Qhov sib txawv tseem ceeb ntawm erythropoietin alpha thiab beta yog tias erythropoietin alpha yog glycoprotein hormone uas muaj qhov hnyav dua molecular, thaum erythropoietin beta yog glycoprotein hormone uas muaj qhov hnyav dua molecular.
Muaj plaub tam sim no muaj erythropoiesis-stimulating agents (ESA) uas tsim los ntawm recombinant DNA technology. Lawv yog erythropoietin alpha, beta, zeta, thiab omega. Peb tawm ntawm plaub (alpha, beta, omega) yog tsim los ntawm cov amino acid zoo ib yam tab sis muaj qhov sib txawv me ntsis hauv glycosylation. Glycosylation sib txawv raws li qhov tshwm sim ntawm hom thiab tus tswv tsev ntawm tes tshwj xeeb sib txawv hauv cov txheej txheem tsim khoom.
Erythropoietin Alpha yog dab tsi?
Erythropoietin alpha yog glycoprotein hormone uas muaj qhov hnyav dua molecular. Nws yog tib neeg erythropoietin hormone tsim nyob rau hauv cell kab lis kev cai siv recombinant DNA technology. Erythropoietin alpha tau tso cai los ntawm European Medicines Agency nyob rau hauv 2007. Feem ntau, erythropoietin alpha stimulates erythropoiesis los ntawm kev nce cov qe ntshav liab. Nws yog siv rau kev kho mob ntawm anemia feem ntau cuam tshuam nrog lub raum tsis ua haujlwm ntev. Nws kuj tseem siv tau los txo cov kev xav tau ntawm cov neeg laus uas tau txais kev kho mob rau cov qog nqaij hlav, malignant lymphoma, ntau yam myeloma, thiab cov neeg uas muaj kev pheej hmoo ntawm kev tso ntshav raws li kev soj ntsuam los ntawm lawv cov xwm txheej (piv txwv li, kab mob plawv, mob ntshav qab zib ua ntej ntawm lub cev. pib chemotherapy).
Daim duab 01: Erythropoietin Alpha
Erythropoietin alpha yog tsim thiab ua lag luam los ntawm Amgen raws li lub npe Epogen, thaum lub tuam txhab Johnson & Johnson cov chaw muag khoom Jansssen Biotech muag tib cov tshuaj raws li lub npe Procrit raws li daim ntawv tso cai cov khoom lag luam. Qhov nruab nrab ntawm cov tshuaj no rau ib tus neeg mob hauv Teb Chaws Asmeskas yog $ 8, 447 hauv xyoo 2009. Feem ntau, erythropoietin alpha tau txais txiaj ntsig zoo. Txawm li cas los xij, cov kev mob tshwm sim muaj xws li ntshav siab, mob taub hau, ua tsis taus pa ntawm migraine, mob pob qij txha, thiab txhaws ntawm qhov chaw txhaj tshuaj. Cov kev mob tshwm sim tsis tshua muaj xws li stinging ntawm qhov chaw txhaj tshuaj thiab cov tsos mob zoo li mob khaub thuas.
YErythropoietin Beta yog dab tsi?
Erythropoietin beta yog glycoprotein hormone nrog qhov hnyav dua molecular. Txawm hais tias erythropoietin alpha thiab erythropoietin beta zoo ib yam nrog rau cov yam ntxwv ntawm molecular thiab cov ntaub ntawv pharmacokinetic, erythropoietin beta muaj qis dua ntawm sialylated glycan residues thiab tejzaum nws pom pharmacokinetic zoo xws li lub davhlau ya nyob twg ntev dua tshem tawm ib nrab-lub neej.
Daim duab 02: Erythropoietin Beta
Cov tshuaj no yog siv los kho cov ntshav ntshav rau cov neeg uas muaj mob raum ntev ntev xws li mob raum mob ntev. Erythropoietin beta kuj tseem pab txo qis kev xav tau ntawm cov ntshav. Nws yog ib tug hluavtaws recombinant daim ntawv ntawm erythropoietin hormone. Cov protein no txhawb kev tsim cov qe ntshav liab. Erythropoietin beta yog muag raws li lub npe ntawm NeoRecormon. Nws yog ib qho ntawm cov tshuaj hauv World He alth Organization's List of Essential Medicines. Txawm li cas los xij, nws muaj ntau yam kev mob tshwm sim, nrog rau mob taub hau, mob lub cev, raws plab, lossis ntuav.
Dab tsi zoo sib xws ntawm Erythropoietin Alpha thiab Beta?
- Erythropoietin alpha thiab beta yog ob hom recombinant erythropoiesis-stimulating agents.
- Erythropoietin alpha thiab erythropoietin beta zoo ib yam nrog rau cov yam ntxwv molecular thiab cov ntaub ntawv tshuaj pharmacokinetic.
- Ob qho tshuaj yog tsim los ntawm cov amino acid zoo ib yam.
- Cov tshuaj no yog siv los kho cov ntshav ntshav rau cov neeg uas muaj mob raum ntev ntev xws li kab mob raum ntev, thiab lawv kuj pab txo qis kev xav tau ntshav ntxiv.
- Lawv nyob rau hauv Lub Koom Haum Ntiaj Teb Kev Noj Qab Haus Huv Cov Npe Cov Tshuaj Tseem Ceeb.
Qhov txawv ntawm Erythropoietin Alpha thiab Beta yog dab tsi?
Erythropoietin alpha yog glycoprotein hormone uas muaj qhov hnyav dua molecular, thaum erythropoietin beta yog glycoprotein hormone uas muaj qhov hnyav dua molecular. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm erythropoietin alpha thiab beta. Tsis tas li ntawd, erythropoietin alpha muaj ntau dua ntawm sialylated glycan residues, thaum erythropoietin beta muaj tsawg dua ntawm sialylated glycan residues.
Cov ntawv qhia hauv qab no nthuav tawm qhov sib txawv ntawm erythropoietin alpha thiab beta hauv daim ntawv tabular rau ib sab ntawm kev sib piv.
Summary – Erythropoietin Alpha vs Beta
Erythropoietin alpha thiab beta yog ob hom recombinant erythropoiesis-stimulating agents (ESA). Erythropoietin alpha yog ib qho glycoprotein hormone nrog qhov hnyav dua molecular, thaum erythropoietin beta yog glycoprotein hormone nrog qhov hnyav dua molecular. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm erythropoietin alpha thiab beta.
