Qhov Tseem Ceeb Qhov txawv - MS vs Parkinson's
MS thiab Parkinson tus kab mob yog ob yam kab mob cuam tshuam rau lub hauv paus paj hlwb. Multiple Sclerosis (MS) yog ib qho mob autoimmune, T-cell mediated inflammatory kab mob cuam tshuam rau hauv nruab nrab paj hlwb. Ntawm qhov tod tes, Parkinson tus kab mob yog ib qho kev tsis sib haum xeeb uas tshwm sim los ntawm kev poob qis hauv qib dopamine ntawm lub hlwb. Txawm hais tias MS yog ib qho kab mob autoimmune, tsis muaj kev tiv thaiv kab mob hauv lub pathogenesis ntawm Parkinson tus kab mob. Qhov no yog qhov txawv ntawm MS thiab Parkinson's.
MS yog dab tsi?
Ntau Sclerosis yog ib qho mob autoimmune, T-cell mediated inflammatory kab mob cuam tshuam rau hauv nruab nrab paj hlwb. Ntau qhov chaw ntawm demyelination muaj nyob rau hauv lub hlwb thiab tus txha caj qaum. Qhov tshwm sim ntawm MS yog siab dua ntawm cov poj niam. MS feem ntau tshwm sim ntawm 20 thiab 40 xyoo. Qhov tshwm sim ntawm tus kab mob sib txawv raws li thaj chaw thaj chaw thiab haiv neeg keeb kwm yav dhau los. Peb qhov kev nthuav qhia ntau tshaj plaws ntawm MS yog;
- kho qhov muag neuropathy
- brain qia demyelination, thiab
Cov neeg mob MS raug rau lwm yam kab mob autoimmune. Ob qho tib si noob caj noob ces thiab ib puag ncig cuam tshuam rau lub pathogenesis ntawm tus kab mob.
Pathogenesis
T cell-mediated inflammatory txheej txheem tshwm sim feem ntau nyob rau hauv cov teeb meem dawb ntawm lub hlwb thiab qaum qaum, ua plaques ntawm demyelination. 2-10 hli loj plaques feem ntau pom muaj nyob rau hauv cov hlab ntsha optic, periventricular cheeb tsam, corpus callosum, hlwb qia thiab nws cov cerebellar kev sib txuas thiab lub ncauj tsev menyuam qaum.
Nyob rau hauv MS, peripheral myelinated qab haus huv tsis cuam tshuam ncaj qha. Nyob rau hauv daim ntawv loj ntawm tus kab mob, kev puas tsuaj mus tas li axonal tshwm sim, ua rau muaj kev tsis taus.
Hom Ntau Yam Sclerosis
- Raws-remitting MS
- Secondary progressive MS
- Primary progressive MS
- Relapsing-progressive MS
Cov cim qhia thiab cov tsos mob
- Mob qhov muag txav
- me me fogging ntawm lub hauv paus tsis pom kev / xim desaturation / ntom ntom nti
- Txo kev vibration sensation thiab proprioception hauv ko taw
- Clumsy tes or limb
- Kev tsis ruaj khov hauv kev taug kev
- tso zis ceev thiab zaus
- Neuropathic mob
- Nyob
- Spasticity
- Kev nyuaj siab
- Kev sib deev tsis zoo
- Kub rhiab
Nyob rau hauv MS lig, cov tsos mob hnyav heev, nrog optic atrophy, nystagmus, spastic tetraparesis, ataxia, lub paj hlwb cov tsos mob, pseudobulbar palsy, urinary incontinence thiab kev paub tsis meej tuaj yeem pom.
Daim duab 01: MS
Diagnosis
Kev kuaj mob MS tuaj yeem ua tau yog tias tus neeg mob tau muaj 2 lossis ntau qhov kev tawm tsam cuam tshuam rau ntau qhov chaw ntawm CNS. MRI yog qhov kev tshawb nrhiav tus qauv siv hauv kev pom zoo ntawm kev kuaj mob. Kev kuaj CT thiab CSF tuaj yeem ua tiav los muab cov pov thawj txhawb ntxiv rau kev kuaj mob yog tias tsim nyog.
Kev tswj hwm
Tsis muaj qhov kho tau meej rau MS. Tab sis ob peb cov tshuaj immunomodulatory tau qhia los hloov kho cov txheej txheem ntawm inflammatory relapsing-remitting theem ntawm MS. Cov no yog hu ua Disease Modifying Drugs (DMDs). Beta-interferon thiab glatiramer acetate yog cov piv txwv ntawm cov tshuaj no. Sib nrug los ntawm kev kho tshuaj, kev ntsuas dav dav xws li kev kho lub cev, kev txhawb nqa tus neeg mob nrog kev pab los ntawm pab pawg neeg sib koom tes thiab kev ua haujlwm kho mob tuaj yeem txhim kho kev ua neej nyob ntawm tus neeg mob.
Kev Tshawb Fawb
Qhov kev cia siab ntawm ntau tus kab mob sclerosis txawv ntawm qhov tsis tuaj yeem kwv yees. Qhov siab MR lesion load ntawm qhov kev nthuav qhia thawj zaug, tus nqi rov qab siab dua, txiv neej poj niam txiv neej thiab kev nthuav qhia lig yog feem ntau cuam tshuam nrog qhov tsis zoo. Qee tus neeg mob tseem nyob hauv lub neej ib txwm tsis muaj kev xiam oob khab thaum qee tus tuaj yeem ua rau mob hnyav.
Parkinson yog dab tsi?
Parkinson tus kab mob yog ib qho kev tsis sib haum xeeb uas tshwm sim los ntawm kev poob qis hauv qib dopamine ntawm lub hlwb. Qhov ua rau ntawm tus mob no tseem muaj teeb meem. Qhov kev pheej hmoo ntawm tus kab mob Parkinson nce ntxiv nrog rau cov hnub nyoog siab heev. Tseem tsis tau txheeb pom qhov qub txeeg qub teg ntawm tsev neeg.
Pathology
Cov tsos ntawm Lewy lub cev thiab poob ntawm dopaminergic neurons nyob rau hauv pars compacta ntawm substantia nigra cheeb tsam ntawm midbrain yog cov kev hloov morphological pom nyob rau hauv tus kab mob Parkinson.
Tshuaj Kho Mob
- Slow txav (bradykinesia/akinesia)
- Ntxhais tremor
- Cov yeeb nkab rigidity ntawm cov ceg tawv uas tau txheeb xyuas thaum kuaj mob
- Kev hais lus ntsiag to, tsis paub meej thiab tiaj tus
- Nyob rau theem kawg ntawm tus kab mob tus neeg mob tuaj yeem txhim kho kev paub tsis meej thiab
Daim duab 02: Parkinson's Disease
Diagnosis
Tsis muaj chaw kuaj xyuas kom paub tseeb tias tus kab mob Parkinson. Yog li, kev kuaj mob tsuas yog ua raws li cov tsos mob thiab cov tsos mob pom tau thaum lub sijhawm kuaj mob. MRI cov duab zoo li qub feem ntau ntawm lub sijhawm.
Kev kho mob
Tus neeg mob thiab tsev neeg yuav tsum tau kawm txog tus mob. Cov tsos mob ntawm lub cev muaj zog tuaj yeem txo tau los ntawm kev siv tshuaj xws li dopamine receptor agonists thiab levodopa uas rov ua haujlwm dopamine ntawm lub hlwb. Kev pw tsaug zog thiab kev puas siab puas ntsws yuav tsum tau tswj kom tsim nyog.
Dopamine antagonists xws li neuroleptics tuaj yeem ua rau Parkinson tus kab mob zoo li cov tsos mob nyob rau hauv rooj plaub uas lawv raug hu ua Parkinsonism.
Qhov Zoo sib xws ntawm MS thiab Parkinson yog dab tsi?
Ob kab mob cuam tshuam rau hauv nruab nrab paj hlwb
Qhov txawv ntawm MS thiab Parkinson yog dab tsi?
MS vs Parkinson's |
|
| Ntau Sclerosis yog ib qho mob autoimmune, T-cell mediated inflammatory kab mob cuam tshuam rau hauv nruab nrab paj hlwb. | Parkinson tus kab mob yog ib qho kev tsis sib haum xeeb uas tshwm sim los ntawm kev poob qis hauv qib dopamine ntawm lub hlwb. |
| Demyelination ntawm cov hlab ntsha hauv lub hlwb thiab qaum qaum yog lub hauv paus pathological ntawm tus kab mob. | Parkinson tus kab mob yog vim qhov poob ntawm dopamine theem ntawm lub hlwb. |
| Tshuaj kho mob | |
|
Cov cim qhia thiab cov tsos mob ntawm MS yog,
Nyob rau hauv MS lig, cov tsos mob hnyav heev ntawm optic atrophy, nystagmus, spastic tetraparesis, ataxia, paj hlwb cov tsos mob, pseudobulbar palsy, urinary incontinence thiab kev paub tsis meej tuaj yeem pom. |
Kev kho mob ntawm tus kab mob Parkinson yog,
Nyob rau theem kawg ntawm tus kab mob, tus neeg mob tuaj yeem tsim kev puas hlwb |
| Diagnosis | |
| MRI yog qhov kev tshawb nrhiav tus qauv siv hauv kev kuaj mob MS. Ntxiv rau qhov CT kuj tseem siv tau nyob ntawm cov chaw muaj. | Tsis muaj chaw kuaj xyuas kom paub tseeb tias tus kab mob Parkinson. Yog li kev kuaj mob tsuas yog ua raws li cov cim qhia thiab cov tsos mob pom tau thaum lub sijhawm kuaj mob. MRI cov duab zoo li qub feem ntau ntawm lub sijhawm. |
| Cov tshuaj kho mob xws li beta-interferon thiab glatiramer yog siv rau hauv kev tswj hwm ntawm MS. | Cov tsos mob ntawm lub cev tau kho nrog levodopa thiab dopamine agonists. |
| Ntxhais muaj caj ces | |
| Yuav muaj genetic predisposition. | Tsis muaj pov thawj los qhia txog kev tshuaj ntsuam genetic predisposition. |
Summary – MS vs Parkinson's
Multiple Sclerosis yog ib qho mob autoimmune, T-cell mediated inflammatory kab mob cuam tshuam rau Central Nervous System. Parkinson tus kab mob yog ib qho kev tsis sib haum xeeb uas tshwm sim los ntawm kev poob qis hauv qib dopamine ntawm lub hlwb. Ntau yam sclerosis, raws li tau hais hauv nws cov lus txhais, yog kab mob autoimmune tab sis Parkinson tus kab mob tsis yog kab mob autoimmune. Qhov no yog qhov sib txawv loj ntawm MS thiab Parkinson's.
Download PDF Version of MS vs Parkinson's
Koj tuaj yeem rub tawm PDF version ntawm kab lus no thiab siv nws rau offline hom phiaj raws li cov ntawv sau tseg. Thov download PDF version ntawm no Qhov txawv Ntawm MS thiab Parkinson
