Qhov sib txawv tseem ceeb ntawm LDH thiab lactic acid yog LDH yog ib qho tseem ceeb enzyme nyob rau hauv lub cellular respiration txheej txheem thiab catalyses lub interconversion ntawm lactate rau pyruvate, thaum lactic acid yog ib tug organic acid uas yog tsim thaum qabzib tawg mus rau. tsim ATP thaum tsis muaj oxygen.
Anaerobic respiration nyob rau hauv tib neeg tshwm sim thaum lub sij hawm strenuous ce thaum tsis muaj oxygen txaus. Hauv cov txheej txheem no, pyruvic acid, uas yog cov khoom lag luam ntawm glycolysis, hloov mus rau lactic acid los ntawm LDH. Qhov no ua rau muaj kev tsim cov lactic acid, ua rau cov leeg qaug zog. Yog li ntawd, LDH thiab lactic acid yog ob lub tebchaw uas tuaj yeem pom nyob rau hauv anaerobic respiration theem ntawm cellular respiration.
LDH (Lactate Dehydrogenase) yog dab tsi?
LDH (lactate dehydrogenase) yog ib qho tseem ceeb enzyme koom nrog hauv cov txheej txheem ua pa ntawm tes. Ntawm no, nws catalyses lub interconversion ntawm lactate rau pyruvate. Nws kuj tseem ua rau cov kev sib txuas sib txuas ntawm NAD+ rau NADH. Cov enzyme no hloov cov khoom kawg ntawm glycolysis mus rau lactic acid thaum cov pa oxygen tsis tuaj lossis tsis txaus. Ntxiv mus, nws kuj catalyses qhov rov qab cov tshuaj tiv thaiv thaum lub sij hawm Cori voj voog nyob rau hauv daim siab. Qhov no enzyme muaj nyob rau hauv tag nrho cov nyob cell. Feem ntau, dehydrogenase enzyme hloov cov hydride los ntawm ib lub molecule mus rau lwm qhov.
Daim duab 01: LDH
Lub LDH nquag muaj muaj plaub lub ntsiab subunits. Nws kuj muaj tsib isoforms uas zoo ib yam li enzymatically tab sis qhia cov ntaub so ntswg sib txawv: LDH1 (lub plawv thiab lub hlwb), LDH2 (reticuloendothelial system), LDH3 (lub ntsws), LDH4 (lub raum, placenta, thiab pancreas), LDH5 (siab, leeg nqaij, thiab hlwb). Ntxiv mus, qhov tsis tshua muaj kev hloov pauv hauv cov noob tswj kev tsim cov lactate dehydrogenase ua rau muaj kev kho mob hu ua LDH deficiency. Tsis tas li ntawd, ntawm kev kuaj LDH lossis kuaj ntshav, qib siab ntawm LDH feem ntau qhia txog kev puas tsuaj ntawm cov ntaub so ntswg, uas muaj ntau yam ua rau xws li hemolytic anemia, vitamin B12 deficiency anemia, infarction, mob raum mob, mob siab kab mob, mob pancreatitis, pob txha tawg, thiab mob cancer.
YLactic Acid yog dab tsi?
Lactic acid yog cov organic acid uas tsim thaum cov piam thaj tawg los tsim ATP thaum tsis muaj oxygen. Lactic acid yog thawj zaug pom los ntawm Swedish chemist Carl Wilhelm Scheele nyob rau hauv 1780 los ntawm qaub mis nyuj. Nws muaj cov tshuaj formula ntawm CH3CH(OH)COOH. Nws yog dawb nyob rau hauv ib tug khoom lub xeev thiab ib tug colorless tov nyob rau hauv ib tug yaj lub xeev. Lactic acid yog ib qho alpha hydroxy acid (AHA) vim muaj cov pab pawg hydroxyl nyob ib sab ntawm pawg carboxyl.
Daim duab 02: Lactic Acid
Anaerobic ua pa hauv tib neeg ua rau muaj lactic acid tsim los ntawm pyruvic acid los ntawm kev ua ntawm LDH thaum lub sijhawm ua haujlwm hnyav thaum tsis muaj oxygen txaus. Ntxiv mus, lactic acid yog tsim los ntawm cov kab mob fermentation ntawm carbohydrates los yog tshuaj los ntawm acetaldehyde. Tsis tas li ntawd, cov chaw tsim khoom noj khoom haus ntxiv lactic acids rau cov khoom noj xws li qhob cij, khoom qab zib, txiv ntseej, thiab jams txhawm rau muab lawv lub neej ntev. Tsis tas li ntawd, nws yog tshwj xeeb yog siv los kho hyperpigmentation, hnub nyoog me ntsis, thiab lwm yam uas ua rau lub ntsej muag dull thiab tsis sib xws.
Dab tsi yog qhov zoo sib xws ntawm LDH thiab Lactic Acid?
- LDH thiab lactic acid yog ob lub tebchaw uas tuaj yeem txheeb pom hauv kev ua pa anaerobic
- Ob lub tebchaw ua lub luag haujlwm tseem ceeb hauv kev ua pa ntawm tes.
- Lawv tuaj yeem txheeb xyuas hauv tib neeg lub cev.
- Ob lub tebchaw ua rau ATP ntau lawm anaerobically.
- Lawv muaj kev lag luam sib txawv.
Qhov txawv ntawm LDH thiab Lactic Acid yog dab tsi?
LDH yog ib qho tseem ceeb enzyme nyob rau hauv lub cellular respiration txheej txheem, thiab nws catalyses lub interconversion ntawm lactate rau pyruvate, thaum lactic acid yog ib tug organic acid uas yog tsim thaum qabzib tau tawg los tsim ATP thaum tsis muaj oxygen. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm LDH thiab lactic acid. Tsis tas li ntawd, qhov hnyav molecular ntawm LDH yog 144,000 g / mol, thaum molecular hnyav ntawm lactic acid yog 90.08 g / mol.
Cov hauv qab no qhia txog qhov sib txawv ntawm LDH thiab lactic acid hauv daim ntawv tabular rau kev sib piv ntawm ib sab.
Summary – LDH vs Lactic Acid
LDH thiab lactic acid yog ob lub tebchaw uas tuaj yeem txheeb xyuas hauv kev ua pa anaerobic. Hauv cov txheej txheem no, pyruvic acid, uas yog cov khoom lag luam ntawm glycolysis, hloov mus rau lactic acid los ntawm LDH. LDH yog ib qho enzyme tseem ceeb hauv kev ua pa ntawm tes. Nws catalyses qhov kev hloov pauv ntawm lactate rau pyruvate. L acid yog cov organic acid uas tsim thaum cov piam thaj tawg los tsim ATP thaum tsis muaj oxygen. Yog li, qhov no qhia txog qhov sib txawv ntawm LDH thiab lactic acid.
