Qhov sib txawv tseem ceeb ntawm HTLV 1 thiab 2 yog HTLV-1 yog ib hom kab mob deltaretrovirus uas ua rau cov neeg laus T cell leukemia thiab mob hlwb hu ua HTLV-1 cuam tshuam myelopathy, thaum HTLV-2 yog hom deltaretrovirus uas Nws yog ib qho tseem ceeb uas tsis yog-pathogenic tab sis tsis tshua ua rau cov kab mob neurological xws li tropical lossis spastic ataxia.
Tus kab mob tib neeg T lymphotropic (HTLV) tsev neeg ntawm cov kab mob yog ib pawg ntawm cov kab mob retroviruses uas tuaj yeem kis tau rau tib neeg thiab cov qub ntiaj teb liab. Plaub HTLVs uas muaj peev xwm kis tau rau tib neeg tau raug txheeb xyuas txog tam sim no. Lawv yog HTLV-1, HTLV-2, HTLV-3, thiab HTLV-4. HTLV-1 thiab HTLV-2 yog delta retroviruses nrog cov qauv genome zoo sib xws thiab tag nrho nucleotide homology ntawm kwv yees li 70%.
Cov ntsiab lus tseem ceeb
1. Txheej txheem cej luam thiab Qhov Tseem Ceeb Qhov txawv
2. HTLV 1 yog dab tsi
3. HTLV 2 yog dab tsi
4. Zoo sib xws – HTLV 1 and 2
5. HTLV 1 vs 2 in Tabular Form
6. Summary – HTLV 1 vs 2
HTLV 1 yog dab tsi?
Human T lymphotropic virus type 1 (HTLV-1) yog tus kab mob retrovirus ntawm tib neeg HTLV tsev neeg uas tau cuam tshuam rau ntau yam kab mob, suav nrog cov neeg laus T cell lymphoma (ATL), HTLV-1 cuam tshuam myelopathy, uveitis, Strongyloides stercoralis hyper kab mob thiab lwm yam kab mob. Nws tau kwv yees tias kwv yees li 1 txog 5% ntawm cov neeg mob muaj mob qog noj ntshav vim yog kis tus kab mob HTLV-1 hauv lawv lub neej.
Figure 01: HTLV 1
Tus Neeg Laus T cell lymphoma tau pom nyob rau xyoo 1977 hauv Nyij Pooj. Thaum lub sij hawm, cov tsos mob ntawm tus neeg laus T cell lymphoma txawv ntawm lwm yam lymphomas. Yog li, nws tau pom tias cov neeg laus T cell lymphoma yog tshwm sim los ntawm kev kis tus kab mob retrovirus hu ua ATLV. Tom qab ntawd, kev tshawb fawb pom tau tias tus kab mob retrovirus yog ua rau cov neeg laus T cell lymphoma. Tus kab mob retrovirus tam sim no hu ua HTLV-1. Qhov no yog vim tias tom qab kev tshawb fawb tau ua pov thawj tias ATLV yog tib yam li thawj zaug pom tib neeg retrovirus hu ua HTLV los ntawm Bernard Poiesz thiab Francis Ruscetti hauv chav kuaj ntawm Robert C. Gallo ntawm National Cancer Institute hauv Asmeskas. Tsis tas li ntawd, HTLV-1 belongs rau genus deltaretrovirus thiab muaj qhov zoo-sensitive RNA genome. Thaum lub sij hawm ntawm kev koom ua ke rau hauv tus tswv tsev genome, qhov RNA no thim rov qab rau hauv DNA.
HTLV 2 yog dab tsi?
HTLV-2 yog ib hom kab mob deltaretrovirus uas yog qhov tseem ceeb tsis yog kab mob tab sis tsis tshua muaj kab mob hauv paj hlwb xws li tropical lossis spastic ataxia. Nws sib koom kwv yees li 70% genomic zoo sib xws nrog HTLV-1. Nws tau pom los ntawm Robert Gallo thiab cov npoj yaig.
Figure 02: HTLV-2
HTLV-2 muaj ntau ntawm cov neeg hauv paus txawm hauv tebchaws Africa thiab Khab-Asmeskas pab pawg hauv Central thiab South America. Ntxiv mus, nws tseem tuaj yeem pom hauv cov neeg siv tshuaj yeeb hauv Tebchaws Europe thiab North America. Tsis tas li ntawd, nws tuaj yeem dhau los ntawm leej niam mus rau tus menyuam los ntawm cov kua mis niam thiab caj ces zoo los ntawm leej niam leej txiv. HTLV-1 thiab HTLV-2 sib txawv hauv lawv cov kab mob pathogenic. HTLV-2 siv GLUT-1 thiab NRPI cellular receptors rau lawv nkag.
Qhov Zoo sib xws ntawm HTLV 1 thiab 2 yog dab tsi?
- HTLV-1and HTLV-2 yog delta retroviruses nrog cov qauv genome zoo sib xws.
- Ob leeg muaj tag nrho nucleotide homology ntawm kwv yees li 70%.
- Lawv zwm rau genus deltaretrovirus.
- Ob leeg muaj ib leeg-stranded RNA ua lawv cov khoom siv caj ces.
- Lawv muaj 9 kbp genome.
- Ob tus kab mob delta tuaj yeem kuaj tau los ntawm kev kuaj ntshav.
- Lawv tau tshawb pom hauv Robert Gallo lub chaw kuaj mob ntawm National Cancer Institute, Tebchaws Asmeskas.
- Ob tus kab mob delta muaj cov qauv sib kis, xws li kev pub niam mis thiab kev sib deev.
Qhov txawv ntawm HTLV 1 thiab 2 yog dab tsi?
HTLV-1 yog ib hom kab mob deltaretrovirus uas ua rau cov neeg laus T cell leukemia thiab mob paj hlwb hu ua HTLV-1 txuam nrog myelopathy, thaum HTLV-2 yog ib hom kab mob deltaretrovirus uas tseem ceeb tsis yog kab mob tab sis tsis tshua muaj kab mob hauv paj hlwb. xws li tropical lossis spastic ataxia. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm HTLV 1 thiab 2. Tsis tas li ntawd, HTLV-1 xav tau heparan sulfate proteoglycans rau cell nkag, thaum HTLV-2 xav tau GLUT-1 thiab NRPI cellular receptors rau cell nkag.
Cov hauv qab no infographic nthuav tawm qhov sib txawv ntawm HTLV 1 thiab 2 hauv daim ntawv teev npe rau ib sab ntawm kev sib piv.
Summary – HTLV 1 vs 2
HTLV-1and HTLV-2 yog delta retroviruses nrog cov qauv genome zoo sib xws thiab tag nrho nucleotide homology ntawm kwv yees li 70%. HTLV-1 ua rau cov neeg laus T cell leukemia thiab mob hlwb hu ua HTLV-1-associated myelopathy. HTLV-2 yog qhov tseem ceeb tsis yog kab mob tab sis tsis tshua ua rau cov kab mob neurological xws li tropical lossis spastic ataxia. Yog li, qhov no yog qhov txawv ntawm HTLV-1 thiab HTLV-2.
