Zantac vs Omeprazole
Zantac (Ranitidine) thiab Omeprazole ob leeg tau muab tshuaj los kho Peptic Ulcers, Gastroesophageal Reflux Disease (GERD) thiab dyspepsia txawm hais tias muaj ntau hom kev ua thiab nrog lub hom phiaj sib txawv. Txawm li cas los xij lub ntsiab lus tseem ceeb rau kev siv ob qho tib si tseem zoo ib yam li txo qis ntawm gastric acid. Tus kab mob peptic yog yaig nyob rau hauv lub hauv ob sab phlu ntawm lub plab los yog thawj feem ntawm cov hnyuv me, ib cheeb tsam hu ua duodenum. Yog hais tias tus kab mob peptic nyob rau hauv lub plab nws yog hu ua gastric ulcer. Gastroesophageal reflux disease (GERD) yog ib yam mob uas lub plab cov ntsiab lus (khoom noj los yog kua) tawm rov qab los ntawm lub plab mus rau hauv txoj hlab pas (lub raj ntawm lub qhov ncauj mus rau lub plab). Ob leeg Zantac thiab Omeprazole pab tau rau cov mob no los ntawm inhibiting gastric acid ntau lawm.
Zantac
Zantac (Generic Name Ranitidine) yog ib qho antagonist rau H2 receptors ntawm Histamine receptors ntawm parietal Cells ntawm lub plab, uas ua rau txo qis hauv cov kua qaub los ntawm cov hlwb. Nws yog thawj zaug qhia hauv khw hauv xyoo 1981 thiab yog thawj H2 receptor antagonist. Dhau li ntawm Peptic Ulcers, Gastroesophageal Reflux Disease (GERD) thiab dyspepsia, nws kuj yog siv los ua cov tshuaj tiv thaiv hauv cov mob ua ntej thiab muab ua ntej chemotherapy ua premedication rau nws cov teebmeem antiemetic. Nws kuj yog siv los kho cov menyuam yaus reflux, qhov uas nws nyiam tshaj Omeprazole thiab lwm yam Proton Pump Inhibitors, vim nws tsis induce histologically cuam tshuam hyperplastic hloov nyob rau hauv lub parietal hlwb. Ib koob tshuaj ranitidine yog 150 mg ob zaug ib hnub.
YOmeprazole
Omeprazole belongs rau chav kawm ntawm cov tshuaj Proton Pump Inhibitors. Nws yog thawj zaug qhia nyob rau hauv kev ua lag luam nyob rau hauv 1989 los ntawm Astra Zeneca thiab txij thaum ntawd los nws tau coj lub luag hauj lwm ntawm Ranitidine nyob rau hauv kev kho mob ntawm Peptic Ulcers, Gastroesophageal Reflux Disease (GERD). Cov tshuaj no ua haujlwm los ntawm kev tawm tsam ntawm hydrogen / potassium adenosine triphosphatase enzyme system xws li H + / K + ATPase lossis feem ntau hu ua Proton Pump. Proton Pump yog lub luag haujlwm rau kev tso tawm ntawm H + ions hauv plab lumen yog li ua rau acidity ntawm lumen. Los ntawm inhibiting qhov kev txiav txim ntawm proton twj tso kua mis nws tswj cov kua qaub ncaj qha. Vim tsis muaj cov kua qaub hauv plab thiab duodenum, ulcers zoo sai dua. Omeprazole yog muab rau hauv daim ntawv tsis muaj zog. Daim ntawv no tsis muaj zog yog lipophilic los ntawm qhov xwm txheej thiab nruab nrab thiab tuaj yeem hla cov cell membranes yooj yim. Nyob rau hauv acidic ib puag ncig ntawm parietal hlwb nws tau txais protonated thiab hloov mus rau hauv active daim ntawv. Qhov no ua haujlwm rau khi rau Proton twj tso kua mis covalently thiab inactivates nws. Yog li ua rau muaj kev cuam tshuam ntawm gastric acid secretion.
Qhov txawv ntawm Zantac thiab Omeprazole
Raws li tau hais los saum toj no ob cov tshuaj zoo ib yam hauv cov tshuaj thiab muaj cov lus qhia me ntsis tom qab siv xws li kev tawm tsam ntawm gastric acid secretion. Txawm li cas los xij, pharmacologically ob cov tshuaj muaj ntau hom kev ua raws li Zantac ua ntawm H2 receptors thaum Omeprazole ua rau Proton Pump ncaj qha. Hauv kev kho mob plab thiab mob plab, Omeprazole yog qhov nyiam niaj hnub no vim tias muaj txiaj ntsig zoo dua thiab ntev ntev acid secretion inhibition. Txawm li cas los xij, Zantac tseem siv rau nws cov khoom siv tshuaj tiv thaiv raws li cov tshuaj tiv thaiv. Nws tseem tuaj yeem muab tau ua cov tshuaj sib xyaw nrog NSAIDS kom txo tau cov kua qaub. Kev siv Omeprazole mus ntev tuaj yeem ua rau muaj vitamin B12 tsis txaus vim Omeprazole cuam tshuam nws txoj kev nqus los ntawm kev txo cov acidic ib puag ncig.
Zaj lus
Ntau qhov kev sim tshuaj tau ua tiav los sib piv ob cov tshuaj no thiab cov txiaj ntsig zoo sib xws los ntawm txhua tus ntawm lawv. piv nrog ranitidine, omeprazole muab cov tsos mob sai sai tab sis tsis muaj kev txhim kho hauv kev ua tiav ntev ntawm kev kho mob sib quas ntus rau GERD thiab Peptic Ulcers. Omeprazole yuav tsum tau nyiam yog tias qhov txo qis ntawm cov tsos mob yog qhov tsim nyog tab sis nws tsis zoo tshaj rau Zantac rau kev siv mus sij hawm ntev.
