Qhov Tseem Ceeb - IgM vs IgG
Immunoglobulin M (IgM) thiab Immunoglobulin G (IgG) yog cov tshuaj tiv thaiv lossis immunoglobulin (Ig) cov protein uas tsim los ntawm lub cev tiv thaiv kab mob los tawm tsam cov kab mob thiab rhuav tshem cov antigens. IgM yog ib qho pentameric molecule uas tshwm sim nyob rau theem pib ntawm kev kis kab mob thiab nws muaj kaum qhov chaw sib txuas antigen. IgG yog monomeric molecule uas tshwm sim tom qab kis kab mob thiab muaj ob qhov chaw sib txuas antigen. Qhov no yog qhov sib txawv tseem ceeb ntawm IgM thiab IgG. Cov ntaub ntawv hauv qab no hais txog IgM thiab IgG yuav pab koj nkag siab txog cov qauv thiab kev ua haujlwm sib txawv ntawm IgM thiab IgG.
Immunoglobulin (Ig) yog dab tsi?
Immunoglobulin (Ig), tseem hu ua cov tshuaj tiv thaiv kab mob, yog ib hom protein uas tsim los ntawm cov qe ntshav dawb ntawm lub cev tiv thaiv kab mob los tiv thaiv kab mob los ntawm cov kab mob, kab mob, fungi, protozoan, toxin, thiab lwm yam. Ig yog Y-shaped, loj glycoprotein molecule uas muaj plaub polypeptides hu ua hnyav thiab lub teeb chains raws li qhia nyob rau hauv daim duab 01. Muaj ob lub cheeb tsam loj ntawm cov saw hlau polypeptide: sib txawv thiab tsis tu ncua. Amino acid sequences nyob rau hauv cov cheeb tsam sib txawv ntawm cov polypeptides sib txawv heev ntawm cov immunoglobulin isotypes. Muaj tsib hom isotypes ntawm immunoglobulins: IgA, IgD, IgE, IgG thiab IgM. Isotypes yog categorized raws li lawv cov qauv sib txawv. Lawv muaj cov haujlwm sib txawv thiab cov lus teb antigen.
Figure_1: Plaub-chain qauv ntawm cov tshuaj tiv thaiv caj ces
IgM yog dab tsi?
IgM yog thawj hom tshuaj tiv thaiv hauv lub cev ua thawj cov lus teb rau tus kab mob los ntawm lub cev tiv thaiv kab mob. Nws yog cov tshuaj tiv thaiv loj tshaj plaws hauv lub cev thiab tsis tshua muaj ntau (5 txog 10%) dua li lwm cov tshuaj tiv thaiv. IgMs yog tsim los ntawm plasma hlwb thiab muaj nyob rau hauv cov ntshav thiab lymph kua. IgM tshwm sim raws li ib tug pentamer uas muaj tib yam hnyav thiab lub teeb chains raws li qhia nyob rau hauv daim duab 02. Muaj kaum antigen binding qhov chaw rau lub IgM. Txawm li cas los xij, vim muaj qhov tsis sib xws ntawm IgM, tsuas yog tsib qhov chaw muaj rau antigen khi. IgM yog lub luag haujlwm rau kev puas tsuaj thaum ntxov ntawm antigen thiab tswj kev kis kab mob.
Daim duab 2: Tus qauv ntawm IgG thiab IgM
IgG yog dab tsi?
IgG yog lwm hom tshuaj tiv thaiv uas tsim los ntawm cov qe ntshav dawb thiab muaj nyob rau hauv tag nrho cov kua hauv lub cev. Nws yog cov tshuaj tiv thaiv uas muaj ntau tshaj plaws hauv lub cev tiv thaiv kab mob (80%) thiab cov tshuaj tiv thaiv tsawg tshaj plaws. IgGs yog tsim nyob rau tom qab theem ntawm tus kab mob thiab nyob twj ywm nyob rau hauv lub cev los tiv thaiv cov kab mob rov qab. IgG cov tshuaj tiv thaiv muaj peev xwm hla cov placenta ntawm leej niam cev xeeb tub thiab tiv thaiv tus menyuam hauv plab los ntawm kev kis kab mob vim nws qhov me me. IgGs muaj nyob ua monomers nrog ob qhov chaw sib txuas antigen hauv txhua cov tshuaj tiv thaiv raws li qhia hauv daim duab 02.
IgM thiab IgG yog dab tsi?
IgM vs IgG |
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| IgM yog pentameric molecule uas tshwm sim thaum ntxov ntawm kev kis kab mob. | IgG yog ib qho monomeric molecule uas tshwm sim tom qab theem ntawm tus kab mob. |
| Thawj tshwm sim hauv lub cev | |
| Thawj cov tshuaj tiv thaiv yog tsim los ntawm cov plasma hlwb hauv cov menyuam hauv plab. | Qhov no tsis yog thawj cov tshuaj tiv thaiv uas tsim los ntawm cov kab mob ntshav plasma ntawm tus menyuam hauv plab. |
| IgM yog cov tshuaj tiv thaiv loj tshaj plaws tab sis qhov tsawg tshaj plaws cov tshuaj tiv thaiv hauv lub cev. | IgG yog qhov tsawg tshaj plaws thiab muaj ntau cov tshuaj tiv thaiv hauv lub cev. |
| qauv | |
| IgM yog pentameter. | IgG is a monomer. |
| Nws pom muaj nyob hauv cov ntshav thiab cov kua qaub ncaug. | Nws pom muaj nyob hauv txhua lub cev kua. |
| Antigen Binding Sites | |
| Nws muaj 10 lossis 12 qhov chaw khi rau cov tshuaj tiv thaiv. | Nws muaj ob qhov chaw khi rau antigens. |
| Placenta | |
| Vim tias nws yog cov tshuaj tiv thaiv kab mob loj dua, tsis tuaj yeem hla cov placenta. | Nws yog tib hom tshuaj tiv thaiv kab mob tuaj yeem hla cov placenta thiab tsim kev tiv thaiv ntawm tus menyuam hauv plab. |
| Presence in Colostrum | |
| IgM tsis nyob hauv lub colostrum. | IgG tam sim no nyob rau hauv lub colostrum. |
| Type | |
| Tsuas muaj ib hom IgMs. | Muaj plaub hom IgGs. |
| Immunology Test | |
| IgM qhia txog tus kabmob tam sim no. | Immunology test qhia txog qhov tshwm sim tsis ntev los no lossis yav dhau los ntawm tus kabmob. |
Summary – IgM vs IgG
Ob leeg (IgM) thiab (IgG) yog hom immunoglobulin proteins pom nyob rau hauv lub cev tiv thaiv kab mob tiv thaiv kab mob. Lawv yog cov tshuaj tiv thaiv uas tsim los ntawm cov ntshav plasma los khi nrog cov tshuaj txawv teb chaws tshwj xeeb, uas nkag mus rau hauv lub cev tom qab kis kab mob. Thaum cov tshuaj tiv thaiv no khi rau cov tshuaj tiv thaiv tshwj xeeb, lub cev tiv thaiv kab mob tuaj yeem txheeb xyuas cov kab mob sib kis thiab rhuav tshem cov kab mob.
IgM cov tshuaj tiv thaiv tshwm sim sai li sai tau thaum lub cev raug tus kab mob thaum IgG cov tshuaj tiv thaiv tshwm sim tom qab ob peb hnub ntawm tus kab mob thaum IgM cov tshuaj tiv thaiv tau ploj ntawm lub cev. Qhov no yog qhov sib txawv tseem ceeb ntawm IgM thiab IgG.
