Key Difference – NADH vs FADH2
Ib coenzyme yog cov organic uas tsis yog-protein molecule uas yog qhov me me thiab muaj peev xwm nqa cov tshuaj lom neeg ntawm cov enzymes thiab ua raws li cov khoom siv hluav taws xob. NADH (Nicotinamide Adenine Dinucleotide) thiab FADH2 (Flavin Adenine Dinucleotide) yog ob lub ntsiab coenzymes siv hauv yuav luag txhua txoj hauv kev biochemical. Lawv ua raws li cov khoom siv hluav taws xob thiab koom nrog oxidation-txo cov tshuaj tiv thaiv ntawm cov tshuaj tiv thaiv intermediates. NADH yog ib tug derivative ntawm Vitamin B3 (Niacin / Nicotinamide) thaum FADH2 yog ib tug derivative ntawm Vitamin B2 (Riboflavin). Qhov no yog qhov sib txawv tseem ceeb ntawm NADH thiab FADH2.
NADH yog dab tsi?
NADH yog tsim los ntawm Vitamin B3 (Niacin) thiab yog coenzyme tsim los ntawm ribosylnicotinamide 5′-diphosphate ua ke rau adenosine 5′-phosphate. Nws ua haujlwm raws li tus neeg nqa khoom hluav taws xob hauv ntau qhov kev cuam tshuam los ntawm kev hloov mus rau nws daim ntawv oxidized (NAD +) thiab daim ntawv txo (NADH). Qhov txo NADH ua raws li tus neeg pub khoom siv hluav taws xob thiab oxidize rau NAD+ thaum txo lwm cov tshuaj koom nrog hauv cov tshuaj tiv thaiv. Lub luag haujlwm ntawm NADH no koom nrog cov txheej txheem ntawm glycolysis, TCA lub voj voog thiab hauv cov saw hlau thauj hluav taws xob uas NADH yog ib qho ntawm cov khoom siv hluav taws xob.
Daim duab 01: Cov qauv ntawm NADH thiab NAD +
Lub ntsiab lus melting ntawm NADH yog 140.0 - 142.0 ° C thiab nws tuaj yeem ua ke hauv lub cev thiab tsis yog cov khoom noj tseem ceeb. Tab sis qhov tsis txaus ntawm qhov tseem ceeb ntawm cov vitamin Niacin tuaj yeem ua rau txo qis ntawm NADH hauv lub cev. NADH yog tsim nyob rau hauv cytosol thiab nyob rau hauv mitochondria. Lub mitochondrial membrane yog impermeable rau NADH, thiab qhov teeb meem no txawv ntawm cytoplasmic thiab mitochondrial NADH khw.
Hauv kev lag luam kev lag luam, NADH tau tswj hwm qhov ncauj txhawm rau tiv thaiv kev qaug zog nrog rau thaum lub zog tsis muaj zog thiab cov kab mob metabolic
FADH2 yog dab tsi?
FADH2 yog tsim los ntawm cov dej-soluble vitamin B2, uas tseem hu ua Riboflavin. FADH2 yog qhov txo qis ntawm flavin adenine dinucleotide (FAD).
FAD yog tsim los ntawm riboflavin thiab ob lub molecules ntawm ATP. Riboflavin yog phosphorylated los ntawm ATP los tsim riboflavin 5'-phosphate (tseem hu ua flavin mononucleotide, FMN). FAD yog tom qab ntawd tsim los ntawm FMN los ntawm kev hloov pauv ntawm AMP molecule los ntawm ATP.
Daim duab 02: Cov qauv ntawm FAD thiab FADH
FADH koom nrog hauv ob qho tib si carbohydrate metabolism thiab fatty acid metabolism. Hauv cov metabolism hauv carbohydrate, FADH koom nrog hauv kev sau cov hluav taws xob hluav taws xob uas muaj roj nplua nuj nyob hauv TCA lub voj voog. FADH yog tsim nyob rau hauv txhua puag ncig ntawm fatty acid oxidation, thiab cov fatty acyl saw yog luv luv los ntawm ob cov pa roj carbon atoms los ntawm cov tshuaj tiv thaiv rau yield Acetyl Co A. FADH ua raws li ib tug electron pub nyob rau hauv lub electron thauj.
Dab tsi yog qhov zoo sib xws ntawm NADH thiab FADH2?
- NADH thiab FADH2 yog coenzymes
- Ob leeg ua raws li cov khoom siv hluav taws xob.
- Ob leeg yog nonprotein organic molecules.
- Ob leeg yog muab los ntawm cov vitamins.
- Ob leeg yog dej soluble.
- Ob leeg tuaj yeem muaj nyob hauv daim ntawv txo lossis oxidized daim ntawv.
- Ob leeg koom nrog oxidation thiab txo cov tshuaj tiv thaiv thiab pab hloov cov electrons ntawm ib lub substrate mus rau lwm qhov.
- Ob lub coenzymes tuaj yeem ua rau hauv lub cev.
- Ob lub molecules koom nrog hauv txoj hauv kev metabolic uas suav nrog carbohydrate, fatty acid, amino acid thiab nucleotide metabolism.
Qhov txawv ntawm NADH thiab FADH2 yog dab tsi?
NADH vs FADH2 |
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| NADH yog coenzyme tau los ntawm vitamin B3 lossis niacin. | FADH2 yog coenzyme tau los ntawm Vitamin B2 lossis riboflavin. |
| ATP Tsim tawm | |
| NADH muab 3 ATP. | NADH muab 2 ATP. |
| Daim ntawv thov kev lag luam | |
| NADH yog siv los ua ib qho ntxiv raws li lub zog tsis muaj zog. | No tsis muaj daim ntawv thov kev lag luam. |
Summary – NADH vs FADH2
Lub luag haujlwm ntawm NADH thiab FADH2 yog pub cov khoom siv hluav taws xob rau cov saw hlau thauj hluav taws xob thiab ua raws li cov khoom siv hluav taws xob, uas nqa cov hluav taws xob tso tawm los ntawm cov txheej txheem metabolic sib txawv mus rau cov txheej txheem kawg ntawm kev tsim hluav taws xob, piv txwv li, cov khoom siv hluav taws xob thauj khoom.. Lawv ob leeg pub cov khoom siv hluav taws xob los ntawm kev muab hydrogen molecule rau oxygen molecule los tsim cov dej thaum lub sij hawm thauj electron. Yog li ob qho tib si NADH thiab FADH2 yog qhov tseem ceeb hauv txhua qhov txheej txheem metabolic. Qhov txawv ntawm NADH thiab FADH2 yog tias NADH yog coenzyme tau los ntawm vitamin B3 lossis niacin whereas FADH2 yog coenzyme tau los ntawm Vitamin B2 lossis riboflavin.
Download PDF Version of NADH vs FADH2
Koj tuaj yeem rub tawm PDF version ntawm kab lus no thiab siv nws rau offline hom phiaj raws li daim ntawv ceeb toom. Thov download PDF version ntawm no Qhov txawv Ntawm NADH thiab FADH2
