Qhov sib txawv tseem ceeb ntawm cov hlab ntsha thiab cov hlab ntsha hauv cov hlab ntsha ntxiv yog tias hauv cov hlab ntshav hemolysis, kev puas tsuaj ntawm cov qe ntshav liab hauv cov hlab ntsha tshwm sim, thaum nyob rau hauv extravascular hemolysis, kev puas tsuaj ntawm cov qe ntshav liab nyob rau lwm qhov hauv lub cev, feem ntau hauv Lub siab, tus po, pob txha pob txha, thiab cov qog nqaij hlav vim yog cov macrophages.
cov qe ntshav liab lossis erythrocytes yog cov cellular tseem ceeb hauv cov ntshav uas nqa oxygen los ntawm lub ntsws mus rau cov ntaub so ntswg. Lub neej ib txwm muaj ntawm cov qe ntshav liab yog 120 hnub. Anemia yog ib yam mob uas hais txog qhov tsis txaus ntawm cov qe ntshav liab noj qab nyob zoo hauv cov ntshav kom nqa oxygen mus rau hauv cov ntaub so ntswg hauv lub cev. Hauv lwm lo lus, nws yog qhov xwm txheej ntawm cov qe ntshav liab qis hauv cov ntshav. Thaum muaj mob anemic, ntshav tsis tuaj yeem nqa oxygen txaus rau cov ntaub so ntswg. Anemia tuaj yeem tshwm sim feem ntau yog vim muaj cov qe ntshav liab tsis zoo, kev puas tsuaj ntawm cov qe ntshav liab txawv txav, kua dej ntau dhau thiab poob ntshav. Hemolysis yog hais txog kev puas tsuaj ntawm cov qe ntshav liab, tso hemoglobin mus rau qhov nruab nrab ib puag ncig. Hemolytic anemia yog ib hom kab mob ntshav liab uas tshwm sim los ntawm kev puas tsuaj ntawm cov qe ntshav liab. Nws tuaj yeem tshwm sim hauv ob txoj hauv kev ua intravascular lossis extravascular.
Dab tsi yog Intravascular Hemolysis?
Intravascular hemolysis yog ib qho ntawm ob hom hemolysis hauv hemolytic anemia. Cov qe ntshav liab hauv cov hlab ntsha raug rhuav tshem hauv intravascular hemolysis. Qhov no ua rau kev tso tawm ntawm hemoglobin rau hauv cov ntshav, ua rau hemoglobinuria. Nws tseem yog lub luag haujlwm rau qhov tshwm sim ntawm hemoglobinemia. Intravascular hemolysis tuaj yeem tshwm sim vim muaj qhov tsis xws ntawm enzyme thiab qee yam kev tiv thaiv kab mob. Autoantibodies tuaj yeem tsom cov qe ntshav liab thiab rhuav tshem lawv. Ntxiv mus, qee cov kab mob tuaj yeem ua rau cov qe ntshav liab.
Daim duab 01: Hemolytic Anemia
Dab tsi yog Extravascular Hemolysis?
Extravascular hemolysis yog thib ob txheej txheem ntawm hemolysis uas ua rau hemolytic anemia. Nyob rau hauv extravascular hemolysis, ntshav liab kev puas tsuaj tshwm sim nyob rau hauv lub siab, spleen, pob txha pob txha, thiab lymph nodes. Yog li ntawd, hemoglobin khiav mus rau hauv cov ntshav plasma.
Daim duab 02: Extravascular Hemolysis
Nyob rau hauv cov txheej txheem no, macrophages hauv cov kab ke reticuloendothelial kuaj pom cov qe ntshav liab tsis zoo, nteg thiab rhuav tshem lawv. Spleen rhuav tshem cov qe ntshav liab me me thaum lub siab ua kom cov qe ntshav liab tsis zoo, uas yog coated los ntawm cov tshuaj tiv thaiv. Yog li ntawd, extravascular hemolysis feem ntau yog tsav los ntawm tus po thiab daim siab kom tshem tawm cov RBCs puas lossis txawv txav los ntawm kev ncig.
Dab tsi zoo sib xws ntawm Intravascular thiab Extravascular Hemolysis?
- Intravascular thiab extravascular hemolysis yog ob hom kev ua haujlwm ntawm hemolysis hauv hemolytic anemia.
- Nyob rau hauv ob qho xwm txheej, hemoglobin khiav mus rau hauv cov ntshav plasma vim kev puas tsuaj ntawm cov qe ntshav liab.
- Vim ob qho xwm txheej, lub peev xwm ntawm cov ntshav nqa oxygen mus rau hauv cov ntaub so ntswg hauv lub cev txo qis.
- Ob leeg tuaj yeem tshwm sim vim muaj cov txheej txheem tiv thaiv kab mob.
Qhov txawv ntawm Intravascular thiab Extravascular Hemolysis yog dab tsi?
Intravascular hemolysis yog ib hom hemolysis uas qhov kev puas tsuaj ntawm cov qe ntshav liab hauv cov hlab ntsha tshwm sim. Nyob rau hauv sib piv, extravascular hemolysis yog ib hom hemolysis nyob rau hauv uas kev puas tsuaj ntawm cov qe ntshav liab nyob rau hauv daim siab, spleen, pob txha pob txha, thiab lymph nodes tshwm sim los ntawm macrophages. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm intravascular thiab extravascular hemolysis. Tsis tas li ntawd, intravascular hemolysis tshwm sim vim muaj qhov tsis zoo ntawm enzyme thiab qee yam kev tiv thaiv kab mob hauv lub cev thaum lub sij hawm extravascular hemolysis tshwm sim thaum cov qe ntshav liab tsis raug cuam tshuam thiab rhuav tshem los ntawm cov macrophages.
Cov lus hauv qab no qhia txog qhov sib txawv ntawm cov hlab ntsha thiab cov hlab ntsha hauv cov hlab ntsha hauv cov hlab ntsha.
Summary – Intravascular vs Extravascular Hemolysis
Intravascular thiab extravascular hemolysis yog ob txoj hauv kev uas hemolysis tshwm sim. Cov qe ntshav liab hauv cov hlab ntsha raug rhuav tshem hauv intravascular hemolysis. Cov qe ntshav liab nyob rau lwm qhov hauv lub cev, xws li daim siab, spleen, pob txha pob txha, thiab lwm yam, raug rhuav tshem hauv cov hlab ntshav hemolysis. Pleev thiab daim siab tshem tawm cov qe ntshav liab uas puas lawm los ntawm kev ncig los ntawm cov hlab ntshav hemolysis. Intravascular hemolysis tshwm sim vim tsis muaj enzymes, co toxins, txheej txheem autoimmune, raug mob, thiab lwm yam. Yog li, qhov no yog cov ntsiab lus ntawm qhov sib txawv ntawm intravascular thiab extravascular hemolysis.
