Qhov sib txawv tseem ceeb ntawm cadherin thiab integrin yog cadherin yog lub cell adhesion molecule uas yog qhov tseem ceeb hauv cell rau cell adhesion, hos integrin yog cell adhesion molecule uas tseem ceeb hauv cell rau extracellular matrix adhesion.
Cell adhesion molecules yog cov proteins nyob rau ntawm lub cell. Lawv koom nrog hauv kev khi cov hlwb nrog lwm cov hlwb lossis nrog cov matrix extracellular. Cell adhesion yog ib qho tseem ceeb heev hauv kev tswj cov ntaub so ntswg thiab kev ua haujlwm. Cov molecules no pab tuav cov tsiaj cell ua ke. Sib nrug los ntawm kev ua cov kua nplaum molecular, cell adhesion molecules tseem pab hauv kev loj hlob ntawm tes, tiv thaiv kev tiv thaiv, thiab apoptosis. Qee zaum, qhov tsis txaus ntseeg ntawm cov cell adhesion molecules ua rau pathologies xws li frostbite thiab mob qog noj ntshav. Yog li ntawd, cadherin thiab integrin yog ob hom calcium-dependent cell adhesion molecules.
Cadherin yog dab tsi?
Cadherin yog lub cell adhesion molecule uas yog qhov tseem ceeb hauv cell-rau-cell adhesion. Nws tseem yog ib qho tseem ceeb heev nyob rau hauv tsim ntawm adherens junctions. Cadherin yog ib chav kawm ntawm hom I transmembrane proteins. Calcium ions tseem ceeb heev rau kev ua haujlwm ntawm cadherin. Lub cell rau cell adhesion yog kho los ntawm extracellular cadherin domains thaum lub intracellular cytoplasmic tail yog txuam nrog cadherin adhesome. Cov tswv cuab ntawm tsev neeg cadherin yog qhov tseem ceeb rau kev tswj cov xov tooj ntawm tes rau kev sib cuag ntawm tes thiab tseem tswj hwm cytoskeletal complexes. Lub cadherin superfamily muaj xws li protocadherins, desmogleins, thiab desmocollins, thiab lwm yam. Lawv tag nrho qhia cov cadherin rov, uas yog cov extracellular calcium-binding domains.
Daim duab 01: Cadherin
Cadherin coj li ob qho tib si receptor thiab ligand rau lwm cov molecules. Nws pab txoj kev muab cov hlwb kom zoo thaum lub sij hawm kev loj hlob. Nws kuj pab kev sib cais ntawm cov txheej txheem sib txawv ntawm cov ntaub so ntswg thiab cellular migration. Tsis tas li ntawd, E-cadherins yog qhov tseem ceeb hauv ntau cov txheej txheem ntawm embryogenesis, xws li gastrulation, neurulation, thiab organogenesis. Txawm li cas los xij, kev poob haujlwm ntawm E-cadherins ua rau muaj kev cuam tshuam thiab metastasis ntawm cov qog.
Integrin yog dab tsi?
Integrin yog lub cell adhesion molecule uas yog qhov tseem ceeb hauv cell rau extracellular matrix adhesion. Nws yog ib qho transmembrane receptor uas tsuas yog pab txhawb lub cell rau extracellular matrix adhesion. Raws li ligand binding, nws activates ntau yam teeb liab transduction txoj kev uas kho qhov sib txawv cellular zog xws li kev tswj ntawm lub cell voj voog, lub koom haum ntawm lub intracellular cytoskeleton, txav ntawm tshiab receptors rau lub cell membrane. Lub xub ntiag ntawm integrins pab sai thiab hloov tau cov lus teb rau cov xwm txheej sib txawv ntawm lub xov tooj ntawm tes. 24 hom sib txawv ntawm intergrin muaj nyob rau hauv vertebrates. Qee tus ntawm lawv yog α1β1, α2β1, α3β1, α4β1, α5β1, α6β1, α7β1, αLβ2, αVβ1, thiab lwm yam.
Daim duab 02: Integrin
Integrin yog ib lub luag haujlwm heterodimer. Integrin muaj nyob rau hauv tag nrho cov tsiaj hlwb thaum integrin-zoo li receptors tuaj yeem pom hauv cov nroj tsuag hlwb. Nws muaj ob lub luag haujlwm tseem ceeb: kev sib txuas ntawm cov hlwb mus rau extracellular matrix (ECM) thiab cov teeb liab hloov ntawm ECM mus rau lub hlwb. Nws kuj muaj cov haujlwm lom neeg xws li extravasation, cell mus rau cell adhesion, cell migration, ua cov receptors rau ntau tus kab mob xws li adenovirus, echovirus, hantavirus, poliovirus, thiab lwm yam. Tsis tas li ntawd, nws plays lub luag haujlwm tseem ceeb hauv kev tsim cov ntshav txhaws. Cov ligands rau integrin muaj xws li fibronectin, vitronectin, collagen, thiab laminin.
Dab tsi yog qhov zoo sib xws ntawm Cadherin thiab Integrin?
- Cadherin thiab integrin yog cell adhesion molecules.
- ob leeg yog cov protein.
- Lawv yog calcium-dependent.
- Lawv qhia txawv txawv ua rau mob qog noj ntshav.
- Ob leeg ntawm lawv tuaj yeem ua tau rau ntau yam ligands.
Qhov txawv ntawm Cadherin thiab Integrin yog dab tsi?
Cadherin yog lub cell adhesion molecule uas yog qhov tseem ceeb hauv cell rau cell adhesion thaum integrin yog cell adhesion molecule uas tseem ceeb hauv cell rau extracellular matrix adhesion. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm cadherin thiab integrin. Tsis tas li ntawd, cadherin yog homodimer, thaum integrin yog heterodimer.
Cov infographic hauv qab no teev qhov sib txawv ntawm cadherin thiab integrin hauv daim ntawv teev npe.
Summary – Cadherin vs Integrin
Cell adhesion molecules yog cov proteins uas ncaj qha koom rau hauv adhesion ntawm ib lub xovtooj mus rau lwm tus lossis mus rau extracellular matrix. Cadherin thiab integrin yog ob hom calcium-dependent cell adhesion molecules. Cadherin yog qhov tseem ceeb hauv cell rau cell adhesion thaum integrin yog qhov tseem ceeb hauv cell rau extracellular matrix adhesion. Yog li, qhov no yog cov ntsiab lus ntawm qhov sib txawv ntawm cadherin thiab integrin.
