YLeucoderma vs Vitiligo
Cov vitiligo thiab leucoderma (leukoderma) yog tib yam. Vitiligo yog lo lus kho mob rau leukoderma, thiab tsis muaj qhov sib txawv ntawm vitiligo thiab leukoderma. Michael Jackson thiab Jon Hamm muaj vitiligo. Kab lus no yuav tham txog qhov nthuav dav seb vitiligo yog dab tsi, nws qhov chaw kho mob dab tsi, cov tsos mob, ua rau, thiab kev mob tshwm sim, thiab cov kev kho mob uas nws xav tau.
Cov xim tawv nqaij yog tshwm sim los ntawm cov xim hu ua melanin uas tsim hauv melanocytes. Thaum melanocyte muaj nuj nqi deteriorates daim tawv nqaij poob nws cov xim. Qhov no hu ua vitiligo. Txawm hais tias qhov tseeb ua rau vitiligo yog qhov tsis paub, muaj ntau txoj kev xav piav qhia txog cov kab mob pathophysiology. Qee tus hais tias nws yog autoimmune, qhov twg lub cev tiv thaiv kab mob ua rau melanocytes rhuav tshem lawv. Lwm tus hais txog kev txuas caj ces. TYR noob, uas pab rhuav tshem cov qog nqaij hlav cancer hauv malignant melanoma, kuj muaj nyob rau hauv cov neeg mob vitiligo. Hauv vitiligo, TYR gene ua rau melanocytes ntau dua rau kev tiv thaiv kab mob sib kis. Oxidative stress theory qhia tias cov tshuaj lom oxygen metabolites tsim nyob rau hauv ib txwm lub cev mechanisms rhuav tshem melanocytes. Inflamation yog ib qho tshuaj tiv thaiv kab mob rau cov kab mob uas raug mob. Kev raug mob yuav yog vim muaj kab mob, kab mob los yog tshuaj. Exaggerated inflammatory tshuaj tso tawm cov tshuaj lom uas ua rau puas thiab puas melanocytes. Qee cov kab mob tau paub tias cuam tshuam rau cov tawv nqaij tshwj xeeb. Qhov no kuj tseem tuaj yeem ua lub luag haujlwm hauv vitiligo.
Muaj ob hom vitiligo. Segmental vitiligo tshwm rau ntawm ib sab nkaus xwb, tshwj xeeb tshaj yog nyob rau hauv cov cheeb tsam cuam tshuam nrog dorsal paus mov. Cov tsos, zoo li, xim, thiab loj hloov ntawm tus neeg mob mus rau tus neeg mob. Segmental vitiligo kis tau sai tab sis teb zoo rau kev kho mob. Nws tsis paub tias muaj feem xyuam nrog cov kab mob autoimmune. Tsis yog segmental vitiligo tshwm symmetrically. Muaj tsib chav sib txawv ntawm non-segmental vitilgo. Lawv yog generalized, universal, acro-facial, mucosal thiab focal vitiligo. Thaum tsuas yog ib qho me me ntawm cov tawv nqaij pigmented nrog dav dav dav vitiligo, nws yog hu ua vitiligo universalis. Acro-facial vitiligo cuam tshuam rau lub ntsej muag, ntiv tes thiab ntiv taw. Focal vitiligo yog hom kab mob hauv zos.
Ultra violet lub teeb raug thiab steroid therapy yog txoj kev kho mob tshaj plaws. Ultraviolet lub teeb pom kev tuaj yeem ua tau raws li qhov chaw ua haujlwm lossis cov txheej txheem hauv tsev. Txoj kev kho mob yuav ntev li ob peb lub lis piam. Ntev npaum li qhov chaw nyob ntawd, nws yuav siv sij hawm ntev rau kev kho mob kom tau txais txiaj ntsig. Kev tshawb fawb qhia tias phototherapy tsis txhim khu kev qha, thiab tsis muaj txoj hauv kev los rov pleev xim rau ntawm daim tawv nqaij. Psoralen tej zaum yuav ua rau ib nrab rov pigmentation thaum ntxiv rau phototherapy. Vitamin B12 thiab folic acid kuj tau pom tias muaj txiaj ntsig zoo hauv kev tshawb fawb los ntawm kev rov ua xim 50% ntawm cov neeg mob. Steroids cuam tshuam rau cov txheej txheem inflammatory ntawm lub cev txo qis melanocyte kev puas tsuaj. Tab sis kev kho mob ntev nrog cov tshuaj steroids tuaj yeem ua rau tawv nqaij tawv, plaub hau poob, thiab Cushing zoo li mob. Qee qhov kev tshawb fawb tau pom tias Tacrolimus zoo tiv thaiv vitiligo. Cosmetic camouflage tiv thaiv cov tawv nqaij uas tsis cuam tshuam tau tanned thaum raug tshav ntuj. De-pigmenting tsis cuam tshuam qhov chaw nyob rau hauv cov ntaub ntawv ntawm vitiligo universalis yog ib qho kev xaiv zaum kawg thiab lub hnub ci kev nyab xeeb yuav tsum tau ua raws li tom qab. Kev hloov pauv melanocyte yog lwm txoj kev siv tsawg dua.
