Qhov Tseem Ceeb Qhov txawv - Cytokines vs Chemokines
Kev tiv thaiv tuaj yeem yog lub hauv paus lossis hloov tau. Nyob rau hauv lawv, kev tiv thaiv kab mob muaj ntau hom. Inflammation yog ib qho kev tiv thaiv kab mob uas tau pom nyob rau hauv ob qho tib si hauv lub cev thiab kev tiv thaiv kab mob. Kev mob tshwm sim los ntawm cov protein molecules hu ua cytokines. Cytokine yog secretory me proteins. Lawv yog secreted raws li ib tug inflammatory teb. Lawv tau muab faib ua cov chav dav dav uas suav nrog chemokines, cytokines, interleukins, thiab interferons. Chemokines yog ib hom cytokines uas koom nrog inducing chemotaxis. Qhov sib txawv tseem ceeb ntawm cytokines thiab chemokines yog tias cov cytokines muaj nyob rau hauv ntau pawg ntawm cov tshuaj molecules uas ua rau mob, hos chemokines yog ib pawg ntawm pawg loj uas muaj peev xwm induce chemotaxis.
Cytokines yog dab tsi?
Y Cytokines yog cov kab mob inflammatory uas yog cov proteins me uas zais los ntawm cov hlwb. Lawv muaj ntau yam haujlwm. Cytokines kuj ua raws li cov tshuaj hormones. Cytokines yog pib tsim los ntawm cov hlwb tshwj xeeb xws li T Helper cells thiab macrophages. Lawv khi rau ib qho receptor tshwj xeeb thiab pib ua ib qho kev cuam tshuam los ua kom lub cev tiv thaiv kab mob. ntawm lawv, receptor - cytokine complex yog qhov tshwj xeeb heev. Feem ntau cytokines ua rau hloov cov noob qhia ntawm qib transcriptional. Cytokines kuj yog ib pab pawg dav dav ntawm cov teeb liab molecules. Cov pab pawg no suav nrog chemokines, lymphokines, adipokines, interferons, thiab interleukins.
Daim duab 01: Cytokines
Cytokines muaj peb txoj hauv kev uas lawv ua;
- Autocrine - ua rau tib lub cell uas nws tau zais
- Paracrine - ua rau ntawm lub xov tooj ze ze uas nws tau zais
- Endocrine- ua rau ntawm lub cell nyob deb uas nws tau zais cia.
YCytokines yog Pleiotropic hauv qhov xwm txheej. Pleiotropy yog qhov tshwm sim uas ntau hom cell muaj peev xwm zais ib qho cytokine lossis qhov twg ib cytokine muaj peev xwm ua yeeb yam ntawm ntau hom cell. Cytokines tuaj yeem ua haujlwm sib koom ua ke lossis antagonistically. Qhov no yog vim qhov tseeb tias ntau tshaj ib qho cytokine koom nrog tsim cov tshuaj tiv thaiv inflammatory. Cytokines tuaj yeem raug cais ntxiv raws li cov cytokines pro-inflammatory cytokines thiab anti-inflammatory cytokines.
Chemokines yog dab tsi?
Chemotactic cytokines yog hu ua Chemokines. Nws yog ib pab pawg neeg sib txawv ntawm ntau hom protein molecules. Chemokines muaj qhov hnyav molecular protein ntau. Nws lub luag haujlwm tseem ceeb yog qhib leukocytes thiab pab txhawb nws txoj kev tsiv teb tsaws chaw mus rau qhov chaw. Chemokines muab faib ua 4 pawg loj. Qhov kev faib tawm no yog ua raws li cov yam ntxwv hauv kev khaws cia cysteine residues tam sim no hauv chemokines. Plaub pawg yog;
- CC chemokines
- CXC chemokine
- C chemokines (lymphotactin)
- CXXXC chemokines (fractalkine)
RANTES, monocyte chemoattractant protein lossis MCP-1, monocyte inflammatory protein lossis MIP-1α, thiab MIP-1β
Chemokines khi rau ib qho protein receptor tshwj xeeb los pib qhov kev cuam tshuam cascade. Cov receptors no suav nrog G protein-coupled receptors thiab ua rau ua kom cov GTPases me. Qhov no yuav ua rau kev npaj cov hlwb rau kev txav los ntawm kev loj hlob ntawm actin thiab actin polymerization thiab los ntawm kev loj hlob ntawm pseudopods thiab integrins.
Daim duab 02: Chemokines
Nyob ntawm kev ua haujlwm, chemokines muaj ob hom sib txawv; Inflammatory chemokines thiab homeostatic chemokines. Inflammatory chemokines induce inflammatory whereas homeostatic chemokines koom nrog hauv lymphocyte migration, kev loj hlob ntawm lymphoid organ xws li tus po thiab angiogenesis.
Dab tsi yog qhov zoo sib xws ntawm Cytokines thiab Chemokines?
- Ob leeg yog biomolecules tsim los ntawm cov proteins.
- Ob leeg yog zais rau ntawm qhov mob.
- Ob leeg muaj peev xwm los ua cov cim ntawm qhov mob hauv cov xwm txheej tshwj xeeb.
- Ob leeg khi rau cov receptors tshwj xeeb los tsim cov receptor - protein (cytokine / chemokine) complex.
- Ob leeg muaj peev xwm los pib qhov kev tshwm sim.
Qhov txawv ntawm Cytokines thiab Chemokines yog dab tsi?
YCytokines vs Chemokines |
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| Cytokines yog cov protein me me uas zais los ntawm cov hlwb hauv kev teb rau qhov mob thiab lawv muaj ntau hom xws li chemokines, interleukins, thiab interferons. | Chemokines yog cov proteins uas ua rau chemotaxis ntawm leukocytes. |
| feeb | |
| Cytokines tuaj yeem cuam tshuam ntau lub hlwb hauv lub cev. | Chemokines feem ntau cuam tshuam rau leukocytes thiab lymphocytes. |
| Txuag Cysteine Residues | |
| Txuag cysteine residues muaj nyob hauv cytokines. | Txhim kho cysteine residues tsis muaj nyob rau hauv chemokines. |
| Type | |
| Chemokines, Interleukins, Interferons yog hom cytokines. | C-C chemokines, C-X-C chemokines, C chemokines, CXXXC chemokines yog hom chemokines. |
| Function | |
| Mainly pro-inflammatory lossis anti-inflammatory. | Mainly inflammatory los yog homeostatic. |
Summary – Cytokines vs Chemokines
Cytokines thiab chemokines yog cov proteins me me uas muaj zog tiv thaiv kab mob. Chemokines koom nrog pawg loj ntawm cytokines tab sis tshwj xeeb ua haujlwm raws li chemotactic cytokine. Yog li ntawd, nws tsav lub activation ntawm leukocytes thiab nws migration mus rau lub hom phiaj. Cytokines thiab chemokines ua zoo ib yam li cov tshuaj hormones hauv kev ua rau muaj kev cuam tshuam los ntawm kev khi rau nws cov receptor. Qhov no tuaj yeem raug coj los ua qhov sib txawv ntawm Cytokines thiab Chemokines. Tam sim no; Ob leeg cov protein molecules no yog siv los ua biomarkers thaum ntxov los txheeb xyuas cov kab mob thiab tshuaj xyuas lub cev cov lus teb rau kev kho mob xws li atherosclerosis, ntshav qab zib, thiab kab mob.
Download the PDF Version of Cytokines vs Chemokines
Koj tuaj yeem rub tawm PDF version ntawm kab lus no thiab siv nws rau offline lub hom phiaj raws li daim ntawv ceeb toom. Thov download PDF version ntawm no Qhov txawv Ntawm Cytokines thiab Chemokines
