Qhov sib txawv tseem ceeb ntawm cov tshuaj tiv thaiv DNA thiab cov tshuaj tiv thaiv rov ua dua yog nyob ntawm kev npaj cov tshuaj tiv thaiv. Kev npaj tshuaj tiv thaiv DNA tshwm sim los ntawm kev siv cov noob xav tau lossis cov khoom tawg DNA, thaum cov tshuaj tiv thaiv rov ua dua yuav siv qhov chaw siv cov tshuaj tiv thaiv kab mob los yog cov vector uas muaj cov noob xav tau.
Cov tshuaj tiv thaiv tuaj yeem siv los ua cov kev kho mob prophylactic nrog rau cov tshuaj tiv thaiv kab mob. Muaj ntau hom kev txhaj tshuaj. DNA thiab cov tshuaj tiv thaiv sib xyaw ua ke yog cov qauv tshiab tshaj plaws. Ntxiv mus, cov tshuaj tiv thaiv no tseem tab tom tshawb fawb.
DNA Vaccine yog dab tsi?
DNA tshuaj tiv thaiv yog cov tshuaj tiv thaiv uas muaj DNA. Lawv muaj DNA uas code rau cov protein tshwj xeeb uas tuaj yeem tiv thaiv cov kab mob. Qhov zoo tshaj plaws, lawv yog code rau antigens uas ua rau cov kab mob ua kom lub cev tiv thaiv kab mob los yog ncaj qha rau cov tshuaj tiv thaiv kab mob tiv thaiv kab mob tshwj xeeb.
Tsis tas li ntawd, kev tswj hwm ntawm cov tshuaj tiv thaiv DNA tshwm sim los ntawm kev encapsulating DNA hauv cov neeg nqa khoom protein. Thaum nkag mus, nws yuav ncav cuag lub hom phiaj ntawm lub cev uas lawv yuav tshem tawm nws cov tshuaj ntsiav protein thiab tso tawm DNA. Tom qab ntawd, qhov DNA no yuav raug sau thiab txhais lus siv cov tswv cuab ntawm tes los ua kom muaj protein ntau.
Daim duab 01: Tshuaj Tiv Thaiv DNA
Txawm li cas los xij, FDA tseem tsis tau pom zoo cov tshuaj tiv thaiv DNA rau tib neeg siv. Tam sim no lawv tab tom sim. Cov tshuaj tiv thaiv DNA tau xav tias ua lub luag haujlwm tseem ceeb hauv kev kis kab mob.
Qhov zoo thiab qhov tsis zoo
cov tshuaj tiv thaiv DNA, uas yog cov tshuaj tiv thaiv thib peb, muaj txiaj ntsig zoo dua lwm cov tshuaj tiv thaiv raws li tau hais hauv qab no.
- Kev pheej hmoo kis tus kab mob tsawg kawg
- Kev nthuav qhia Antigen tuaj yeem ua tiav
- Easy to develop
- siab ruaj khov
- Long term persistence
Txawm li cas los xij, cov tshuaj tiv thaiv DNA kuj muaj qhov tsis zoo. Lawv qhia tau tias muaj peev xwm coj kev hloov pauv hauv tus tswv tsev DNA. Yog li, kev tshawb fawb dav dav yuav tsum tau ua ua ntej muab tshuaj tiv thaiv DNA rau tib neeg.
Yam tshuaj tiv thaiv kab mob sib kis yog dab tsi?
Kev txhaj tshuaj tiv thaiv rov ua dua yog nyob ntawm kev tswj hwm tus neeg sawv cev lom neeg rov ua dua tshiab raws li kev kho mob tiv thaiv kab mob. Nyob rau hauv txoj kev no, plasmid vectors, poov xab, bacteriophages, thiab adenoviruses feem ntau yog siv los ua recombinants xa cov protein uas xav tau rau tus tswv tsev tiv thaiv tus kab mob.
Daim duab 01: rVSV-ZEBOV - tshuaj tiv thaiv rov ua dua, rov ua dua-tshaj tawm
Ntxiv mus, recombinant DNA thev naus laus zis yog txheej txheem ntawm kev tswj cov noob nyob rau hauv vitro. Ib qho kev taw qhia ntawm cov noob txawv teb chaws rau hauv ib qho vector tshwm sim thawj zaug. Tom qab ntawd lub recombinant vector los yog recombinant molecule yuav tsum tau muab tso rau hauv lub hom phiaj kab mob. Thaum DNA nkag mus rau hauv, nws qhia thiab tsim cov khoom xav tau nyob rau hauv lub hom phiaj tus tswv tsev, uas tuaj yeem tawm tsam tus kab mob.
Dab tsi yog qhov zoo sib xws ntawm Cov Tshuaj Tiv Thaiv DNA thiab Cov Tshuaj Tiv Thaiv Rov Qab?
- tshuaj tiv thaiv DNA thiab tshuaj tiv thaiv rov ua dua yog ob qhov tshuaj tiv thaiv tshiab.
- Cov tshuaj tiv thaiv no koom nrog kev tswj hwm DNA cov kab ke ntawm cov noob rau tus tswv tsev.
- Lawv tau muab tso rau hauv cov hlab ntsha.
- Ob leeg yog cov tshuaj tiv thaiv thib peb.
- Tsis tas li ntawd, lawv tau cog lus ntau dua tiv thaiv kab mob kis.
- Ntxiv mus, ob txoj hauv kev yog qhov rhiab heev thiab tshwj xeeb.
Qhov txawv ntawm DNA Vaccine thiab Recombinant Vaccine yog dab tsi?
Qhov sib txawv tseem ceeb ntawm cov tshuaj tiv thaiv DNA thiab cov tshuaj tiv thaiv kab mob sib txuas yog tias cov tshuaj tiv thaiv DNA siv cov khoom tawg ntawm DNA, thaum cov tshuaj tiv thaiv recombinant siv cov vectors lossis cov kab mob sib kis los ua cov tshuaj tiv thaiv.
Hauv qab infographic qhia txog qhov sib txawv ntawm cov tshuaj tiv thaiv DNA thiab cov tshuaj tiv thaiv rov ua dua.
Summary – DNA Vaccine vs Recombinant Vaccine
Zuag qhia tag nrho, cov tshuaj tiv thaiv DNA thiab cov tshuaj tiv thaiv sib xyaw ua ke yog cov txheej txheem tshiab ntawm kev txhaj tshuaj. Cov tshuaj tiv thaiv DNA muaj cov seem ntawm DNA uas tuaj yeem sau cov proteins uas muaj peev xwm tiv thaiv kab mob. Piv txwv li, cov tshuaj tiv thaiv recombinant yog cov tshuaj tiv thaiv uas muaj cov kab mob sib kis los yog cov kab mob uas muaj cov noob xav tau. Cov recombinants no ces kis tus tswv tsev thiab tsim cov proteins uas xav tau. Tsis tas li ntawd, cov txheej txheem no muaj qhov tshwj xeeb thiab rhiab heev. Txawm li cas los xij, qhov kev pheej hmoo ntawm kev hloov pauv yog siab heev. Yog li ntawd, kev tshawb fawb thiab kev sim dav siv ua ntej kev pom zoo ntawm cov tshuaj tiv thaiv no. Yog li, qhov no qhia txog qhov sib txawv ntawm cov tshuaj tiv thaiv DNA thiab cov tshuaj tiv thaiv rov ua dua.
