Qhov sib txawv tseem ceeb ntawm NRF1 thiab NRF2 yog lawv txoj haujlwm. NRF1 yog ib qho kev hloov pauv uas ua rau muaj kev nthuav qhia ntawm qee qhov tseem ceeb hauv cov noob caj noob ces tswj kev loj hlob ntawm cellular thiab cov noob nuclear xav tau rau kev ua pa, heme biosynthesis, mitochondrial DNA transcription, thiab rov ua dua, thaum NRF2 yog ib qho kev hloov pauv uas tswj cov kev qhia ntawm cov noob caj noob ces uas tiv thaiv. tiv thaiv oxidative puas tsuaj tshwm sim los ntawm kev raug mob thiab o.
Cov ntsiab lus hloov pauv yog cov protein molecules koom nrog hauv kev tswj hwm tus nqi ntawm cov ntaub ntawv caj ces ntawm DNA mus rau tus xa xov RNA (mRNA). Yog li ntawd, lub luag haujlwm tseem ceeb ntawm kev hloov pauv cov ntsiab lus yog tswj hwm kev hloov pauv ntawm thiab tawm ntawm cov noob txhawm rau txhawm rau kom paub tseeb tias cov noob tau nthuav tawm kom raug raws sijhawm nyob rau hauv lub neej voj voog ntawm lub cev. NRF1 thiab NRF2 yog ob yam tseem ceeb ntawm tib neeg kev hloov pauv uas tswj kev qhia ntawm cov noob tseem ceeb.
NRF1 (Nuclear Respiratory Factor 1) yog dab tsi?
Nuclear respiratory factor 1 (NRF1) yog ib qho kev hloov pauv uas ua rau muaj kev qhia txog qee yam tseem ceeb hauv cov noob caj noob ces, tswj cov cellular loj hlob thiab cov noob nuclear xav tau rau kev ua pa, heme biosynthesis, mitochondrial DNA transcription, thiab replication. NRF1, ua ke nrog NRF2, kho cov genomic kev sib koom tes ntawm nuclear thiab mitochondrial noob. Qhov no yog ua los ntawm ncaj qha tswj qhov kev qhia ntawm ntau lub nuclear-encoded ETC proteins thiab indirectly tswj peb mitochondrial-encoded noob los ntawm activating mtTFA, mtTFB1, thiab mtTFB2.
Figure 01: NRF1
Nws tseem hu ua NRF-1. Tsis tas li ntawd, cov protein no kuj tau txuam nrog kev tswj hwm ntawm neurite outgrowth. Neurite yog hais txog txhua qhov projection los ntawm lub cev hlwb xws li axon thiab dendrite. Tsis tas li ntawd, cyclinD1 nyob ntawm kinase tswj kev sib koom tes ntawm cov DNA DNA synthesis thiab mitochondrial muaj nuj nqi los ntawm phosphorylating NRF1 ntawm S47 txoj haujlwm. Ntxiv rau qhov ntawd, NRFI kuj tau pom tias muaj kev cuam tshuam nrog lwm cov proteins tseem ceeb xws li DYNLL1, PPARGCIA, thiab PPRC1.
NRF2 yog dab tsi (Factor Erythroid 2-Related Factor 2)?
Nuclear factor erythroid 2-related factor 2 (NRF2) yog ib qho kev hloov pauv uas tswj cov kev qhia ntawm cov noob caj noob ces, uas tiv thaiv oxidative puas tsuaj los ntawm kev raug mob thiab mob. Nws yog encoded los ntawm NFE2L2 noob nyob rau hauv tib neeg. Nyob rau hauv vitro tej yam kev mob, NRF2 khi rau antioxidant teb ntsiab lus (AREs) nyob rau hauv lub nucleus, ua rau transcription ntawm ARE noob. NRF2 kuj nce heme oxygenase 1 hauv vitro mob koom nrog hauv cov txheej txheem kho. Ntxiv mus, NRF2 kuj inhibits NLRP3 inflammasome uas induces inflammatory teb.
Figure 02: NRF2
Tsis tas li ntawd, NRF2 koom nrog txoj hauv kev tswj hwm txoj hauv kev thiab ua haujlwm pleitropic hauv kev tswj cov metabolism, mob, autophagy, proteostasis, mitochondrial physiology, thiab kev tiv thaiv kab mob. Ntau cov tshuaj txhawb txoj hauv kev NRF2. Cov tshuaj no tau kawm rau kev kho mob ntawm cov kab mob uas tshwm sim los ntawm oxidative kev nyuaj siab. Piv txwv ntawm cov tshuaj uas ua rau txoj kev NRF2 muaj xws li dimethyl fumarate thiab dithiolethiones. Dimethyl fumarate yog ib qho tshuaj siv los kho ntau yam sclerosis. Dithiolethiones inhibit tsim cov qog nqaij hlav hauv cov kab mob nas, nrog rau lub zais zis, ntshav, plab hnyuv, raum, siab, ntsws, pancreas, plab, trachea, tawv nqaij, thiab cov ntaub so ntswg mammary. Txawm li cas los xij, dithiolethiones tsis raug pom zoo rau tib neeg siv vim muaj tshuaj lom xws li neurotoxicity thiab gastrointestinal toxicity.
NRF1 thiab NRF2 yog dab tsi?
- NRF1 thiab NRF2 yog ob yam tseem ceeb ntawm tib neeg kev hloov pauv uas tswj kev qhia ntawm cov noob tseem ceeb.
- NRF1, ua ke nrog NRF2, kho kom haum xeeb ntawm kev sib koom tes ntawm genomic ntawm nuclear thiab mitochondrial noob.
- ob leeg yog cov protein.
- Lawv txoj haujlwm tseem ceeb heev rau kev ciaj sia ntawm tib neeg.
Qhov txawv ntawm NRF1 thiab NRF2 yog dab tsi?
NRF1 yog ib qho kev hloov pauv uas ua rau muaj kev qhia txog qee yam tseem ceeb hauv cov noob caj noob ces, uas tswj kev loj hlob ntawm tes thiab cov noob caj noob ces xav tau rau kev ua pa, heme biosynthesis, mitochondrial DNA transcription, thiab rov ua dua, thaum NRF2 yog ib qho kev hloov pauv uas tswj cov kev ua pa. qhia txog cov noob caj noob ces antioxidant, uas tiv thaiv oxidative puas tsuaj tshwm sim los ntawm kev raug mob thiab o. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm NRF1 thiab NRF2. Tsis tas li ntawd, NRF1 yog encoded los ntawm NRF1 noob, thaum NRF2 yog encoded los ntawm NFE2L2 noob.
Cov hauv qab no infographic nthuav tawm qhov sib txawv ntawm NRF1 thiab NRF2 hauv daim ntawv teev npe rau ib sab ntawm kev sib piv.
Summary – NRF1 vs NRF2
NRF1 thiab NRF2 yog ob qho tib si hloov pauv tib neeg. NRF1 yog ib qho kev hloov pauv uas ua rau kev nthuav tawm ntawm qee qhov tseem ceeb hauv cov noob caj noob ces tswj kev loj hlob ntawm cellular thiab cov noob nuclei xav tau rau kev ua pa, heme biosynthesis, mitochondrial DNA transcription, thiab replication thaum NRF2 yog ib qho kev hloov pauv uas tswj cov kev qhia ntawm cov noob caj noob ces, uas tiv thaiv. oxidative kev puas tsuaj tshwm sim los ntawm kev raug mob thiab o. Yog li, qhov no qhia txog qhov sib txawv ntawm NRF1 thiab NRF2.
