Omeprazole vs Esomeprazole
Ib qho kev tsis txaus siab tshaj plaws vim plab hnyuv yog mob plab sab sauv nrog dyspepsia, uas yog vim plab hnyuv, los yog gastro oesophageal reflux, lossis kab mob peptic ulcer. Muaj ntau cov tshuaj kho mob thoob plaws hauv ob centuries dhau los, tab sis cov tshuaj zoo tshaj plaws tuaj nyob rau hauv daim ntawv ntawm proton twj tso kua mis inhibitors. Ob leeg esomeprazole thiab omeprazole, poob rau hauv pawg no, thiab omeprazole yog suav tias yog cov tshuaj pro. Nws muaj nws cov kev ua ntawm lub parietal hlwb ntawm lub plab, uas secretes protons uas muab cov acidic xwm rau cov kua gastric. Cov tshuaj no ua rau H + / K + ATPase enzyme, khi rau nws irreversibly, ua rau muaj kev cuam tshuam ntawm acid secretion.
YOmeprazole
Yog tias koj xav txog cov qauv biochemical ntawm omeprazole nws yog ib haiv neeg sib tw. Muaj kev npaj ntawm qhov ncauj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj thiab tsiav tshuaj, thiab cov tshuaj intravenously npaj nyob rau hauv daim ntawv ntawm ib tug hmoov. Kev nqus ntawm omeprazole tshwm sim nyob rau hauv txoj hnyuv me, yog li, nws yog ib qho tseem ceeb rau kev npaj ntawm qhov ncauj kom nkag mus. Kev nqus ntawm omeprazole ua tiav hauv 3-6 teev lub sijhawm, thiab bioavailability ntawm cov tshuaj tom qab rov ua dua yog li 60%. Cov tshuaj no yuav tsum tau noj hauv lub plab khoob vim tias bioavailability cuam tshuam los ntawm cov zaub mov. Cov tshuaj no kuj muaj feem xyuam nrog cov teebmeem xws li xeev siab, mob plab, raws plab, kiv taub hau, thiab lwm yam.
YEsomeprazole
Y Yog tias koj noj esomeprazole, nws yog proton twj tso kua mis inhibitor nrog S-enantiomer ntawm cov qauv omeprazole. Lawv tuaj nyob rau hauv enteric coated daim ntawv qhov ncauj thiab nyob rau hauv cov ntaub ntawv intravenous. Nws nqus tau zoo ib yam li omeprazole. Tab sis, nws muaj bioavailability ntau dua li omeprazole. Qhov no yog ib qho tshuaj uas muaj qee yam cuam tshuam rau ntau lub enzymes ua rau nce hauv koob tshuaj warfarin thiab diazepam, thiab txo cov haujlwm ntawm clopidogrel. Cov teebmeem tsis zoo ntawm cov tshuaj no suav nrog cov teebmeem uas tau hais los saum toj no ntawm omeprazole, nrog rau kev tsis qab los noj mov, cem quav thiab lub qhov ncauj qhuav nrog ntau yam teebmeem xws li kev tsis haum tshuaj, zis tsaus nti, paresthesia, mob plab hnyav, thiab lwm yam.
Qhov txawv ntawm Omeprazole thiab Esomeprazole yog dab tsi?
Qhov zoo sib xws ntawm ob cov tshuaj no ntau dua qhov tsis sib xws. Ob leeg yog proton twj tso kua mis inhibitors, nrog zoo xws li mechanisms ntawm kev txiav txim, zoo xws li cov kev ua ntawm cov tshuaj los ntawm lub cev, nrog rau cov tshuaj zoo sib xws, thiab zoo sib xws ntawm cov kev phiv tshwm sim. Lub ntsiab tsis sib xws ntawm ob yog los ntawm cov tshuaj muaj pes tsawg leeg, ntau dua biovailability ntawm esomeprazole tshaj omeprazole, thiab txuas ntxiv ntawm cov kev mob tshwm sim vim yog esomeprazole.
Txawm hais tias tau lees paub tias muaj txiaj ntsig zoo dua li omeprazole, tsis muaj kev sim tshuaj ntsuam xyuas qhov ua tau zoo ntawm esomeprazole ntau dua li omeprazole hauv kev txo cov kua qaub. Tab sis, muaj cov kev tshawb fawb qhia tias esomeprazole muaj cov tshuaj tua kab mob zoo dua hauv kev tshem tawm H.pylori dua li omeprazole.
Txhua qhov zoo sib xws thiab qhov sib txawv no xav tau kev tshawb fawb ntxiv los qhia txog qhov ua tau zoo. Tab sis, tam sim no ob hom proton twj tso kua mis inhibitors yog siv los tswj cov kab mob gastritis, gastro oesophageal reflux thiab peptic ulcer disease.
