Qhov Tseem Ceeb Qhov txawv - Cytokines vs Interleukins
Ib qho tshuaj tiv thaiv kab mob yog ib qho tshuaj tiv thaiv kab mob uas tshwm sim los ntawm kev kis kab mob. Txhawm rau pib lub cev tiv thaiv kab mob, qee cov tshuaj tau tso tawm los ntawm lub cev tiv thaiv kab mob. Lub xub ntiag ntawm cov tshuaj inflammatory no ua raws li biomarker rau ntau qhov chaw kho mob. Cytokines yog cov protein me me uas tso tawm los ntawm cov hlwb hauv cov lus teb rau qhov mob tom qab kis kab mob thiab suav nrog ntau yam xws li chemokines, interleukins, thiab interferons. Interleukins yog proteins secreted los ntawm leukocytes uas ua rau lwm hom leukocyte. Qhov sib txawv tseem ceeb ntawm cytokines thiab interleukins yog tias cytokines muaj nyob rau ntau pawg ntawm cov tshuaj molecules uas ua rau mob, thaum interleukins yog ib pawg ntawm pawg loj uas tshwj xeeb ua rau leukocytes.
Cytokines yog dab tsi?
Cytokines yog cov xov tooj ntawm tes taw qhia cov khoom lag luam uas pab cov xov tooj ntawm tes sib txuas lus hauv lub cev tiv thaiv kab mob thiab txhawb kev txav ntawm cov hlwb mus rau qhov chaw mob, kis kab mob, thiab raug mob. Cytokines yog cov protein me me uas muaj cov haujlwm tshwj xeeb. Cytokines ua raws li cov tshuaj hormones hauv cov cim qhia cov hlwb kom qhib nws lub cev tiv thaiv kab mob. Cytokines cuam tshuam ntawm cov hlwb thiab kho los ntawm receptors uas txheeb xyuas cov teeb liab ntawm cov cytokine tshwj xeeb. Cytokines yog ib pab pawg dav dav ntawm cov cim taw qhia uas suav nrog chemokines, lymphokines, adipokines, interferons, thiab interleukins.
Zoo ib yam li cov tshuaj hormones, cytokines muaj ntau txoj hauv kev uas lawv ua;
- Autocrine - ua rau tib lub cell uas nws tau zais
- Paracrine - ua rau ntawm lub xovtooj ze ze uas nws tau zais
- Endocrine- ua rau ntawm lub cell nyob deb uas nws tau zais
Nws tso tawm los ntawm cov hlwb yog hu ua Pleiotropic. Pleiotropy yog qhov xwm txheej uas muaj ntau hom cell muaj peev xwm zais ib leeg cytokine lossis rov ua dua qhov twg ib cytokine muaj peev xwm ua haujlwm ntawm ntau hom cell.
Daim duab 01: B cell activation los ntawm Cytokines
Kev tsim cov cytokines tshwm sim los ntawm kev cuam tshuam los ntawm kev cuam tshuam. Cytokines yog tsim los ntawm T Helper hlwb thiab Macrophages. Cov cytokines tsim tawm ces txheeb xyuas nws cov receptor tshwj xeeb thiab khi rau nws. Lub cytokine - receptor koom haum ntawm lub hom phiaj ntawm tes ces pib ib qho kev cuam tshuam ntawm cov tshuaj tiv thaiv uas ua rau muaj kev hloov pauv ntawm cov noob qhia kom ua rau lub cev tiv thaiv kab mob. Cytokines tuaj yeem ua haujlwm sib koom ua ke lossis antagonistically raws li nws cov txheej txheem tshuaj tiv thaiv. Qhov no tshwm sim txij li ntau tshaj ib cytokines koom nrog ua rau mob.
Cytokines tau muab faib ntxiv raws li cov cytokines pro-inflammatory thiab anti-inflammatory cytokines. Lawv ua raws li biomarkers tshwj xeeb hauv cov kab mob uas cuam tshuam nrog kev mob (uas suav nrog kev kis kab mob) thiab cov kab mob tsis sib xws xws li ntshav qab zib.
Interleukins yog dab tsi?
Interleukins (IL) yog cov protein me me uas tau qhia hauv leukocytes. Lawv yog secreted tsuas yog los ntawm leukocytes, thiab lawv ua rau lwm leukocytes. Muaj ntau hom interleukins. Li no nws functionality yog txawv. Interleukin tus txheej txheem ntawm kev txiav txim yog paracrine. Interleukins cuam tshuam rau cov hlwb nyob ze thiab hloov cov noob qhia ntawm cov protein los ntawm kev ua kom los yog inhibiting transcription. Interleukins pib ua ib qho kev cuam tshuam los ntawm kev khi rau cov chav kawm ntawm receptors hu ua tyrosine receptor kinase (TRK). Qhov no yuav qhib G protein-coupled receptors li no, ua rau cov kev hloov pauv ntawm cov proteins thib ob uas yuav cuam tshuam rau cov txheej txheem hloov pauv ntawm mRNA thiab hloov pauv cov noob qhia.
Daim duab 02: Interleukin
Interleukins muaj ntau hom thiab muaj ntau yam haujlwm. Feem ntau interleukins tuaj yeem ua raws li cov tshuaj tiv thaiv kab mob lossis cov tshuaj tiv thaiv kab mob. Pro-inflammatory ILs suav nrog IL-1β thiab IL-6. IL-1β yog zais los ntawm monocytes thiab macrophages nrog rau cov hlwb tsis muaj zog, xws li fibroblasts thiab endothelial hlwb. Cov no yog secreted thaum raug mob ntawm tes, kab mob, ntxeem tau, thiab o. IL-6 feem ntau yog zais los ntawm cov hlwb neuronal thiab koom nrog kev tswj cov proteins hauv kev ua haujlwm neuronal.
Anti-inflammatory interleukins suav nrog interleukin (IL)-1 receptor antagonist, IL-4, IL-10, IL-11, thiab IL-13. Ntawm cov no, IL-10 yog ib qho tseem ceeb los tiv thaiv interleukin. IL-10 muaj peev xwm tswj tau qhov kev qhia ntawm pro-inflammatory cytokines nrog rau IL-1β thiab IL-6. Nws kuj tseem koom nrog hauv kev tswj hwm cov tshuaj tiv thaiv kab mob receptors thiab ib txhij down-regulating cov pro-inflammatory receptors. Yog li nws ua raws li kev tswj hwm kev tswj hwm.
Dab tsi yog qhov zoo sib xws ntawm Cytokines thiab Interleukins?
- ob leeg yog protein molecules.
- Ob leeg pib cov lus teb inflammatory.
- Ob leeg tuaj yeem tiv thaiv kab mob lossis tiv thaiv kab mob.
- Ob leeg tuaj yeem ua tus cim ntawm qhov mob hauv qhov xwm txheej tshwj xeeb.
- Ob leeg khi rau cov receptors tshwj xeeb thiab pib ua ib qho cascade lossis kev tshwm sim.
- Ob qho tib si tshwm sim hauv kev hloov pauv ntawm cov noob qhia ntawm qib ntawm kev hloov pauv.
Qhov txawv ntawm Cytokines thiab Interleukins yog dab tsi?
YCytokines vs Interleukins |
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| Cytokines yog cov protein me me uas tso tawm los ntawm cov hlwb hauv kev teb rau qhov mob tom qab kis kab mob thiab suav nrog ntau yam xws li chemokines, interleukins, thiab interferons. | Interleukins yog cov protein me me uas tso tawm los ntawm leukocytes uas ua rau lwm hom leukocyte. |
| feeb | |
| Cytokine nyhuv tuaj yeem yog autocrine, paracrine lossis endocrine. | Interleukin nyhuv feem ntau yog paracrine. |
| Secretion | |
| Cytokine secretion yog pib los ntawm T Helper cells. | Interleukin secretion yog pib los ntawm cov hlwb hematopoietic. |
Summary – Cytokines vs Interleukins
Cytokines thiab interleukins yog cov protein uas zais cia rau ntawm qhov mob uas tuaj yeem ua rau lossis cuam tshuam qhov mob uas tuaj yeem txheeb xyuas tau tias yog lub cev tiv thaiv kab mob. Cytokines yog ib pawg loj ntawm cov protein molecules whereas Interleukins yog ib pawg tshwj xeeb ntawm cov protein molecules uas yog secreted los ntawm leukocytes. Qhov no tuaj yeem piav qhia qhov txawv ntawm Cytokines thiab Interleukins. Tam sim no, ntau hom kev tshawb fawb tau koom nrog hauv daim teb no vim lawv raug hu ua biomarkers ntawm o. Yog li lub xub ntiag ntawm cov biomarkers hauv cov ntshav ua raws li kev kuaj mob ntxov ntawm ntau yam kab mob thiab kev kho mob tshwm sim.
Download the PDF Version of Cytokines vs Interleukins
Koj tuaj yeem rub tawm PDF version ntawm kab lus no thiab siv nws rau offline lub hom phiaj raws li daim ntawv ceeb toom. Thov download PDF version ntawm no Qhov txawv Ntawm Cytokines thiab Interleukins
