Qhov sib txawv tseem ceeb ntawm kev thauj mus los qeeb thiab ceev ceev yog tias kev thauj mus los qeeb qeeb yog cov txheej txheem uas thauj cov cytoskeleton Cheebtsam ntawm tus nqi tsawg dua 8 hli hauv ib hnub, thaum thauj axonal ceev yog lub tshuab uas thauj cov cytoskeleton Cheebtsam ntawm ib hnub. tus nqi ntawm 200-400 mm ib hnub los yog 2-5μm ib ob.
Axonal thauj yog cov txheej txheem ntawm tes uas yog lub luag haujlwm rau kev txav ntawm cov organelles thiab molecules sib txawv raws li axon ntawm cov neuron. Nws tseem hu ua axoplasmic thauj lossis axoplasmic flow. Ob hom kev thauj axonal yog qeeb axonal thauj thiab ceev axonal thauj.
Kev thauj mus los qeeb Axonal yog dab tsi?
Slow axonal thauj yog qhov thauj qeeb ntawm cytoskeleton polymers thiab cytosolic protein complexes nrog axons ntawm neurons ntawm tus nqi tsawg dua 8 hli ib hnub. Advanced imaging cov tswv yim tau coj mus rau kev nkag siab ntawm qeeb axonal thauj mechanism nyob rau hauv xyoo tas los no. Cov txheej txheem kev yees duab no suav nrog cov txheej txheem fluorescent labeling xws li fluorescence microscopy.
Daim duab 01: Axonal Transport
Cov cytoskeleton Cheebtsam nyob rau hauv lub axonal thauj mechanism siv sij hawm ntev dua mus raws li qhov ntev ntawm lub axon. Tam sim no nws tau pom tias kev thauj mus los qeeb axonal tau tshwm sim sai, tab sis vim muaj kev ncua tsis tu ncua, tag nrho cov kev thauj mus los yuav qeeb dua. Hom kev thauj no yog hu ua "Stop and Go" qauv. Cov qauv no feem ntau siv tau rau kev thauj mus los ntawm cytoskeleton protein neurofilament. Lub zog ntawm cytosolic proteins nyob rau hauv qeeb axonal thauj tshwm sim nyob rau hauv ib tug complex daim ntawv.
Kev thauj mus los ceev Axonal yog dab tsi?
Kev thauj mus los nrawm nrawm yog qhov nrawm nrawm ntawm daim nyias nyias vesicles thiab cov ntsiab lus txheeb ze nyob deb ntawm ib qho axon hauv cov neuron ntawm tus nqi ntawm 200-400mm ib hnub twg lossis 2-5μm ib ob. Thaum pib ntawm kev tshawb fawb biochemical thiab morphological, nws tau pom tseeb tias cov ntaub ntawv txav mus rau hauv kev thauj mus los ceev ceev cuam tshuam nrog cov kab mob membrane-bound organelles. Cov ntaub ntawv no muaj xws li mitochondria, membrane-associated receptors, proteins, neurotransmitters, synaptic vesicles, thiab neuropeptides. Qhov luaj li cas ntawm cov khoom los yog daim nyias nyias organelle cuam tshuam ncaj qha rau tus nqi thauj.
Cov ntaub ntawv me me me me yuav txav mus sai, thiab cov organelles xws li mitochondria txav qeeb. Lub hauv paus ntsiab lus ntawm kev thauj mus los ceev axonal tau nkag siab ntau xyoo dhau los. Kev thauj ceev axonal muab cov khoom siv ceev ceev ntawm cov khoom sib txuas tshiab uas tseem ceeb rau kev saib xyuas thiab kev ua haujlwm ntawm cov paj hlwb.
Dab tsi yog qhov zoo sib xws ntawm Slow thiab Fast Axonal Transport?
- Kev thauj mus los qeeb thiab nrawm yog cov txheej txheem thauj khoom uas tshwm sim hauv cov neuron.
- Ob lub tshuab thauj khoom raws qhov ntev ntawm axon.
- Lawv xa khoom zoo uas tsis tuaj yeem thauj mus los ntawm kev sib kis.
Dab tsi yog qhov sib txawv ntawm Slow thiab Fast Axonal Transport?
Kev thauj mus los qeeb axonal yog kev thauj mus los ntawm cytoskeleton Cheebtsam ntawm tus nqi tsawg dua 8 hli hauv ib hnub, thaum thauj axonal ceev yog kev thauj mus los ntawm cytoskeleton Cheebtsam ntawm tus nqi ntawm 200-400mm ib hnub twg lossis 2-5μm ib ob. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm kev thauj mus los qeeb thiab ceev axonal. Ntxiv mus, qeeb axonal transports nqa cytoskeleton polymers thiab protein complexes, thaum ceev axonal transports nqa mitochondria, membrane-associated receptors, neurotransmitters proteins, thiab synaptic vesicles.
Cov hauv qab no infographic nthuav tawm qhov sib txawv ntawm kev thauj mus los qeeb thiab ceev axonal hauv daim ntawv tabular rau ib sab ntawm kev sib piv.
Summary – Slow vs Fast Axonal Transport
Axonal thauj yog cov txheej txheem ntawm tes uas yog lub luag haujlwm rau kev txav ntawm cov organelles thiab molecules sib txawv raws li axon ntawm cov neuron. Kev thauj mus los qeeb axonal tshwm sim ntawm tus nqi qeeb, thaum thauj axonal ceev tshwm sim ntawm tus nqi nrawm thaum thauj cov ntaub ntawv raws li axon ntawm neuron. Cov cytoskeleton Cheebtsam nyob rau hauv qeeb axonal thauj coj qhov chaw ntawm tus nqi ntawm tsawg tshaj li 8 hli ib hnub twg. Thaum lub sij hawm ceev axonal thauj, cov ntaub ntawv txav ntawm tus nqi ntawm 200-400mm ib hnub twg los yog 2-5μm ib ob. Ntxiv mus, qeeb axonal transports nqa cytoskeleton polymers thiab protein complexes, thaum ceev axonal transports nqa mitochondria, daim nyias nyias receptors, neurotransmitters proteins, thiab synaptic vesicles. Yog li, qhov no qhia txog qhov sib txawv ntawm kev thauj mus los qeeb thiab ceev ceev.
