Qhov sib txawv tseem ceeb ntawm alpha thiab beta oxidation yog tias alpha oxidation feem ntau tshwm sim hauv lub hlwb thiab daim siab qhov twg ib qho atom carbon atom poob rau hauv daim ntawv ntawm cov pa roj carbon dioxide molecule, whereas beta oxidation txheej txheem tsuas yog nyob rau hauv lub mitochondria. matrix qhov twg ob-carbon units raug tso tawm raws li acetyl CoA ib lub voj voog.
Alpha oxidation yog ib txoj hauv kev uas qee cov roj fatty acids tau tawg los ntawm kev tshem tawm ib qho carbon los ntawm carboxyl kawg ntawm cov molecule. Beta oxidation yog txheej txheem catabolic uas fatty acid molecules tau tawg hauv cytosol ntawm prokaryotes thiab hauv mitochondria hauv eukaryotes, tsim acetyl CoA, NADH, thiab FADH2.
Alpha Oxidation yog dab tsi?
Alpha oxidation yog ib txoj hauv kev uas qee cov roj fatty acids tau tawg los ntawm kev tshem tawm ib qho carbon los ntawm carboxyl kawg ntawm cov molecule. Qhov no tuaj yeem tshwm sim hauv tib neeg vim nws muaj txiaj ntsig zoo hauv peroxisomes rau kev zom cov zaub mov phytanic acid uas tsis tuaj yeem ua rau beta oxidation (qhov no yog vim yog beta-methyl ceg hauv cov molecule) rau hauv pristanic acid. Tom qab ntawd, pristanic acid tuaj yeem tau txais acetyl-CoA, uas tom qab ntawd tig mus rau hauv cov khoom beta-oxidzed yielding propionyl-CoA.
Daim duab 01: Cov txheej txheem Alpha Oxidation nrog cov kauj ruam Enzymatic
Nws suav hais tias alpha-oxidation tshwm sim hauv peroxisomes. Muaj plaub kauj ruam tseem ceeb hauv cov txheej txheem no. Ua ntej, phytanic acid tau txuas nrog CoA, tsim phytanoyl CoA. Tom ntej no, phytanoyl CoA raug oxidation los ntawm phytanoyl CoA dioxygenase nrog kev siv ferrous ions thiab oxygen gas. Cov kauj ruam no yields 2-hydroxyphytanoyl-CoA. Hauv cov kauj ruam thib peb, 2-hydroxyphytanoyl-CoA cleave rau hauv pristanal thiab formyl CoA los ntawm 2-hydroxyphytanoyl-CoA lyase hauv TPP-dependent cov tshuaj tiv thaiv. Thaum kawg, raws li theem plaub, pristanal tau oxidation los ntawm aldehyde dehydrogenase, tsim pristanic acid.
Beta Oxidation yog dab tsi?
Beta oxidation yog txheej txheem catabolic uas fatty acid molecules tawg hauv cytosol ntawm prokaryotes thiab hauv mitochondria hauv eukaryotes tsim acetyl CoA, NADH, thiab FADH2. Qhov no acetyl CoA yuav nkag mus rau lub voj voog citric acid. NADH thiab FADH2 uas tsim tawm ntawm no ua cov co-enzymes uas muaj txiaj ntsig zoo hauv cov saw hlau thauj hluav taws xob.
Daim duab 02: Mitochondrial Fatty Acid Beta Oxidation Process
Beta oxidation yog lub npe xws li vim yog beta carbon ntawm fatty acid uas dhau oxidation los ua ib pawg carbonyl. Tsis tas li ntawd, cov txheej txheem no feem ntau yog txhawb nqa los ntawm mitochondrial trifunctional protein (nws yog ib qho enzyme uas cuam tshuam nrog cov mitochondrial membrane).
Qhov txawv ntawm Alpha thiab Beta Oxidation yog dab tsi?
Alpha oxidation yog ib qho txheej txheem uas qee cov roj fatty acids tau tawg los ntawm kev tshem tawm ib qho carbon ntawm carboxyl kawg ntawm cov molecule. Beta oxidation yog txheej txheem catabolic uas fatty acid molecules tawg hauv cytosol ntawm prokaryotes thiab hauv mitochondria hauv eukaryotes tsim acetyl CoA, NADH, thiab FADH2. Qhov sib txawv tseem ceeb ntawm alpha thiab beta oxidation yog tias alpha oxidation feem ntau tshwm sim nyob rau hauv lub hlwb thiab daim siab uas ib tug carbon atom poob nyob rau hauv daim ntawv ntawm ib tug carbon dioxide molecule, whereas beta oxidation txheej txheem tsuas yog nyob rau hauv lub mitochondria matrix qhov twg ob-carbon. units raug tso tawm raws li acetyl CoA ib lub voj voog.
Hauv qab no yog cov ntsiab lus ntawm qhov sib txawv ntawm alpha thiab beta oxidation hauv daim ntawv tabular rau ib sab ntawm kev sib piv.
Summary – Alpha vs Beta Oxidation
Alpha thiab beta oxidation yog cov txheej txheem biochemical tseem ceeb. Qhov sib txawv tseem ceeb ntawm alpha thiab beta oxidation yog alpha oxidation feem ntau tshwm sim nyob rau hauv lub hlwb thiab daim siab, qhov twg ib tug carbon atom poob nyob rau hauv daim ntawv ntawm ib tug carbon dioxide molecule, whereas beta oxidation feem ntau tshwm sim nyob rau hauv lub mitochondria matrix qhov twg ob-carbon. units raug tso tawm raws li acetyl CoA ib lub voj voog.
