Qhov sib txawv tseem ceeb ntawm AMPA thiab NMDA receptors yog qhov tshwj xeeb agonist ntawm AMPA receptor yog alpha-amino - 3 - hydroxyl - 5 - methyl - 4 - isoxazole propionic acid (AMPA), thaum lub agonist tshwj xeeb ntawm NMDA receptor yog N – methyl – D – aspartate (NMDA).
Muaj peb yam tseem ceeb ntawm glutamate receptors. Lawv qhov sib txawv yog nyob ntawm tus agonist uas khi rau kev ua kom cov receptor rau glutamate khi. Glutamate khi yuav qhib cov ion gated channel rau kev thauj cov sodium thiab potassium ions. Tsis tas li ntawd, NMDA receptors kuj pab txhawb lub flux ntawm calcium ions thoob plaws hauv daim nyias nyias.
AMPA Receptors yog dab tsi?
Lub sijhawm AMPA receptor yog daim ntawv luv ntawm alpha-amino - 3 - hydroxyl - 5 - methyl - 4 - isoxazole propionic acid receptor. Cov receptor no tseem hu ua AMPAR lossis quisqualate. Nws yog ib hom Glutamate receptor thiab yog ionotropic receptor. AMPA receptor yog ib qho transmembrane receptor uas nkag mus rau hauv cov ntshav plasma lub lipid bilayer. Cov glutamate ua raws li ligand los khi rau AMPA receptor.
Daim duab 01: AMPA Receptors
Tus receptor kuj muaj peev xwm ua kom AMPA, uas yog agonist analogue ntawm glutamate. Yog li, tus receptor tau txais lub npe AMPA receptor. Tsis tas li ntawd, tus receptor yog dav faib nyob rau hauv lub hlwb thiab lub paj hlwb. Nws yog tsuas yog vim lub luag haujlwm glutamate plays hauv kev sib koom tes ntawm lub paj hlwb thiab teeb liab.
Tsis tas li ntawd, muaj plaub hom subunits hauv AMPA receptor. Thiab, cov noob sib txawv encode txhua subunit. Yog li ntawd, kev hloov pauv hauv cov noob no encoding cov subunits yuav ua rau muaj kev ua haujlwm tsis zoo ntawm tag nrho cov receptor tag nrho. Li no, AMPA receptor kuj yog cov protein ntau heterotetrameric. Vim yog cov qauv no, glutamate lossis nws cov agonists tuaj yeem khi rau ib qho ntawm plaub subunits rau kev ua kom.
NMDA Receptors yog dab tsi?
NMDA receptor yog cov ntawv luv rau N - methyl - D - aspartate receptor. Nws tseem hu ua NMDAR. NMDA receptor yog ib hom glutamate receptor uas yog ionotropic hauv xwm. Lub receptor muaj npe tom qab agonist uas ua kom lub receptor. NMDA receptor yog ib channel protein uas yog tsim los ntawm peb subunits, encoded los ntawm peb noob. Lawv feem ntau faib rau hauv cov hlab ntsha.
Kev ua kom lub NMDA receptor rau kev khi ntawm glutamate tshwm sim nyob rau hauv lub xub ntiag ntawm glycine los yog serine. Qhov no yog hu ua kev sib koom tes ntawm NMDA receptor. Thaum khi, qhov nkag ntawm cov ions zoo yog pib. Kev khi ntawm agonist NMDA yog tshwj xeeb rau NMDA receptor.
Daim duab 02: NMDA Receptors
Lub luag haujlwm tseem ceeb ntawm NMDA receptor yog los pab hauv cov txheej txheem hloov pauv hauv cov paj hlwb. Yog li, lawv qhib depolarization los ntawm kev tso cai rau Sodium thiab potassium ion txav. Tsis tas li ntawd, lub luag haujlwm ntawm NMDA receptor kuj nthuav dav hauv kev txhawb nqa synaptic plasticity. Qhov no yog kho los ntawm lub peev xwm ntawm NMDA receptor tso cai Calcium ion flux.
Qhov Zoo sib xws ntawm AMPA thiab NMDA Receptors yog dab tsi?
- AMPA thiab NMDA receptors yog hom glutamate receptors.
- Ob leeg feem ntau muaj nyob rau hauv paj hlwb thiab pab txhawb kev xa paj hlwb.
- Lawv yog ionotropic receptors.
- Ob leeg muaj nyob rau hauv cov ntshav plasma.
- Ntxiv mus, lawv qhia qhov tshwj xeeb.
- Ob leeg tuaj yeem tswj hwm los ntawm tshuaj.
- Tsis tas li ntawd, lawv pab txhawb kev txav ntawm ions hla lub membrane
- Ob hom proteins muaj ntau lub subunits coded los ntawm cov noob sib txawv.
- Ntxiv mus, ob qho tib si yog heteromeric proteins.
Qhov txawv ntawm AMPA thiab NMDA Receptors yog dab tsi?
Qhov sib txawv tseem ceeb ntawm AMPA thiab NMDA receptors yog raws li lawv cov agonists. Thaum AMPA receptors muaj alpha-amino - 3 - hydroxyl - 5 - methyl - 4 - isoxazole propionic acid raws li nws cov agonist, N - methyl - D - aspartate yog agonist rau NMDA receptor. Vim qhov kev hloov pauv no hauv hom agonist, kev hloov pauv ntxiv tshwm sim hauv ob lub receptors. Hauv NMDA receptors, co-stimulation yog yuav tsum tau, tab sis nws tsis tas yuav tsum tau rau AMPA receptors. Lawv cov qauv kuj txawv raws li tus naj npawb ntawm subunits txhua tus receptor muaj. AMPA receptors muaj plaub subunits, thaum NMDA receptors muaj peb subunits.
Cov lus qhia hauv qab no qhia txog qhov sib txawv ntawm AMPA thiab NMDA Receptors.
Summary – AMPA vs NMDA Receptors
AMPA thiab NMDA yog ob lub receptors uas pab txhawb glutamate khi. Qhov sib txawv ntawm AMPA thiab NMDA receptors yog nyob ntawm agonist txhua tus siv rau kev ua kom lub receptor. Thaum lub AMPA receptor siv alpha-amino - 3 - hydroxyl - 5 - methyl - 4 - isoxazole propionic acid, NMDA siv N - methyl - D - aspartate ua tus agonist. Cov qauv ntawm ob receptors sib txawv nyob rau hauv tus naj npawb ntawm subunits txhua tus muaj. Tsis tas li ntawd, NMDA receptor yuav tsum muaj kev sib koom ua ke ntawm cov receptor nrog glycine lossis serine, thaum AMPA receptor tsis xav tau kev sib koom tes rau nws qhov kev ua haujlwm.
