Qhov sib txawv tseem ceeb ntawm kev faib coefficient thiab kev faib coefficient yog qhov sib faib coefficient yog hais txog qhov sib xyaw ntawm cov tshuaj tsis muaj ionized ntawm cov khoom sib xyaw uas qhov sib faib coefficient yog hais txog qhov concentration ntawm ob qho tib si ionized thiab un-ionized tshuaj hom ntawm ib tug compound.
Ob nqe lus muab faib coefficient thiab faib coefficient feem ntau yog siv sib hloov vim ob lo lus no yuav luag qhia tib lub tswv yim txog kev faib cov tshuaj ntawm ob hom tshuaj. Txawm li cas los xij, cov ntsiab lus no txawv ntawm ib leeg nyob ntawm cov hom tshuaj uas peb tab tom txiav txim siab hauv kev suav.
Partition Coefficient yog dab tsi?
Qhov sib faib coefficient yog qhov sib piv ntawm cov concentrations ntawm un-ionized hom ntawm ib tug compound nyob rau hauv ib tug sib tov ntawm ob theem immiscible. Peb feem ntau qhia qhov tshwm sim no ua "P". Ob theem sib txawv yuav tsum nyob rau hauv sib npaug zos rau ib leeg los txiav txim qhov muab faib coefficient ntawm ob-theem system. Qhov piv no sawv cev rau qhov ntsuas ntawm kev solubility ntawm txhua hom un-ionized hauv qhov sib tov.
Daim duab 01: Kev txiav txim siab ntawm kev faib cov coefficient hauv daim duab
Feem ntau, ob theem immiscible peb xav txog ntawm no yog cov kuab tshuaj. Feem ntau, nws yog dej-organic hnyav system. Yog li ntawd, peb feem ntau xav txog hydrophilic-hydrophobic systems thaum txiav txim siab muab faib coefficient. Nyob ntawd, qhov sib faib coefficient yog ntsuas ntawm lipophilicity lossis hydrophobicity ntawm cov kua uas peb xav tau. Qhov tshwm sim no tseem ceeb heev hauv kev txiav txim siab faib tshuaj thoob plaws hauv peb lub cev.
Dab tsi yog qhov sib faib coefficient?
Kev faib tawm coefficient yog qhov sib piv ntawm cov concentration ntawm ob qho tib si ionized thiab un-ionized hom ntawm ib qho kev sib xyaw ua ke ntawm ob theem immiscible. Peb tuaj yeem pom qhov tshwm sim no ua "D". Ntawm no, ib qho ntawm ob theem immiscible yog qhov tseem ceeb dej los yog cov kua dej aqueous. Lwm theem yog feem ntau yog hydrophobic theem uas yog immiscible nrog dej (los yog lwm yam aqueous theem peb siv no). Feem ntau, peb muab tus nqi no ua tus nqi logarithmic vim nws yog tus nqi me me.
Dab tsi yog qhov sib txawv ntawm Kev faib Coefficient thiab Kev faib Coefficient?
Txawm tias peb siv cov ntsiab lus muab faib coefficient thiab faib coefficient sib hloov, lawv txawv ntawm ib leeg. Qhov sib txawv tseem ceeb ntawm kev faib coefficient thiab kev faib coefficient yog tias lub sij hawm muab faib coefficient yog hais txog qhov concentration ntawm un-ionized chemical hom ntawm ib tug compound thaum lub sij hawm faib coefficient yog hais txog cov concentration ntawm ob qho tib si ionized thiab un-ionized tshuaj hom ntawm ib tug compound.
Thaum txiav txim siab txog ob theem immiscible, hauv kev txiav txim siab muab faib coefficient, peb feem ntau siv cov dej sib xyaw ua ke thiab theem hydrophobic thaum txiav txim siab qhov sib faib coefficient peb tseem ceeb siv cov theem aqueous nrog rau lwm theem tsim nyog.
Cov lus hauv qab no qhia txog qhov sib txawv ntawm qhov sib faib coefficient thiab faib coefficient.
Summary – Partition Coefficient vs Distribution Coefficient
Txawm tias peb siv cov ntsiab lus muab faib coefficient thiab faib coefficient sib hloov, lawv txawv ntawm ib leeg. Cov ntsiab lus no txawv ntawm ib leeg nyob ntawm hom tshuaj uas peb xav txog rau txhua qhov kev suav. Qhov sib txawv tseem ceeb ntawm kev faib coefficient thiab kev faib coefficient yog tias lub sij hawm muab faib coefficient yog hais txog qhov concentration ntawm un-ionized chemical hom ntawm ib tug compound thaum lub sij hawm faib coefficient yog hais txog cov concentration ntawm ob qho tib si ionized thiab un-ionized tshuaj hom ntawm ib tug compound.
