Qhov sib txawv tseem ceeb ntawm depolarizing thiab nondepolarizing neuromuscular blockers yog tias depolarizing neuromuscular blockers ua raws li acetylcholine receptor agonists thaum nondepolarizing neuromuscular blockers ua raws li kev sib tw antagonists.
Neuromuscular blockers feem ntau yog siv rau cov leeg pob txha so. Lawv kuj hu ua skeletal leeg relaxants. Lawv thaiv kev sib kis ntawm neuromuscular ntawm qhov sib txuas ntawm neuromuscular (kev sib txuas ntawm neuron thiab cov leeg). Yog li ntawd, cov leeg nqaij tsis sib cog lus thiab tseem so. Neuromuscular blocking tshuaj muaj txiaj ntsig zoo hauv kev phais. Muaj ob hom neuromuscular thaiv cov neeg ua haujlwm uas ua haujlwm ntawm kev sib tshuam neuromuscular. Lawv yog depolarizing thiab nondepolarizing neuromuscular blockers. Depolarizing neuromuscular blockers ua haujlwm ua acetylcholine receptor agonists. Hauv kev sib piv, nondepolarizing neuromuscular blockers ua haujlwm raws li kev sib tw antagonists. Neuromuscular blocking agents feem ntau yog cov qauv analogs ntawm acetylcholine.
Dab tsi yog Depolarizing Neuromuscular Blockers?
Depolarizing neuromuscular blockers yog ib qho ntawm ob hom tshuaj tiv thaiv neuromuscular. Lawv tsis muaj kev sib tw rau cov chaw sib txuas ntawm acetylcholine rau receptors. Yog li ntawd, lawv ua haujlwm li acetylcholine receptor agonists los ntawm kev khi rau Ach receptors. Lawv tsis degrade ib zaug lawv khi rau receptors, tsis zoo li acetylcholine degraded los ntawm acetylcholinesterase.
Daim duab 01: Succinylcholine
Lawv tiv taus, yog li lawv tsis metabolize thiab tseem khi. Yog li ntawd, depolarization ntawm cov leeg nyob twj ywm rau lub sij hawm ntev dua yam tsis tau cia lub endplate rau repolarize. Nws ua rau cov leeg fasciculations thiab tuag tes tuag taw ntawm tus neeg mob. Thaum kawg, cov leeg yuav so. Succinylcholine yog tus paub zoo tshaj plaws depolarizing neuromuscular thaiv tus neeg sawv cev. Nws yog ib qho piv txwv ntawm acetylcholine.
Dab tsi yog Nondepolarizing Neuromuscular Blockers?
Nondepolarizing nqaij blockers yog kev sib tw antagonists. Lawv sib tw nrog acetylcholine rau kev khi nrog receptors thiab tiv thaiv kev khi ntawm acetylcholine nrog cov receptors. Txawm hais tias lawv yog cov qauv analogues ntawm acetylcholine, thaum lawv khi, lawv tsis tsim kom muaj peev xwm ua tau, tsis zoo li acetylcholine. Yog li ntawd, neural endplate muaj peev xwm tsis tsim. Vim li ntawd, cov leeg thiaj li so.
Daim duab 02: Nondepolarizing Neuromuscular Blocker - Doxacurium
Ua li no, nondepolarizing blocker tiv thaiv cov leeg nqaij. Nondepolarizing neuromuscular blockers tuaj yeem ua haujlwm ntev, nruab nrab lossis luv luv. Tubocurarine, doxacurium, pancuronium, vecuronium, thiab pipecuronium yog ob peb nondepolarizing neuromuscular blockers.
Dab tsi zoo sib xws ntawm Depolarizing thiab Nondepolarizing Neuromuscular Blockers?
- Depolarizing thiab nondepolarizing neuromuscular blockers yog ob hom neuromuscular blockers uas ua haujlwm ntawm kev sib tshuam neuromuscular.
- Ob leeg khi rau Ach receptors.
- Lawv yog cov qauv analogs ntawm acetylcholine.
- Lawv tiv thaiv cov leeg nqaij thiab ua rau cov leeg so.
- Ntxiv mus, lawv tau siv thaum phais.
Qhov txawv ntawm Depolarizing thiab Nondepolarizing Neuromuscular Blockers yog dab tsi?
Depolarizing neuromuscular blockers yog cov tshuaj uas ua raws li acetylcholine agonists thaum nondepolarizing neuromuscular blockers yog cov tshuaj uas ua raws li kev sib tw antagonists. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm depolarizing thiab nondepolarizing neuromuscular blockers.
Ntxiv mus, cov depolarizing neuromuscular blockers tso cai depolarization ntawm cov leeg thaum lub nondepolarizing neuromuscular blockers tsis tso cai depolarization. Yog li, qhov no yog lwm qhov sib txawv loj ntawm depolarizing thiab nondepolarizing neuromuscular blockers.
Cov hauv qab no infographic tabulates ntau qhov sib txawv ntawm depolarizing thiab nondepolarizing neuromuscular blockers.
Summary – Depolarizing vs Nondepolarizing Neuromuscular Blockers
Depolarizing thiab nondepolarizing neuromuscular blockers yog ob hom neuromuscular thaiv cov tshuaj lossis cov leeg pob txha. Depolarizing neuromuscular blockers yog tsis sib tw rau acetylcholine binding qhov chaw ntawm cov receptors. Hauv kev sib piv, nondepolarizing neuromuscular blockers yog kev sib tw rau cov chaw sib txuas hauv cov receptors. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm depolarizing thiab nondepolarizing neuromuscular blockers. Ntxiv mus, raws li qhov tshwm sim ntawm kev ua ntawm depolarizing blockers, depolarization ntawm cov leeg yuav tshwm sim thaum vim qhov kev txiav txim ntawm nondepolarizing blockers, depolarization tsis tshwm sim.
