Qhov sib txawv tseem ceeb ntawm calbindin calretinin thiab calmodulin yog calbindin yog cov protein uas koom nrog calcium khi thiab nqus tau, thaum calretinin yog cov protein koom nrog hauv kev qhia calcium, thaum calmodulin yog cov protein uas ua haujlwm raws li kev sib txuas ntawm cov calcium uas nyob nruab nrab. tus tub txib.
Calcium homeostasis yog txheej txheem tseem ceeb hauv lub cev noj qab haus huv. Nws ua tiav los ntawm kev tswj hwm ntawm calcium nqus thiab tshem tawm cov calcium ntau dhau. Calcium homeostasis yog tswj los ntawm plab hnyuv calcium nqus, tso zis calcium, thiab tsim cov pob txha. Calbindin, calretinin, thiab calmodulin yog peb cov proteins tseem ceeb los tswj cov calcium homeostasis.
Calbindin yog dab tsi?
Calbindin yog vitamin D teb calcium-binding protein koom nrog hauv kev nqus calcium. Calbindin nyob ntawm vitamin D rau kev nqus calcium. Nws tau pom thawj zaug hauv cov hnyuv ntawm cov noog, thiab tom qab ntawd nws tau pom hauv cov tsiaj nyeg. Tshwj xeeb hauv cov tsiaj, nws muaj nyob rau hauv lub raum. Lwm yam tshaj li lub raum, calbindin muaj nyob rau hauv ob qho tib si neuronal thiab endocrine hlwb.
Daim duab 01: Calbindin
Calbindin protein yog encoded los ntawm cov noob CALB1. Calbindin muaj 4 lub luag haujlwm calcium-binding domains nrog 2 hloov chaw. Cov chaw hloov kho tsis muaj peev xwm rau calcium-binding. Calbindin kuj ua raws li calcium tsis. Ib zaug, calbindin tuaj yeem tuav 4 Ca2+ hauv cov qauv calbindin, uas yog hu ua EF-tes ntawm loops. EF-tes ntawm lub voj voog yog lub helix structural domain. Calbindin muaj 4 EF-tes ntawm loops.
Calretinin yog dab tsi?
Calretinin yog calcium-binding protein koom nrog hauv calcium signaling rau cov txheej txheem calcium binding. Calretinin protein yog encoded los ntawm cov noob CALB2. Calretinin muaj rau EF-tes ntawm lub voj. Calretinin ua tiav ntau lub zog ntawm tes, suav nrog cov calcium buffering intracellular thiab cov lus qhia. Tsis zoo li calbindin, calretinin tsis nyob ntawm cov vitamin D. Calretinin feem ntau muaj nyob rau hauv cov neurons (feem ntau nyob rau hauv lub retina) thiab cortical interneurons.
Daim duab 02: Calretinin
Calretinin ua lub luag haujlwm tseem ceeb hauv kev hloov pauv ntawm neuronal excitability, tshwj xeeb tshaj yog nyob rau hauv induction ntawm lub sij hawm ntev potentiation. Kev poob ntawm kev qhia ntawm calretinin hauv hippocampal interneurons ua rau lub cev tsis muaj zog ntawm lub cev. Calretinin kuj muaj nyob rau hauv cov hauv paus plaub hau. Qhov tseem ceeb ntawm kev kho mob ntawm calretinin yog tias nws yog siv los ua cov cim kev kuaj mob rau ntau cov qog nqaij hlav thiab kab mob Hirschsprung.
Calmodulin yog dab tsi?
Calmodulin yog ib qho kev hloov pauv protein uas koom nrog hauv cov txheej txheem calcium-binding. Nws yog ib tug multifunctional intermediate calcium-binding tub txib tam sim no nyob rau hauv tag nrho cov eukaryotic hlwb. Kev ua kom muaj zog ntawm calmodulin tsuas yog tshwm sim hauv cov lus teb rau kev khi ntawm Ca2+ Thaum khi thiab ua kom muaj zog ntawm calmodulin, nws ua ib feem ntawm calcium signaling transduction pathway.
Daim duab 03: Calmodulin
Calmodulin hloov kho nws cov kev cuam tshuam nrog ntau lub hom phiaj proteins. Cov proteins no suav nrog phosphatase thiab kinases. Calmodulin muaj 148 amino acids; yog li nws yog ib qho me me tab sis muaj kev txuag protein ntau. Tsis zoo li calbindin thiab calretinin, calmodulin muaj ob kwv yees li symmetrical globular domains; txhua tus sau muaj ib khub ntawm EF-tes motifs. Calmodulin muaj qib siab ntawm cov qauv yooj yim txij li nws tsom mus rau ntau hom phiaj proteins.
Dab tsi yog qhov zoo sib xws ntawm Calbindin Calretinin thiab Calmodulin?
- Calbindin, calretinin, thiab calmodulin yog cov proteins.
- Txhua peb qhov tseem ceeb hauv calcium metabolism.
- Ntxiv mus, tag nrho peb cov proteins muaj Ef tes ntawm lub voj.
- Lawv yog tsim los ntawm helical proteins.
- Lawv muaj nyob rau hauv cov tsiaj.
- Txhua peb hom yog qhov tseem ceeb hauv kev tswj cov calcium-binding thiab nqus.
Qhov txawv ntawm Calbindin Calretinin thiab Calmodulin yog dab tsi?
Calbindin yog cov protein koom nrog hauv calcium-binding thiab nqus tau, thaum calretinin yog cov protein koom nrog hauv calcium signaling thiab calmodulin yog cov protein uas ua haujlwm raws li kev sib txuas lus sib txuas ntawm calcium-binding messenger. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm calbindin calretinin thiab calmodulin. Cov noob uas koom nrog hauv coding calbindin, calretinin, thiab calmodulin yog CALB1, CALB2, thiab CALM1, 2, 3, feem. Thaum calbindin yog ncaj qha nyob ntawm cov vitamin D, calretinin yog ywj siab ntawm vitamin D. Txawm li cas los xij, lub luag hauj lwm ntawm vitamin D nyob ntawm calmodulin tseem tsis tau pom.
Cov hauv qab no qhia txog qhov sib txawv ntawm calbindin calretinin thiab calmodulin hauv daim ntawv qhia rau ib sab ntawm kev sib piv.
Summary – Calbindin vs Calretinin vs Calmodulin
Calbindin, calretinin, thiab calmodulin yog peb cov proteins koom nrog hauv calcium homeostasis. Calbindin yog qhov tseem ceeb hauv calcium binding thiab nqus tau, thaum calretinin yog qhov tseem ceeb hauv calcium signaling thaum calcium binding, thiab calmodulin ua haujlwm raws li cov khoom siv ntau yam intermediate calcium-binding messenger protein. Cov noob uas koom nrog hauv coding calbindin, calretinin, thiab calmodulin yog CALB1, CALB2, thiab CALM1, 2, 3, feem. Yog li, qhov no qhia txog qhov sib txawv ntawm calbindin calretinin thiab calmodulin.
