Qhov txawv ntawm angiotensin 1 thiab 2 yog tias angiotensin 1 yog tsim los ntawm angiotensinogen los ntawm kev ua ntawm renin enzyme, thaum angiotensinogen 2 yog tsim los ntawm angiotensin 1 los ntawm kev ua ntawm angiotensin-hloov enzyme.
Angiotensin yog peptide uas ua rau cov leeg du thiab nce ntshav siab. Muaj peb hom angiotensins: angiotensin 1, 2 thiab 3. Angiotensinogen hloov mus rau angiotensin 1 los ntawm catalysis ntawm renin enzyme. Angiotensin 1 hloov mus rau hauv angiotensin 2 los ntawm kev ua ntawm angiotensin-hloov enzyme. Nws yog hom angiotensin uas ncaj qha ua rau cov hlab ntsha, ua rau constrictions thiab nce ntshav siab. Angiotensin 3, ntawm qhov tod tes, yog cov metabolite ntawm angiotensin 2.
Angiotensin 1 yog dab tsi?
Angiotensin 1, tseem hu ua pro-angiotensin, yog cov protein tsim los ntawm angiotensinogen los ntawm kev ua ntawm renin. Nws yog nyob rau hauv daim ntawv tsis muaj zog thiab hloov mus rau angiotensin 2 vim qhov kev txiav txim ntawm angiotensin-hloov enzyme.
Daim duab 01: Renin-Angiotensin Pathway
Angiotensin Kuv tsis muaj kev ua haujlwm lom neeg ncaj qha. Tab sis, nws ua raws li lub hauv paus molecule rau angiotensin 2. Angiotensin 2 theem yog qhov nyuaj rau ntsuas. Yog li, qib angiotensin I yog ntsuas raws li kev ntsuas ntawm renin kev ua haujlwm los ntawm kev thaiv kev tawg ntawm angiotensin 1 los ntawm inhibiting plasma-hloov enzyme thiab proteolysis los ntawm angiotensinases.
Angiotensin 2 yog dab tsi?
Angiotensin 2 yog cov protein tsim los ntawm angiotensin 1 los ntawm kev ua ntawm angiotensin-hloov enzyme (ACE). Yog li, angiotensin 1 yog lub hauv paus rau angiotensin 2. Lub luag haujlwm tseem ceeb ntawm angiotensin 2 yog kev txwv ntawm cov hlab ntsha kom nce ntshav siab. Ntxiv rau qhov ua haujlwm ncaj qha ntawm cov hlab ntsha, angiotensin 2 ua haujlwm ntau yam cuam tshuam nrog rau lub raum, qog adrenal, thiab cov hlab ntsha. Angiotensin 2 ua rau muaj kev hnov qab nqhis dej thiab xav tau ntsev. Hauv cov qog adrenal, angiotensin 2 txhawb kev tsim cov aldosterone. Hauv ob lub raum, nws nce sodium retention thiab hloov txoj kev lub raum lim ntshav.
Daim duab 02: Angiotensin 1 thiab 2
Angiotensin 2 yuav tsum tau tswj hwm ntawm theem tsim nyog hauv lub cev. Ntau dhau ntawm angiotensin 2 ua rau khaws cov kua dej ntau hauv lub cev. Hauv qhov sib piv, qib qis ntawm angiotensin 2 ua rau tuav cov poov tshuaj, poob ntawm sodium, txo cov kua dej thiab ntshav siab, thiab lwm yam.
Dab tsi yog qhov zoo sib xws ntawm Angiotensin 1 thiab 2?
- Angiotensin 1 hloov mus ua angiotensin 2. Yog li, angiotensin 1 yog qhov ua ntej rau angiotensin 2.
- Kev hloov pauv ntawm angiotensin 1 rau hauv 2 tuaj yeem thaiv los ntawm cov tshuaj uas inhibit ACE.
Qhov txawv ntawm Angiotensin 1 thiab 2 yog dab tsi?
Angiotensin 1 yog cov protein uas ua raws li lub hauv paus molecule rau angiotensin 2 thaum angiotensin 2 yog cov protein uas ncaj qha ua rau cov hlab ntsha rau constriction thiab nce ntshav siab. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm angiotensin 1 thiab 2. Tsis tas li ntawd, lwm qhov sib txawv tseem ceeb ntawm angiotensin 1 thiab 2 yog tias angiotensin 1 yog cov protein tsis muaj zog, thaum angiotensin 2 yog ib qho active molecule.
Tsis tas li ntawd, renin yog cov enzyme uas ua rau kev tsim cov angiotensin 1 thaum lub angiotensin-hloov enzyme yog cov enzyme uas catalyzes cov synthesis ntawm angiotensin 2. Functionally, angiotensin 1 yog ib qho tseem ceeb precursor rau angiotensin 2 thaum angiotensin 2. lub luag haujlwm rau kev nce ntshav siab, dej hauv lub cev thiab cov ntsiab lus sodium. Yog li, ntawm qhov ua haujlwm zoo, qhov no kuj yog qhov sib txawv ntawm angiotensin 1 thiab 2.
Summary – Angiotensin 1 vs 2
Angiotensin 1 thiab angiotensin 2 yog ob hom angiotensins, uas yog cov proteins. Angiotensin 1 tsis muaj tshuaj lom neeg. Nws yog nyob rau hauv daim ntawv inactive. Tab sis, nws ua hauj lwm raws li lub precursor molecule rau tsim ntawm angiotensin 2. Ntawm qhov tod tes, angiotensin 2 yog cov active daim ntawv uas ua rau cov hlab ntsha ua nqaim. Nws pab tswj cov ntshav siab thiab kua dej sib npaug hauv lub cev. Yog li, qhov no qhia txog qhov sib txawv ntawm angiotensin 1 thiab 2.
