Qhov sib txawv tseem ceeb ntawm imipenem thiab meropenem yog tias imipenem yog ib qho tshuaj tua kab mob β lactam tiv thaiv kab mob ib txwm ua los ntawm cov kab mob gram-zoo cocci, thaum meropenem yog tshuaj tua kab mob β lactam rau cov kab mob kab mob feem ntau tshwm sim los ntawm gram-negative bacilli..
Imipenem thiab meropenem yog ob hom tshuaj tua kab mob uas siv los kho cov kab mob sib kis. Cov tshuaj tua kab mob yog siv los kho qee hom kab mob. Cov tshuaj tua kab mob ua haujlwm los ntawm kev tua cov kab mob lossis tiv thaiv kom tsis txhob kis mus rau lwm thaj chaw ntawm lub cev. Txawm li cas los xij, lawv tsis ua haujlwm rau txhua hom kab mob. Tsis tas li ntawd, cov tshuaj tua kab mob tsis niaj hnub siv los kho mob hauv siab, mob pob ntseg hauv cov menyuam yaus, lossis mob caj pas.
Imipenem yog dab tsi?
Imipenem yog ib qho semisynthetic thienamycin uas muaj qhov dav dav ntawm cov kab mob tua kab mob tiv thaiv kab mob gram-positive thiab gram-negative aerobic thiab anaerobic kab mob, suav nrog ntau hom kab mob ntau yam. Imipenem ruaj khov rau ntau beta-lactamase enzymes tsim los ntawm ntau cov kab mob. Nws yog ib qho tshuaj tua kab mob β lactam uas pom los ntawm Merck cov kws tshawb fawb Burton Christensen, William Leanza, thiab Kenneth Wildonger hauv xyoo 1970. Lawv muaj peev xwm tiv taus β lactamases enzymes uas tsim los ntawm ntau yam kab mob-tiv taus. Yog li ntawd, lawv ua lub luag haujlwm tseem ceeb hauv kev kho cov kab mob uas tsis tuaj yeem kho los ntawm lwm cov tshuaj tua kab mob.
Daim duab 01: Imipenem
Imipenem yog thawj patented nyob rau hauv 1975 thiab tau pom zoo rau kev kho mob nyob rau hauv 1985. Nws tau tshawb pom los ntawm ntev mus kev tshawb fawb ua nyob rau hauv kev tshawb fawb ntawm ib tug ruaj khov version ntawm lub ntuj cov khoom theinamycin. Theinamycin yog tsim los ntawm cov kab mob Streptomyces cattleya, uas muaj cov tshuaj tua kab mob. Txawm li cas los xij, nws tsis ruaj khov hauv cov tshuaj aqueous, yog li nws yog qhov tsis tsim nyog los muab nws rau cov neeg mob. Tsis tas li ntawd, imipenem tseem ceeb tshwj xeeb rau nws cov haujlwm tiv thaiv kab mob xws li Pseudomonas aeruginosa thiab Enterococcus. Tab sis nws tsis muaj zog tiv thaiv kab mob MRSA.
Meropenem yog dab tsi?
Meropenem yog tshuaj tua kab mob siv rau cov kab mob kab mob feem ntau tshwm sim los ntawm gram-negative bacilli. Nws yog muag raws li lub npe Merrem. Meropenem yog ib qho tshuaj tua kab mob β lactam siv los kho ntau yam kab mob, nrog rau cov kab mob meningitis, kab mob hauv plab, mob ntsws, sepsis, thiab anthrax. Cov kev mob me me ntawm kev siv cov tshuaj tua kab mob no yog xeev siab, raws plab, cem quav, mob taub hau, ua pob, thiab mob ntawm qhov chaw txhaj tshuaj. Cov kev mob tshwm sim hnyav dua muaj xws li Clostridioides difficile kab mob, qaug dab peg, thiab kev tsis haum tshuaj xws li anaphylaxis.
Daim duab 02: Meropenem
Meropenem yog nyob rau hauv cov tshuaj carbapenem tsev neeg. Meropenem ib txwm ua rau cov kab mob tuag los ntawm cov txheej txheem uas thaiv lawv lub peev xwm los ua cov phab ntsa ntawm tes. Cov tshuaj tua kab mob no yog thawj patented nyob rau hauv 1983. Tsis tas li ntawd, meropenem tau pom zoo thawj zaug rau kev siv tshuaj kho mob hauv Tebchaws Meskas hauv xyoo 1996. Nws tseem nyob hauv World He alth lub koom haum cov npe Cov Tshuaj Tseem Ceeb thiab tau muab cais ua cov tshuaj tseem ceeb rau tib neeg.
Imipenem thiab Meropenem zoo sib xws yog dab tsi?
- Imipenem thiab meropenem yog ob hom tshuaj tua kab mob siv los kho cov kab mob sib kis.
- Ob leeg yog cov tshuaj tua kab mob β lactam hauv cov hlab ntsha.
- Ob yam tshuaj muaj nyob hauv tsev neeg cov tshuaj carbapenem.
- Lawv tuaj yeem muab tshuaj raws li kev txhaj tshuaj.
- Ob leeg yuav ua rau muaj kev phiv.
- Lawv tso cov tshuaj pharmacokinetics zoo sib xws.
- Ob leeg yog cov tshuaj kws kho mob tau lees paub.
- Lawv nyob rau hauv lub koom haum World He alth's List of Essential Medicines.
Qhov txawv ntawm Imipenem thiab Meropenem yog dab tsi?
Imipenem yog ib qho tshuaj tua kab mob β lactam siv rau cov kab mob kab mob feem ntau tshwm sim los ntawm gram-positive cocci, thaum meropenem yog tshuaj tua kab mob β lactam siv rau cov kab mob kab mob feem ntau tshwm sim los ntawm gram-negative bacilli. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm imipenem thiab meropenem. Tsis tas li ntawd, imipenem yog thawj patented nyob rau hauv 1975, thaum meropenem yog thawj patented nyob rau hauv 1983.
Cov hauv qab no infographic nthuav tawm qhov sib txawv ntawm imipenem thiab meropenem hauv daim ntawv teev npe rau kev sib piv ntawm ib sab.
Summary – Imipenem vs Meropenem
Imipenem thiab meropenem yog ob hom tshuaj tua kab mob siv los kho cov kab mob sib kis. Lawv tuaj nyob rau hauv carbapenem tsev neeg ntawm cov tshuaj. Imipenem yog siv rau cov kab mob kab mob feem ntau tshwm sim los ntawm gram-positive cocci, thaum meropenem yog siv rau cov kab mob kab mob feem ntau tshwm sim los ntawm gram-negative bacilli. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm imipenem thiab meropenem.
