Qhov txawv ntawm ERK1 thiab ERK2 yog tias ERK1 yog mitogen-activated protein kinase encoded los ntawm MAPK3 noob, thaum ERK2 yog mitogen-activated protein kinase encoded los ntawm MAPK1 noob.
Mitogen-activated protein kinase (MAPK lossis MAP kinase) yog hom protein uas tshwj xeeb rau cov amino acids xws li serine thiab threonine. Muaj ntau ntau mitogen-activated protein kinases (ERKs, JNKs, P38s). MAPKs feem ntau koom nrog hauv kev taw qhia cascades hauv cov lus teb ncaj qha ntawm tes rau ntau qhov sib txawv ntawm stimuli xws li mitogens, osmotic stress, heat shock, thiab proinflammatory cytokines. Tsis tas li ntawd, lawv tswj hwm ntau lub zog ntawm tes xws li kev loj hlob, kev nthuav qhia noob, kev sib txawv, mitosis, cell ciaj sia taus, thiab apoptosis. ERK1 thiab ERK2 yog ob isoforms ntawm ERK mitogen-activated protein kinase.
Cov ntsiab lus tseem ceeb
1. Txheej txheem cej luam thiab Qhov Tseem Ceeb Qhov txawv
2. ERK1 yog dab tsi
3. ERK2 yog dab tsi
4. Zoo sib xws - ERK1 thiab ERK2
5. ERK1 vs ERK2 in Tabular Form
6. Summary – ERK1 vs ERK2
ERK1 yog dab tsi?
Extracellular signal-regulated kinase 1 (ERK1) yog ib qho mitogen-activated protein kinase uas yog encoded los ntawm MAPK3 noob. Nws tseem hu ua mitogen-activated protein kinase 3 lossis P44MAPK. ERK1 protein yog ib tug tswv cuab ntawm mitogen-activated protein kinase tsev neeg. Cov protein no ua nyob rau hauv lub teeb liab cascade uas tswj hwm ntau cov txheej txheem ntawm tes xws li kev loj hlob, kev sib txawv, thiab kev loj hlob ntawm tes hauv kev teb rau ntau yam stimuli sab nraud. Feem ntau, qhov kinase no yog qhib los ntawm cov dej ntws kinases. Tom qab ua haujlwm, nws hloov mus rau hauv lub nucleus, qhov twg nws phosphorylates lwm lub hom phiaj nuclear. ERK1 protein tseem ceeb heev.
Daim duab 01: MAPK Pathway
Ntxiv mus, nws tau raug txheeb xyuas tias MAPK3 noob, nrog rau IRAK3, raug tua los ntawm ob lub microRNAs uas tau ua haujlwm tom qab mob khaub thuas A tus kab mob ntawm tib neeg lub ntsws hlwb. Qhov no qhia qhov tseem ceeb ntawm ERK1 protein nyob rau hauv cellular functions. Tsis tas li ntawd, txoj kev tshawb fawb tsis ntev los no tau qhia txog qhov tseem ceeb ntawm ERK1/2 txoj cai raws li lub hom phiaj kho mob rau kev kho tuberous sclerosis (TS).
ERK2 yog dab tsi?
Extracellular signal-regulated kinase 2 (ERK2) yog ib qho mitogen-activated protein kinase uas yog encoded los ntawm MAPK1 noob. Cov protein no tseem hu ua mitogen-activated protein kinase 1 lossis p42MAPK. ERK2 yog ib tug tswv cuab ntawm MAP kinase tsev neeg. Feem ntau, nws ua raws li kev sib koom ua ke rau ntau yam kev qhia txog biochemical thiab koom nrog ntau yam txheej txheem ntawm tes xws li kev loj hlob, kev sib txawv, kev hloov pauv, thiab kev loj hlob. Cov protein kinase no tau qhib ua haujlwm tom qab phosphorylation los ntawm cov dej ntws kinases. Tom qab activated, nws translocates mus rau lub nucleus ntawm lub hlwb stimulated. Tom qab ntawd, ERK2 phosphorylates lwm lub hom phiaj nuclear. Ntxiv mus, ERK2 protein muaj ntau qhov chaw amino acid uas yog phosphorylated thiab ubiqutinated.
Daim duab 02: ERK2
Qee qhov kev tshawb fawb tau siv cov qauv kab mob los kawm txog kev ua haujlwm ntawm MAPK1 noob muaj nuj nqi. Ib qho piv txwv ntawm txoj kev tshawb fawb no yog ib kab kab nas hu ua Mapk1tm1a(EUCOMM)Wtsi Txoj kev tshawb no tau ua pov thawj tias kev hloov pauv ntawm MAPK 1 noob ua rau muaj qhov txawv txav. Ntxiv mus, kev hloov pauv ntawm MAPK1 noob kuj tau pom qee lub luag haujlwm hauv T cell-dependent antibody ntau lawm thiab T cell txoj kev loj hlob. Tsis tas li ntawd, nws kuj tau txheeb xyuas tias MAPK1 gene mutation nyob rau hauv neural progenitor hlwb ntawm kev tsim cortex ua rau txo qis ntawm cortical thickness thiab txo kev loj hlob ntawm neural progenitor hlwb. Clinically, ERK2 protein ua haujlwm tseem ceeb heev vim tias kev hloov pauv hauv MAPK1 noob muaj feem cuam tshuam rau ntau hom mob qog noj ntshav.
Qhov Zoo sib xws ntawm ERK1 thiab ERK2 yog dab tsi?
- ERK1 thiab ERK2 yog ob isoforms ntawm ERK mitogen-activated protein kinase.
- Ob leeg cov proteins ib txwm koom nrog hauv kev taw qhia cascades.
- Cov proteins no tau qhib rau hauv cov lus teb ncaj qha ntawm tes mus rau ntau hom stimuli xws li mitogens.
- Ob leeg cov proteins koom nrog hauv kev tswj cov txheej txheem ntawm tes xws li kev loj hlob, kev sib txawv, kev tswj hwm kev hloov pauv, thiab kev loj hlob.
- Tom qab ua kom tiav, ob qho tib si proteins hloov mus rau lub nucleus thiab phosphorylate lwm lub hom phiaj nuclear.
- Cov protein ntau ntawm ERKI thiab ERK2 yog 84% zoo ib yam.
Qhov txawv ntawm ERK1 thiab ERK2 yog dab tsi?
ERK1 yog mitogen-activated protein kinase coded los ntawm MAPK3 noob, thaum ERK2 yog mitogen-activated protein kinase coded los ntawm MAPK1 noob. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm ERK1 thiab ERK2. Tsis tas li ntawd, ERK1 protein nyob hauv tib neeg yog qhov sib piv loj, thaum ERK2 protein hauv tib neeg yog qhov sib piv me me.
Cov hauv qab no infographic nthuav tawm qhov sib txawv ntawm ERK1 thiab ERK2 hauv daim ntawv teev npe rau ib sab ntawm kev sib piv.
Summary – ERK1 vs ERK2
ERK1 thiab ERK2 yog ob isoforms ntawm ERK mitogen-activated protein kinase. MAPK3 gene codes rau ERK1 thaum MAPK1 noob codes rau ERK2. Ob leeg ERK1 thiab ERK2 yog cov khoom tseem ceeb hauv kev taw qhia cascades. Yog li, qhov no qhia txog qhov sib txawv ntawm ERK1 thiab ERK2.
