Qhov sib txawv tseem ceeb ntawm alpha thiab beta galactosidase yog tias alpha galactosidase yog ib qho enzyme uas yog lub luag haujlwm rau kev rhuav tshem cov substrates uas muaj cov alpha galactosidic residues xws li glycosphingolipids lossis glycoproteins, thaum beta-galactosidase yog ib qho enzyme uas yog lub luag haujlwm rau kev tawg. nqes cov beta galactosides xws li disaccharide lactose rau hauv nws cov monosaccharide Cheebtsam, qabzib thiab galactose.
Galactosidases yog cov enzymes uas catalyze hydrolysis ntawm galactosides rau hauv monosaccharides. Lawv kuj hu ua glycoside hydrolases. Galactosidases muaj ntau yam kev siv, suav nrog kev tsim cov prebiotics, tshem tawm lactose thiab biosynthesis ntawm transgalactosylated khoom. Galactosidases tuaj yeem faib ua ob hom: alpha thiab beta-galactosidase.
Alpha Galactosidase yog dab tsi?
Alpha galactosidase yog ib qho enzyme uas yog lub luag haujlwm rau kev rhuav tshem cov substrates uas muaj alpha galactosidic residues xws li glycosphingolipids lossis glycoproteins. Nws yog glycoside hydrolase enzyme uas hydrolyses lub davhlau ya nyob twg alpha galactosyl moieties los ntawm glycolipids thiab glycoproteins. Tsis tas li ntawd, nws tshem tawm glycoproteins, glycolipids, thiab polysaccharides. Qhov no enzyme tshwj xeeb catalyzes tshem tawm ntawm lub davhlau ya nyob twg alpha galactose los ntawm oligosaccharides. Alpha galactosidase yog encoded los ntawm GLA gene.
Daim duab 01: Alpha Galactosidase
Ob daim ntawv rov ua dua ntawm alpha-galactosidase yog agalsidase alpha (INN) thiab agalsidase beta (INN). Beano yog ib qho ntxiv uas pab tau rau hauv plab plab, plab plab, mob plab, thiab plab plab. Cov khoom xyaw tseem ceeb hauv Beano yog cov pwm tsim los ntawm ntuj alpha galactosidase. Cov tshuaj no yog noj ua ntej noj zaub mov uas feem ntau ua rau cov tsos mob no. Beano zom thiab zom cov carbohydrates yooj yim xws li cov zaub hauv cov zaub, suav nrog zaub paj, zaub qhwv, Brussels sprouts, thiab zaub qhwv. Cov tshuaj no tuaj yeem zom cov carbohydrates hauv legumes, suav nrog lentils, taum, txiv ntoo. Txawm li cas los xij, cov tshuaj no tsis zoo rau kev tiv thaiv roj los ntawm kev nyuaj hauv kev zom cov lactose lossis fiber ntau. Ntxiv mus, qhov tsis xws luag hauv tib neeg alpha galactosidase ua rau Fabry kab mob. Tus kab mob no yog ib qho tsis tshua muaj lysosomal storage disorder thiab sphingolipidosis. Qhov mob no yog tshwm sim los ntawm qhov ua tsis tiav rau catabolize alpha D galactosyl glycolipid moieties.
YBeta Galactosidase yog dab tsi?
Beta galactosidase yog ib qho enzyme uas yog lub luag haujlwm rau kev rhuav tshem cov beta galactosides xws li disaccharide lactose rau hauv nws cov khoom monosaccharide - qabzib thiab galactose. Nws kuj tseem yog glycoside hydrolase enzyme uas catalyzes hydrolysis ntawm beta galactosides rau hauv monosaccharides ntawm kev rhuav tshem ntawm glycosidic daim ntawv cog lus. Beta galactosides yog cov carbohydrates uas muaj galactose qhov twg glycosidic daim ntawv cog lus nyob saum cov galactose molecule. Ganglioside GM1, lactosylceramides, lactose, thiab lwm yam, yog substrates rau txawv beta galactosidases.
Daim duab 02: Beta Galactosidase
Beta galactosidase yog encoded los ntawm GLB1 noob hauv tib neeg. Hauv E.coli lacZ gene yog cov qauv tsim rau beta galactosidase. Qhov tsis txaus ntawm beta galactosidase ua rau ob yam kab mob metabolic cia: GM1 gangliosidosis (GM1) thiab Morquio B kab mob. Cov no yog cov kab mob autosomal uas tau tshwm sim. Tsis tas li ntawd, cov enzyme no feem ntau yog siv hauv kev tshuaj ntsuam genetic thiab molecular biology ua tus neeg sau xov xwm los soj ntsuam cov noob qhia (xiav-dawb tshuaj ntsuam).
Dab tsi zoo sib xws ntawm Alpha thiab Beta Galactosidase?
- Alpha thiab beta galactosidase yog ob hom galactosidases.
- YLawv yog glycoside hydrolases.
- YLawv yog cov proteins uas muaj cov khoom muaj zog.
- ob leeg yog tsim los ntawm cov amino acids.
- Ob lub enzymes catalyze hydrolysis ntawm galactosides rau hauv monosaccharides.
Qhov txawv ntawm Alpha thiab Beta Galactosidase yog dab tsi?
Alpha galactosidase yog ib qho enzyme uas yog lub luag haujlwm rau kev rhuav tshem cov substrates uas muaj alpha galactosidic residues, thaum beta galactosidase yog ib qho enzyme uas yog lub luag haujlwm rau rhuav tshem cov beta galactosides. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm alpha thiab beta galactosidase. Tsis tas li ntawd, alpha galactosidase yog encoded los ntawm GLA noob hauv tib neeg thaum beta galactosidase yog encoded los ntawm GLB1 noob hauv tib neeg.
Cov infographic hauv qab no qhia ntau qhov sib txawv ntawm alpha thiab beta galactosidase hauv daim ntawv tabular rau ib sab ntawm kev sib piv.
Summary – Alpha vs Beta Galactosidase
Galactosidases yog glycoside hydrolases uas ua rau lub hydrolysis ntawm galactosides rau hauv monosaccharides. Alpha thiab beta galactosidase yog ob hom galactosidases. Alpha galactosidase rhuav tshem cov substrates uas muaj alpha galactosidic residues thaum beta galactosidase rhuav tshem beta galactosides xws li disaccharide lactose rau hauv nws cov khoom monosaccharide. Yog li, qhov no yog cov ntsiab lus ntawm qhov sib txawv ntawm alpha thiab beta galactosidase.
