Qhov Tseem Ceeb Qhov txawv - Myasthenic Crisis vs Cholinergic Crisis
Myasthenic ntsoog tuaj yeem piav qhia raws li qhov teeb meem ntawm myasthenia gravis qhov twg muaj qhov tshwm sim sai sai ntawm cov xwm txheej kho mob. Cholinergic ntsoog yog vim lub tsub zuj zuj ntawm acetylcholine nyob rau hauv lub neuromuscular hlws ris. Inactivation ntawm acetylcholinesterase enzyme uas cleaves Ach nyob rau hauv lub neuromuscular hlws ris yog vim li cas rau tus mob no feem ntau ntawm lub sij hawm. Kev tswj hwm ntawm edrophonium ua rau qhov hnyav ntawm cov tsos mob ntawm cholinergic ntsoog, tab sis nws alleviates cov tsos mob ntawm myasthenic ntsoog. Qhov no yog qhov sib txawv tseem ceeb ntawm ob qhov kev tsis sib haum xeeb.
Myasthenia Gravis yog dab tsi?
Myasthenia gravis yog ib qho kab mob autoimmune uas tshwm sim los ntawm kev tsim cov tshuaj tiv thaiv kab mob uas thaiv kev sib kis ntawm impulses hla cov kab mob neuromuscular. Cov tshuaj tiv thaiv no khi rau postsynaptic Ach receptors yog li tiv thaiv kev khi ntawm Ach hauv synaptic cleft rau cov receptors. Cov poj niam muaj tsib zaug cuam tshuam los ntawm tus mob no ntau dua li txiv neej. Muaj kev koom tes tseem ceeb nrog rau lwm yam kab mob autoimmune xws li mob caj dab rheumatoid, SLE, thiab autoimmune thyroiditis. Concurrent thymic hyperplasia tau pom.
Tshuaj Kho Mob
- Muaj qhov tsis muaj zog ntawm cov leeg nqaij limb, cov leeg sab nraud, thiab cov leeg pob txha
- muaj zog thiab hloov pauv ntawm cov leeg tsis muaj zog
- Tsis mob leeg
- Lub plawv tsis cuam tshuam, tab sis cov leeg ua pa tuaj yeem cuam tshuam
- Reflexes kuj fatigable
- Diplopia, ptosis, thiab dysphagia
Kev tshawb nrhiav
- Anti ACh receptor antibodies hauv cov ntshav
- Tensilon kuaj qhov twg koob tshuaj edrophonium raug tswj hwm uas ua rau muaj kev txhim kho ib ntus ntawm cov tsos mob uas kav ntev li 5 feeb
- Kev Tshawb Fawb
- ESR and CRP
Kev tswj hwm
- Kev tswj hwm ntawm anticholinesterases xws li pyridostigmine
- Immunosuppressants xws li corticosteroids tuaj yeem muab rau cov neeg mob uas tsis teb rau anticholinesterases
- YThymectomy
- Plasmapheresis
- YIntravenous immunoglobulins
Muaj ob qhov teebmeem kev kho mob uas tuaj yeem tshwm sim hauv tus neeg mob muaj myasthenia gravis raws li qhov teebmeem myasthenic thiab cholinergic ntsoog.
Dab tsi yog Myasthenic Crisis?
Myasthenic ntsoog tuaj yeem piav qhia raws li qhov teeb meem ntawm myasthenia gravis qhov twg muaj qhov tshwm sim sai sai ntawm cov xwm txheej kho mob. Yuav tsum tau ceev intubation los tiv thaiv qhov tshwm sim ntawm kev tuag tom qab ua pa tsis ua haujlwm.
Tshuaj Kho Mob
- Dyspnea
- Dysphagia
- Dysphonia
- Qee zaum hnoos
- Cov tsos mob txhim kho nrog edrophonium
Daim duab 01: Ib Nrab Neuromuscular Junction
Kev kho mob
- Kev them nyiaj yug Ventilator
- Siv cov tshuaj anticholinergic, tshuaj tiv thaiv kab mob, thiab immunoglobulins
- Kev tswj cov kua dej hauv cov hlab ntsha kom tiv thaiv hypovolemia
Cholinergic Crisis yog dab tsi?
Cholinergic ntsoog yog vim muaj cov acetylcholine nyob rau hauv lub neuromuscular hlws ris. Inactivation ntawm acetylcholinesterase enzyme uas cleaves Ach nyob rau hauv lub neuromuscular hlws ris yog vim li cas rau tus mob no feem ntau ntawm lub sij hawm.
Nyob rau hauv myasthenia gravis, muaj qhov nce hauv cholinergic kev ua ub no vim tsis muaj inhibition los ntawm dopamine. Txhawm rau tiv thaiv qhov no, cov tshuaj nrog cov tshuaj anticholinesterase tau sau tseg. Kev noj tshuaj ntau dhau lossis sib sau ntawm cov tshuaj no tuaj yeem cuam tshuam qhov kev ua ntawm anticholinesterase enzyme yog li ua rau muaj teeb meem cholinergic.
Cov yam ntxwv ntawm cholinergic Crisis
- Salivation
- Lacrimation
- tso zis
- Zoo plab
- Pupillary constriction
- Kev ua tsis taus pa ntawm cov leeg ua pa tuaj yeem ua rau ua pa tsis ua haujlwm
- mob plab
- Ntaus thiab ntuav
Kev kuaj mob ntawm cholinergic ntsoog yog los ntawm kev tswj hwm ntawm edrophonium. Thaum muaj kev kub ntxhov, edrophonium ua rau cov tsos mob hnyav zuj zus.
Daim duab 02: Tus neeg mob raug kev txom nyem los ntawm Cholinergic Crisis
Kev kho mob
- Lub tshuab ua pa yog muab los tiv thaiv kev ua pa tsis ua haujlwm
- Atropine kuj tuaj yeem tswj hwm los tiv thaiv cov haujlwm ACh ntau dhau.
Dab tsi zoo sib xws ntawm Myasthenic Crisis thiab Cholinergic Crisis?
- Ob leeg yog qhov ua rau muaj kev phom sij rau lub neej uas suav tias yog xwm txheej xwm txheej ceev
- Lub tshuab ua pa yuav tsum tau pab cawm tus neeg mob txoj sia ntawm ob qho kab mob.
Qhov txawv ntawm Myasthenic Crisis thiab Cholinergic Crisis yog dab tsi?
Myasthenic Crisis vs Cholinergic Crisis |
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| Myasthenic ntsoog tuaj yeem piav qhia raws li qhov teeb meem ntawm myasthenia gravis qhov twg muaj qhov tshwm sim sai sai ntawm cov xwm txheej kho mob. | Cholinergic ntsoog yog vim muaj cov acetylcholine nyob rau hauv lub neuromuscular hlws ris. Inactivation ntawm acetylcholinesterase enzyme uas cleaves Ach nyob rau hauv lub neuromuscular hlws ris yog vim li cas rau tus mob no feem ntau ntawm lub sij hawm. |
| Cov tsos mob | |
| Cov tsos mob zoo dua nrog edrophonium. | Cov tsos mob txhim kho nrog edrophonium |
| Tshuaj kho mob | |
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kho mob nta ntawm myasthenic ntsoog · Dyspnea · Dysphagia · Dysphonia · Qee zaum hnoos · Cov tsos mob txhim kho nrog edrophonium |
Cov tsos mob thiab cov cim qhia ntawm cholinergic ntsoog · Salivation · Lacrimation · tso zis · Mob plab · Pupillary constriction · Kev ua tsis taus ntawm cov leeg ua pa tuaj yeem ua rau ua pa tsis ua haujlwm · mob plab · xeev siab thiab ntuav · Cov kuab tshuaj ntau dhau |
Summary – Myasthenic Crisis vs Cholinergic Crisis
Myasthenic ntsoog tuaj yeem piav qhia raws li qhov teeb meem ntawm myasthenia gravis qhov twg muaj qhov tshwm sim sai sai ntawm cov xwm txheej kho mob. Cholinergic ntsoog yog vim lub tsub zuj zuj ntawm acetylcholine nyob rau hauv lub neuromuscular hlws ris. Inactivation ntawm acetylcholinesterase enzyme uas cleaves Ach nyob rau hauv lub neuromuscular hlws ris yog vim li cas rau cov mob no feem ntau ntawm lub sij hawm. Edrophonium ua rau cov tsos mob ntawm cholinergic ntsoog tab sis ua rau nce mus rau ib ntus nyem ntawm cov tsos mob ntawm myasthenia gravis. Qhov no yog qhov txawv ntawm myasthenic thiab cholinergic crises.
Download the PDF of Myasthenic Crisis vs Cholinergic Crisis
Koj tuaj yeem rub tawm PDF version ntawm kab lus no thiab siv nws rau offline hom phiaj raws li daim ntawv ceeb toom. Thov rub tawm PDF version ntawm no: Qhov txawv ntawm Myasthenic Crisis thiab Cholinergic Crisis
