Qhov sib txawv tseem ceeb ntawm carbamazepine thiab oxcarbazepine yog tias carbamazepine hloov mus rau hauv epoxide metabolite thaum nws cov metabolism, hos oxcarbazepine hloov mus rau hauv nws cov monohydroxy derivative.
Carbamazepine yog ib qho tshuaj tiv thaiv kab mob muaj txiaj ntsig hauv kev kho mob vwm thiab mob neuropathic. Oxcarbazepine yog ib yam tshuaj pab kho mob qaug dab peg. Cov tshuaj no yog ob yam tshuaj tseem ceeb uas muaj cov qauv zoo sib xws tab sis txawv ntawm txoj hauv kev metabolic.
YCarbamazepine yog dab tsi?
Carbamazepine yog ib qho tshuaj tiv thaiv kab mob muaj txiaj ntsig hauv kev kho mob vwm thiab mob neuropathic. Cov tshuaj no yog muag raws li lub npe Tegretol. Cov tshuaj no muaj txiaj ntsig zoo li kev kho mob ntxiv hauv schizophrenia. Ntxiv mus, nws yog ib qho tseem ceeb ua tus neeg sawv cev thib ob hauv kev puas siab puas ntsws bipolar. Tsis tas li ntawd, cov tshuaj no pom zoo ua haujlwm zoo nrog phenytoin thiab valproate hauv focal thiab qaug dab peg. Txawm li cas los xij, nws tsis zoo rau kev tsis tuaj lossis myoclonic qaug dab peg.
Daim duab 01: Cov Qauv Tshuaj ntawm Carbamazepine
Xyoo 1953, Swiss chemist hu ua W alter Schindler nrhiav pom carbamazepine. Cov tshuaj no tuaj rau lub lag luam thawj zaug nyob rau hauv 1962. Tsis tas li ntawd, nws muaj nyob rau hauv lub lag luam raws li ib tug generic tshuaj.
Kev tswj hwm ntawm carbamazepine tuaj yeem ua rau qhov ncauj. Lub bioavailability ntawm cov tshuaj no yog hais txog 100%, thiab nws cov protein binding peev xwm ntawm 70-80%. Cov metabolism tshwm sim nyob rau hauv daim siab, thiab raws li metabolites, active epoxides tsim. Kev tshem tawm ib nrab ntawm lub neej yog nyob ib ncig ntawm 36 teev, thiab kev tso tawm tshwm sim los ntawm cov zis thiab quav.
Feem ntau, peb siv carbamazepine rau kev kho mob qaug dab peg thiab mob neuropathic. Peb tuaj yeem siv cov tshuaj no tawm ntawm daim ntawv lo raws li kev kho mob thib ob rau kev puas siab puas ntsws bipolar, thiab peb kuj tuaj yeem siv nrog cov tshuaj tiv thaiv kev puas siab puas ntsws thaum kho tus mob no nrog cov tshuaj antipsychotic ib leeg tsis muab qhov xav tau.
Oxcarbazepine yog dab tsi?
Oxcarbazepine yog ib yam tshuaj pab kho mob qaug dab peg. Nws yog muag raws li lub npe lag luam Trileptal. Thaum kho mob qaug dab peg, peb tuaj yeem siv rau ob qho tib si focal qaug dab peg thiab qaug dab peg. Ntxiv mus, peb tuaj yeem siv nws ib leeg lossis ua kev kho ntxiv rau cov neeg muaj kev puas siab puas ntsws bipolar uas tsis teb rau lwm yam kev kho mob. Txoj kev ntawm kev tswj cov tshuaj no yog qhov ncauj.
Daim duab 02: Cov Qauv Tshuaj ntawm Oxcarbazepine
Lub bioavailability ntawm oxcarbazepine yog kwv yees li 95%, thiab nws cov metabolism tshwm sim hauv lub siab thaum muaj cytosolic enzymes thiab glucuronic acid. Kev tshem tawm ib nrab-lub neej ntawm oxcarbazepine yog 1-5 teev, thiab qhov tso tawm tshwm sim hauv lub raum.
Muaj qee qhov kev mob tshwm sim ntawm oxcarbazepine, xws li xeev siab, ntuav, kiv taub hau, tsaug zog, pom ob lub qhov muag, thiab teeb meem taug kev. Txawm li cas los xij, muaj qee qhov kev mob tshwm sim hnyav: anaphylaxis, teeb meem hauv siab, mob pancreatitis, kev xav tua tus kheej, thiab lub plawv dhia tsis zoo. Ntxiv mus, siv cov tshuaj no thaum cev xeeb tub tuaj yeem ua mob rau tus menyuam; Ntxiv mus, nws tsis pom zoo thaum pub niam mis.
Daim ntawv pov thawj rau oxcarbazepine tau txais hauv xyoo 1969, thiab nws tau los rau hauv kev lag luam thawj zaug hauv xyoo 1990 rau kev siv kho mob. Nws muaj nyob rau hauv lub lag luam raws li ib tug generic tshuaj.
Qhov txawv ntawm Carbamazepine thiab Oxcarbazepine yog dab tsi?
Carbamazepine thiab oxcarbazepine yog ob yam tshuaj tseem ceeb uas muaj cov qauv zoo sib xws tab sis txawv ntawm txoj hauv kev metabolic. Qhov sib txawv tseem ceeb ntawm carbamazepine thiab oxcarbazepine yog tias carbamazepine hloov mus rau hauv epoxide metabolite thaum nws cov metabolism, hos oxcarbazepine hloov mus rau hauv nws cov monohydroxy derivative.
Hauv qab no yog cov ntsiab lus ntawm qhov sib txawv ntawm carbamazepine thiab oxcarbazepine hauv daim ntawv teev npe rau ib sab ntawm kev sib piv.
Summary – Carbamazepine vs Oxcarbazepine
Carbamazepine yog cov tshuaj tiv thaiv kab mob muaj txiaj ntsig hauv kev kho mob vwm thiab mob neuropathic. Oxcarbazepine yog ib yam tshuaj pab kho mob qaug dab peg. Qhov sib txawv tseem ceeb ntawm carbamazepine thiab oxcarbazepine yog tias carbamazepine hloov mus rau hauv epoxide metabolite thaum nws cov metabolism, thaum oxcarbazepine hloov mus rau hauv nws cov monohydroxy derivative.
