhia tsis zoo hauv cov hlwb myeloid.
Retinoic Acid Receptor Gamma yog dab tsi?
Retinoic acid receptor gamma yog ib qho subtype ntawm retinoic acid receptors. Nws kuj yog ib qho tshuaj tiv thaiv kab mob nuclear. RARγ yog coded los ntawm cov noob RARG. Embryonal Carcinoma thiab Exfoliative Ichthyosis yog ob yam kab mob cuam tshuam nrog RARG noob.
Daim duab 03: Retinoic Acid Receptor Gamma
Qhov kev qhia ntawm RARG noob tau pom tau yooj yim hauv cov hlwb myeloid. Ntxiv mus, tib neeg daim tawv nqaij feem ntau qhia RARγ piv rau lwm yam ob hom. Qhov tseem ceeb tshaj plaws, RARγ nyiam khi nrog tag nrho-trans retinoic acid raws li nws cov ligand tshaj 9-cis retinoic acid.
Similarities Ntawm Retinoic Acid Receptor Alpha Beta thiab Gamma
- Retinoic acid receptors alpha, beta thiab gamma yog peb hom subtypes pom nyob rau hauv vertebrate genome.
- Lawv yog nuclear receptors.
- Yog li ntawd, lawv nyob hauv lub hauv paus tseem ceeb.
- Lawv hu ua ligand-activated transcription factor.
- Lawv ua haujlwm raws li kev hloov pauv ib zaug thaum lawv pib ua haujlwm ntawm kev khi ntawm ligand.
- Ntxiv mus, lawv qhia zoo sib xws los khi nrog ligand.
- Retinoic acid tuaj yeem qhib tau tag nrho peb hom receptor.
- Thaum lawv qhib, lawv tswj kev qhia ntawm RA lub hom phiaj noob.
- Lawv muaj peev xwm tsim cov heterodimers ua haujlwm nrog retinoid X receptors.
- Cov receptors no kuj suav tias yog cov qog nqaij hlav.
- Lawv txhua tus muaj tib lub tsev tsim qauv ntawm DNA-binding domain thiab co-activator binding domain.
Qhov txawv ntawm Retinoic Acid Receptor Alpha Beta thiab Gamma
Retinoic acid receptor alpha yog subtype ntawm nuclear receptor coded los ntawm cov noob RARA, thaum retinoic acid receptor beta yog thib ob subtype ntawm nuclear receptor coded los ntawm cov noob RARB thiab retinoic acid receptor gamma yog thib peb subtype ntawm nuclear receptor. coded los ntawm gene RARG. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm retinoic acid receptor alpha beta thiab gamma.
Cov hauv qab no infographic teev qhov sib txawv ntawm retinoic acid receptor alpha beta thiab gamma hauv daim ntawv tabular rau ib sab ntawm kev sib piv.
Summary – Retinoic Acid Receptor Alpha vs Beta vs Gamma
Retinoic acid receptors thiab retinoid X receptors yog ob tsev neeg ntawm cov receptors nuclear uas kho cov teebmeem retinoic acid thiab ua haujlwm. Retinoic acid receptors yog peb hom alpha, beta thiab gamma. Lawv yog cov isoforms. Peb cov receptors no, α, β, thiab γ yog coded los ntawm peb qhov sib txawv nuclear receptor genes. Lawv qhia ib tug zoo xws li architecture tab sis txawv kinetics nyob rau hauv khi nrog lub ligand. Yog li, qhov no yog cov ntsiab lus ntawm qhov sib txawv ntawm retinoic acid receptor alpha beta thiab gamma.
