Qhov sib txawv tseem ceeb ntawm SGOT thiab SGPT yog tias SGOT ua rau kev hloov pauv ntawm α-amino pawg los ntawm L-aspartate rau α-ketoglutarate thiaj li tsim oxaloacetate thiab L-glutamate thaum SGPT catalyzes hloov ntawm α- amino pawg los ntawm L-alanine rau α-ketoglutarate los tsim pyruvate thiab L-glutamate.
SGOT qib thiab SGPT qib thiab lawv qhov piv (SGOT / SGPT) feem ntau ntsuas raws li biomarkers hauv kev kho mob rau daim siab mob. Cov kev ntsuam xyuas no yog ib feem ntawm cov hlab ntshav. Ntxiv mus, cov kev ntsuam xyuas no feem ntau hu ua kev kuaj lub siab ua haujlwm. Yog li, SGOT qib thiab SGPT qib thiab lawv qhov piv (SGOT / SGPT) yog cov txiaj ntsig biomarkers ntawm daim siab raug mob hauv tus neeg mob uas muaj qee qhov kev ua haujlwm ntawm lub siab tsis zoo.
Dab tsi yog SGOT (Serum Glutamic Oxaloacetic Transaminase)?
Serum glutamic oxaloacetic transaminase (SGOT) yog ib qho enzyme uas catalyzes interconversion ntawm aspartate thiab α-ketoglutarate rau oxaloacetate thiab glutamate. Nws tseem hu ua aspartate transaminase (AST). Cov enzyme no yog pyridoxal phosphate (PLP) nyob ntawm transaminase enzyme. SGOT tau pom thawj zaug los ntawm Arthur Karmen thiab cov npoj yaig hauv xyoo 1954. Tsis tas li ntawd, qhov enzyme no catalyzes hloov pauv ntawm α-amino pawg los ntawm L-aspartate mus rau α-ketoglutarate thiaj li tsim oxaloacetate thiab L-glutamate. Yog li ntawd, nws yog ib qho tseem ceeb heev enzyme nyob rau hauv cov amino acid metabolism. SGOT feem ntau pom muaj nyob hauv daim siab, lub plawv, cov leeg pob txha, ob lub raum, lub hlwb, cov qe ntshav liab, thiab lub zais zis. Qib SGOT thiab SGPT qib thiab lawv qhov piv (SGOT/SGPT) feem ntau ntsuas raws li biomarkers rau daim siab mob.
Daim duab 01: SGOT
Lub neej ib nrab ntawm tag nrho SGOT hauv kev ncig yog kwv yees li ntawm 17 teev. Qhov nruab nrab 87 teev rau mitochondrial SGOT. Tsis tas li ntawd, SGOT raug tshem tawm los ntawm cov hlwb sinusoidal hauv daim siab. Muaj ob SGOT isoenzymes tam sim no nyob rau hauv ntau yam eukaryotes. Hauv tib neeg, lawv yog GOT1 / cAST (cytosolic isoenzyme feem ntau yog los ntawm cov qe ntshav liab thiab lub plawv) thiab GOT2 / mAST (lub mitochondrial isoenzyme uas tam sim no feem ntau hauv daim siab). Clinically elevated SGOT theem tuaj yeem pom hauv cov kab mob xws li myocardial infarction, mob pancreatitis, mob haemolytic anemia, kub hnyiab, mob raum mob, kab mob musculoskeletal, thiab raug mob. Tsis tas li ntawd, SGOT / SGPT piv ntau dua 2 yog qhia txog kev haus dej cawv kab mob siab thiab cirrhosis.
SGPT (Serum Glutamic Pyruvic Transaminase) yog dab tsi?
Serum glutamic pyruvic transaminase (SGPT) yog ib qho enzyme uas ua rau kev hloov pauv ntawm α-amino pawg los ntawm L-alanine mus rau α-ketoglutarate los tsim pyruvate thiab L-glutamate. Nws tseem hu ua alanine aminotransferase (ALT). SGPT yog thawj tus yam ntxwv hauv xyoo 1950 los ntawm Arthur Karmen thiab cov npoj yaig. SGPT muaj nyob rau hauv plasma thiab nyob rau hauv ntau yam ntaub so ntswg ntawm lub cev. Tab sis feem ntau, nws pom nyob rau hauv daim siab.
Daim duab 02: SGPT
Ib nrab-lub neej ntawm SGPT hauv kev ncig yog kwv yees li ntawm 47 teev. SGPT raug tshem tawm los ntawm cov hlwb sinusoidal hauv daim siab. SGPT kuj xav tau cov coenzyme pyridoxal phosphate, uas hloov mus rau pyridoxamine thaum lub sij hawm hloov pauv hloov pauv. Tsis tas li ntawd, qhov nce qib ntawm "Duab" feem ntau qhia txog kev muaj mob xws li kab mob siab kab mob siab, ntshav qab zib, mob plawv tsis ua haujlwm, lub siab puas, teeb meem kab mob hauv lub cev, kab mob mononucleosis, thiab myopathy. alt="
Dab tsi yog qhov zoo sib xws ntawm SGOT thiab SGPT?
- SGOT qib thiab SGPT qib thiab lawv qhov piv (SGOT / SGPT) yog cov txiaj ntsig biomarkers ntawm daim siab raug mob hauv tus neeg mob uas muaj qee qhov kev ua haujlwm ntawm lub siab tsis zoo.
- Ob lub enzymes yog cov proteins ua los ntawm cov amino acids.
- Cov enzymes no muaj qhov tseem ceeb hauv kev kuaj mob.
- Ob lub enzymes xav tau pyridoxal phosphate (PLP) ua coenzyme.
- Cov enzymes no yog thawj zaug pom los ntawm Arthur Karmen thiab cov npoj yaig.
- Lawv catalyze reversible transamination cov tshuaj tiv thaiv.
Qhov txawv ntawm SGOT thiab SGPT yog dab tsi?
SGOT catalyzes kev hloov ntawm ib pawg α-amino los ntawm L-aspartate rau α-ketoglutarate thiaj li tsim oxaloacetate thiab L-glutamate thaum SGPT catalyzes kev hloov ntawm ib pawg α-amino los ntawm L-alanine rau α- ketoglutarate los tsim pyruvate thiab L-glutamate. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm SGOT thiab SGPT.
Cov hauv qab no infographic nthuav tawm qhov sib txawv ntawm SGOT thiab SGPT hauv daim ntawv teev npe rau ib sab ntawm kev sib piv.
Summary – SGOT vs SGPT
SGOT thiab SGPT yog cov txiaj ntsig biomarkers ntawm daim siab raug mob hauv tus neeg mob uas muaj qee qhov kev ua haujlwm ntawm lub siab tsis zoo. Lawv muaj qhov tseem ceeb hauv kev kuaj xyuas lwm yam kab mob thiab. SGOT catalyzes kev hloov ntawm ib pawg α-amino los ntawm L-aspartate rau α-ketoglutarate thiaj li yuav tsim oxaloacetate thiab L-glutamate thaum SGPT catalyzes hloov ntawm ib pawg α-amino los ntawm L-alanine mus rau α-ketoglutarate los tsim pyruvate thiab L-glutamate. Yog li, qhov no qhia txog qhov sib txawv ntawm SGOT thiab SGPT.
