Qhov sib txawv tseem ceeb ntawm collagen 1 2 thiab 3 yog collagen 1 yog collagen ntau tshaj plaws hauv cov tsiaj nyeg thiab pom nyob rau hauv daim tawv nqaij, tendons, ligaments, thiab pob txha, whereas collagen 2 yog collagen ntau tshaj nyob rau hauv pob txha mos. Meanwhile, collagen 3 yog qhov thib ob ntau tshaj collagen pom nyob rau hauv peb lub cev thiab pom nyob rau hauv ntau ntau nyob rau hauv txoj hnyuv, nqaij, hlab ntsha, thiab lub tsev menyuam.
Collagen yog ib qho tseem ceeb ntawm cov protein uas pom nyob rau hauv cov kab mob extracellular ntawm ntau yam kab mob sib txuas hauv cov tsiaj thiab tib neeg. Nws yog cov protein ntau tshaj plaws nyob rau hauv cov tsiaj. Collagen muaj nyob rau hauv daim ntawv ntawm ntev nyias fibrils uas nyuaj heev thiab insoluble. Collagens yog encoded los ntawm gene tsev neeg COL, thiab muaj 45 sib txawv collagen encoding noob nyob rau hauv tsev neeg no. Muaj kwv yees li kaum rau ntau hom collagen. Ntawm lawv, hom 1, 2 thiab 3 yog qhov ntau tshaj plaws. Cov hom no sib txawv nrog kev sib dhos ntawm cov saw hlau polypeptide, qhov ntev ntawm lub helix, cuam tshuam hauv lub helix thiab qhov sib txawv ntawm qhov kev txiav tawm ntawm lub helixes, thiab lwm yam.
YCollagen 1 yog dab tsi?
Hom 1 collagen lossis collagen 1 yog collagen ntau tshaj plaws hauv lub cev. Nws suav rau approx. 90% ntawm tag nrho cov collagen nyob rau hauv lub cev. Nws muaj nyob rau hauv ntau yam ntawm lub cev xws li daim tawv nqaij, leeg, vascular ligature, kab mob thiab pob txha. Nws yog thawj collagen yam ntxwv vim nws cov nplua nuj nyob rau hauv extracellular matrix thiab yooj yim ntawm kev sib cais.
Daim duab 01: Collagen 1
Collagen 1 muaj ob txoj hlua alpha1 thiab ib qho alpha2 saw nrog txhua tus muaj 1050 tus lej ntawm cov amino acids. Collagen 1 fibers txhawb cov tawv nqaij, nqaij, pob txha, thiab plaub hau thiab ntsia hlau loj hlob thiab tu.
YCollagen 2 yog dab tsi?
Hom 2 collagen lossis collagen 2 yog lub ntsiab lus tseem ceeb ntawm cov txheej txheem ntxiv ntawm cov pob txha mos. Nws suav txog 50% ntawm cov pob txha mos protein. Hom 2 collagen muaj nyob rau hauv cov pob txha mos matrix crosslinked nrog cov proteoglycans. Nws muaj nyob rau hauv vertebral disks, puab pob ntseg thiab lub vitreous. Collagen 2 yog tsim los ntawm peb pro alpha1 chains. COL2A1 noob yog encoded rau kev qhia ntawm hom 2 collagen nyob rau hauv lub cev.
Daim duab 02: Collagen 2
Collagen 2 ua rau cov kua dej thiab ua haujlwm hauv pob txha mos thiab pob qij txha. Hom 2 collagen synthesis yog txo nrog lub hnub nyoog, thiab nws yog noj raws li qhov ncauj pab rau kev sib koom tes thiab pob txha mos noj qab haus huv. Hom 2 collagen hmoov, muab rho tawm los ntawm nqaij qaib sternum yog qhov zoo tshaj plaws ntawm collagen 2.
YCollagen 3 yog dab tsi?
Hom 3 collagen lossis collagen 3 yog qhov thib ob ntau tshaj collagen hauv peb lub cev. Lawv pom muaj ntau hauv cov hnyuv, cov leeg, cov hlab ntsha, thiab lub tsev menyuam. Ua ke nrog collagen 1, collagen 3 txhawb nqa daim tawv nqaij, cov leeg, pob txha noj qab haus huv, thiab plaub hau thiab ntsia hlau loj hlob thiab tu.
Daim duab 03: Collagen 3
Muaj 19 amino acids pom nyob rau hauv collagen 3. Tsis tas li ntawd, collagen 3 yog ib qho tseem ceeb rau lub plab kho thiab txhim kho daim tawv nqaij elasticity thiab hydration. Bovine Collagen Peptides yog ib qhov zoo ntawm collagen 3.
Dab tsi yog qhov zoo sib xws ntawm Collagen 1 2 thiab 3?
- Ntawm 16 ntau hom collagen hauv lub cev, collagen 1, 2 thiab 3 yog cov collagen ntau tshaj.
- Lawv pom nyob rau hauv vertebrates.
- YLawv yog cov protein.
- Lawv txhawb peb cov pob txha.
- Ntxiv mus, lawv muab elasticity rau peb cov tawv nqaij.
- Txhua peb hom yog fibrillar.
- Muaj cov tshuaj ntxiv rau peb hom txhawm rau ua kom koj cov tawv nqaij, pob txha thiab pob qij txha noj qab nyob zoo
Qhov txawv ntawm Collagen 1 2 thiab 3 yog dab tsi?
Collagen 1 yog collagen ntau tshaj plaws hauv peb lub cev thiab nws muaj nyob rau hauv ntau lub cev xws li tawv nqaij, leeg, vascular ligature, kab mob thiab cov pob txha thaum collagen 2 yog cov protein ntau tshaj plaws hauv pob txha mos. Collagen 3, ntawm qhov tod tes, yog qhov thib ob ntau tshaj collagen hauv peb lub cev thiab muaj nyob rau hauv cov hnyuv, cov leeg, cov hlab ntsha, thiab lub tsev menyuam. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm collagen 1 2 thiab 3. Tsis tas li ntawd, kev ua haujlwm, collagen 1 txhawb cov tawv nqaij, cov leeg, pob txha, thiab plaub hau thiab ntsia hlau loj hlob thiab kev saib xyuas, thaum collagen 2 ua rau cov kua dej thiab ua haujlwm hauv pob txha mos thiab pob qij txha. Collagen 3, ntawm qhov tod tes, txhawb cov tawv nqaij, cov leeg, pob txha, thiab plaub hau thiab ntsia hlau loj hlob thiab tu.
Nyob hauv tabulation ntawm qhov sib txawv ntawm collagen 1 2 thiab 3 nthuav qhia ib sab ntawm kev sib piv ntawm peb hom collagen.
Summary – Collagen 1 vs 2 vs 3
Collagen yog cov khoom muaj ntau tshaj plaws hauv peb lub cev. Muaj 16 hom collagen sib txawv. Ntawm lawv, collagen 1, 2 thiab 3 yog qhov ntau tshaj. Tag nrho peb yog fibrous hom collagen molecules. Collagen 1 yog ntau tshaj plaws thiab pom nyob rau hauv txhua hom kev sib txuas cov ntaub so ntswg, nrog rau cov tawv nqaij, leeg, vascular ligature, cov kabmob thiab cov pob txha, thiab lwm yam. Collagen 2 yog cov collagen loj hauv pob txha mos. Collagen 3 yog qhov thib ob ntau tshaj plaws thiab pom hauv plab hnyuv, cov leeg thiab cov hlab ntsha. Tag nrho peb hom yog qhov tseem ceeb txhawm rau ua kom peb cov tawv nqaij, pob txha thiab pob qij txha noj qab nyob zoo. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm collagen 1 2 thiab 3.
