Qhov sib txawv tseem ceeb ntawm E thiab N cadherin yog tias E cadherin yog downregulated thaum Epithelial-to-Mesenchymal Transition (EMT) nyob rau hauv cov qog nqaij hlav thaum N cadherin yog upregulated thaum EMT nyob rau hauv cov qog nqaij hlav.
Cadherin yog ib qho molecule uas tseem ceeb hauv kev tsim cov adherens junctions thaum khi hlwb nrog ib leeg. Yog li ntawd, lawv yog cell adhesion molecules uas yog transmembrane proteins. Cadherins nyob ntawm calcium ions thiaj li ua tau. Muaj ntau hom cadherins. E cadherin thiab N cadherin yog ob hom ntawm lawv. Lawv muab cov qauv zoo sib xws, tab sis lawv tau nthuav tawm hauv cov ntaub so ntswg sib txawv.
E Cadherin yog dab tsi?
E cadherin lossis epithelial cadherin lossis CDH1 yog hom I classical cadherin molecule pom nyob rau hauv cov ntaub so ntswg epithelial. Qhov loj ntawm E cadherin molecule yog 120 kDa. Qhov no molecule yog heev nthuav. E cadherin tsim cov cadherin-catenin complex. Nws khi nrog lub isoform luv ntawm p120 catenin. E cadherin kuj tseem hu ua suppressor ntawm ntxeem tau vim nws yog ib tug muaj zog qog suppressor.
Daim duab 01: Cadherin
Kev poob haujlwm ntawm E cadherin cuam tshuam nrog kev nce ntxiv thiab kev mob qog noj ntshav vim E cadherin txo qis- tswj thaum EMT hauv cov qog nqaij hlav. Yog li ntawd downregulation ntawm E cadherin feem ntau pom muaj nyob rau hauv malignant epithelial qog nqaij hlav. Ntxiv mus, kev tawm tsam ntawm kev qhia ntawm E cadherin tuaj yeem ua rau muaj kev cuam tshuam hauv zos thiab qhov kawg ntawm kev loj hlob qog.
N Cadherin yog dab tsi?
N cadherin yog lwm hom cadherin uas yog hom I classical cadherins. Nws yog hu ua Neuronal cadherin lossis cadherin-2 (CDH2). N cadherins muaj nyob rau hauv cov ntaub so ntswg uas tsis yog epithelial. Lawv muaj nyob rau hauv neural hlwb, endothelial hlwb, stromal hlwb, thiab osteoblasts. Qhov loj ntawm N cadherin yog 130 kDa. Zoo ib yam li E cadherin, N cadherin kuj rhiab heev rau calcium ions. N cadherin kuj tsim cov cadherin-catenin complex. Nws khi nrog lub isoform ntev ntawm catenin.
Daim duab 02: N Cadherin
N cadherin feem ntau yog kho cov cell-cell adhesions ntawm neuronal thiab qee hom cell non-neuronal. Hauv cov hlab ntsha, N cadherin txhawb nqa angiogenesis los ntawm kev tsim cov nplaum nplaum ntawm cov hlwb endothelial thiab pericyte. Kev tswj hwm ntawm N cadherin tshwm sim hauv EMT. N-cadherin ua rau EMT thiab mob qog noj ntshav zoo li tus yam ntxwv.
Dab tsi zoo sib xws ntawm E thiab N Cadherin?
- E- thiab N-cadherin belongs rau hom-I classical cadherins.
- E thiab N cadherin yog cov neeg sawv cev ntawm adherens junction.
- Ob leeg sib koom ua haujlwm zoo sib xws.
- Lawv yog ib qho proteins.
- Lawv tsim homophilic cuam tshuam nrog tib lub molecules ntawm lwm lub hlwb, yog li tso cai rau kev sib cuam tshuam ntawm tes.
- Kev tswj hwm ntawm N-cadherin yog ua raws li kev tswj hwm ntawm E-cadherin thaum lub sijhawm EMT.
- Lawv rhiab heev rau Ca2+ thiab tau yooj yim degraded los ntawm proteolysis thaum tsis muaj Ca2+.
Qhov txawv ntawm E thiab N Cadherin yog dab tsi?
E cadherin muaj nyob rau hauv cov ntaub so ntswg epithelial thaum N cadherin pom nyob rau hauv neural hlwb. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm E thiab N cadherin. Tsis tas li ntawd, thaum lub sij hawm EMT, E cadherin yog downregulated thaum N cadherin yog upregulated.
Ntxiv mus, lwm qhov sib txawv ntawm E thiab N cadherin yog tias E cadherin khi nrog lub isoform luv ntawm p120 catenin thaum N-cadherin khi nrog isoform ntev dua. Cadherins yog ib qho tseem ceeb hauv kev tswj cov cell thiab cov ntaub so ntswg thiab cellular txav. Tsis tas li ntawd, lawv ua lub luag haujlwm tseem ceeb hauv kev hloov pauv ntawm epithelial-mesenchymal. EMT ua rau txo qis ntawm cell adhesion thiab txhim kho kev tsiv teb tsaws lossis cuam tshuam hauv cov qog nqaij hlav.
Hauv qab infographic teev qhov sib txawv ntawm E thiab N cadherin hauv daim ntawv teev npe rau ib sab ntawm kev sib piv.
Summary – E vs N Cadherin
E cadherin thiab N cadherin yog calcium nyob ntawm cell adhesion molecules. Lawv yog ib qho membrane proteins uas tsim adherence junctions. E cadherin muaj nyob rau hauv cov ntaub so ntswg epithelial thaum N cadherin tau nthuav dav hauv cov ntaub so ntswg neural. Thaum lub sij hawm EMT, E-cadherin yog downregulated thaum N cadherin yog upregulated. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm E thiab N cadherin.
