Qhov Tseem Ceeb Qhov txawv - Celiac vs Crohn's Disease
Qhov sib txawv tseem ceeb ntawm Celiac thiab Crohn tus kab mob yog tias tus kab mob Celiac yog ib qho kab mob autoimmune uas tuaj yeem tshwm sim ntawm cov noob caj noob ces uas noj gluten ua rau kev puas tsuaj hauv cov hnyuv; Nws ua rau villus atrophy thiab malabsorption. Txawm li cas los xij, Crohn tus kab mob yog ib qho mob ntev ntawm txoj hnyuv, tshwj xeeb tshaj yog cov hnyuv thiab ileum, cuam tshuam nrog ulcers thiab fistulae. Qhov no yog yus muaj los ntawm strictures ntawm lub plab me me nrog hla lesions. Terminal ileum yog qhov chaw sib koom ua ke. Kab lus no sim piav qhia qhov txawv ntawm ob kab mob kom ntxaws ntxiv.
Celiac Disease yog dab tsi?
Thaum cov neeg muaj kab mob celiac noj cov zaub mov uas muaj gluten (cov protein muaj nyob rau hauv cov nplej, rye, thiab barley), lawv lub cev nce lub cev tiv thaiv kab mob rau lub epithelium ntawm txoj hnyuv me. Cov kev tawm tsam no ua rau muaj kev puas tsuaj ntawm villi, me me ntiv tes zoo li cov kab mob hauv cov hnyuv, uas pab txhawb kev nqus cov as-ham. Thaum lub villi puas lawm, cov as-ham tsis tuaj yeem nqus tau zoo uas ua rau malabsorption syndrome. Kab mob Celiac tuaj yeem ua rau lwm yam teeb meem kev noj qab haus huv xws li kab mob autoimmune xws li hom I ntshav qab zib mellitus thiab ntau yam sclerosis (MS), dermatitis herpetiform (khaus khaus ntawm daim tawv nqaij), anemia, osteoporosis, infertility thiab nchuav menyuam, paj hlwb xws li qaug dab peg thiab migraines, luv stature., thiab mob qog noj ntshav. Tam sim no, kev kho mob rau cov kab mob celiac yog ua raws li kev noj zaub mov tsis muaj gluten.
Tus kab mob Crohn yog dab tsi?
Crohn tus kab mob yog tshwm sim los ntawm kev sib xyaw ua ke ntawm ib puag ncig, tiv thaiv kab mob thiab kab mob hauv ib tus neeg muaj kab mob. Nws ua rau muaj cov tshuaj tiv thaiv mob ntev, uas lub cev tiv thaiv kab mob ua rau lub plab zom mov tuaj yeem raug coj mus rau microbial antigens. Nws ua rau mob plab, ntshav raws plab uas muaj ntau yam rov qab los thiab tshem tawm. Lwm yam teeb meem muaj xws li plab hnyuv strictures thiab obstruction, fistulae, abscesses. Nws kuj tseem cuam tshuam nrog ntau yam kev tshwm sim xws li qhov muag liab, mob caj dab, tshwm sim ntawm daim tawv nqaij zoo li erythema nodosum, gallstones, thiab biliary pob zeb. Kev kho mob yog los ntawm kev tiv thaiv kab mob xws li steroids, sulfasalazine, thiab mesalazine. Cov tshuaj tua kab mob kuj muaj lub luag haujlwm hauv kev tswj hwm. Kev phais yuav tsum tau muaj rau cov neeg mob nyuaj uas yuav tsum tau txiav tawm ntawm cov plab hnyuv siab raum kom txo tau cov kev cuam tshuam.
Dab tsi yog qhov txawv ntawm Celiac thiab Crohn's Disease?
Cause:
Kab Mob Celiac: Kab mob Celiac yog tshwm sim los ntawm kev tsis haum rau gluten.
Crohn's Disease: Cov kab mob Crohns yog tshwm sim los ntawm cov tshuaj tiv thaiv autoimmune tawm tsam plab hnyuv epithelium.
Kab mob Celiac:
Symptoms:
Celiac Disease: Kab mob Celiac ua rau malabsorption syndrome.
Crohn's Disease: Crohn tus kab mob ua rau rov qab thiab rov qab raws plab nrog rau lwm yam kev mob tshwm sim xws li mob caj dab, episcleritis, thiab pyoderma.
Autoantibodies:
Kab Mob Celiac: Anti-Endomysial Antibodies muaj nyob hauv qee cov neeg mob uas muaj kab mob celiac.
Crohn's Disease: Anti-Saccharomyces cerevisiae cov tshuaj tiv thaiv muaj nyob hauv qee cov neeg mob Crohn's disease.
Histology:
Kab Mob Celiac: Kab mob Celiac ua rau villous atrophy feem ntau hauv jejunum. Tsuas yog cov mucosa cuam tshuam.
Crohn's Disease: Crohn tus kab mob ua rau cov pob zeb zoo li nrog epithelid hom granuloma tsim. Nws cuam tshuam tag nrho cov txheej txheem ntawm lub plab hnyuv.
Commonest Site:
Celiac Disease: Kab mob Celiac feem ntau cuam tshuam rau jejunum.
Crohn's Disease: Crohn tus kab mob feem ntau cuam tshuam rau lub davhlau ya nyob twg.
Diagnosis:
Kab Mob Celiac: Kab mob Celiac xav tau kev kuaj mob endoscopy thiab jejunal biopsy. Kev kuaj pom autoantibody yuav txhawb kev kuaj mob.
Crohn's Disease: Crohn's disease yog kuaj pom los ntawm kev kuaj mob plab hnyuv qis thiab kuaj ntshav. Thaum lub davhlau ya nyob twg ileum tsis koom nrog cov kev tshawb fawb barium thiab CT enterography tej zaum yuav tsum tau kuaj xyuas qhov txhab mob.
Kev kho mob:
Kab Mob Celiac: Kab mob Celiac xav tau kev noj zaub mov tsis muaj gluten mus tas li.
Crohn's Disease: Crohn tus kab mob xav tau cov tshuaj tiv thaiv kab mob. Muaj cov qauv tshiab ntawm kev kho mob xws li cov tshuaj tiv thaiv kab mob monoclonal uas tab tom raug sim.
