Qhov sib txawv tseem ceeb ntawm glycation thiab glycosylation yog glycation tsis yog txheej txheem enzymatic thaum glycosylation yog txheej txheem enzymatic.
Ob leeg glycation thiab glycosylation yog ob txheej txheem uas ntxiv cov piam thaj molecules rau cov protein. Glycation yog cov txheej txheem tsis-enzymatic ntawm kev ntxiv cov suab thaj dawb rau cov protein covalently, uas tshwm sim nyob rau hauv cov hlab ntsha. Glycosylation, ntawm qhov tod tes, yog txheej txheem kev hloov pauv tom qab kev hloov pauv uas tshwm sim hauv endoplasmic reticulum thiab Golgi apparatus thaum tsim cov protein ua haujlwm. Txawm hais tias muaj qee qhov zoo sib xws ntawm glycation thiab glycosylation, kab lus no tham txog qhov sib txawv ntawm glycation thiab glycosylation.
YGlycation yog dab tsi?
Glycation yog txheej txheem tsis-enzymatic uas covalently ntxiv cov suab thaj dawb rau cov protein. Txij li nws tsis yog-enzymatic, glycation tshwm sim spontaneously hauv cov hlab ntsha. Yog li, txoj kev no tsis nyob rau hauv kev tswj ntawm ib qho enzyme. Glycation irreversibly ntxiv qab zib los yog qab zib degradative khoom rau cov proteins. Tsis tas li ntawd, glycation yog ib hom kev puas tsuaj rau cov protein. Yog li ntawd, nws txo qhov ruaj khov thiab ua haujlwm ntawm cov protein.
Daim duab 01: Glycation
Glucose, fructose lossis galactose yog cov suab thaj ntxiv thaum glycation. Los ntawm glycation, qhov sib ntxiv ntawm cov suab thaj tsuas yog siv qhov chaw hauv cov protein uas paub tab. Thawj kauj ruam ntawm glycation yog condensation. Nws yog cov txheej txheem siv sijhawm. Cov khoom kawg ntawm condensation yog ib qho tsis ruaj khov Shiff puag lossis aldimine. Tom qab ntawd, aldimine spontaneously rearranges los tsim cov khoom Amadori, uas yog ib qho ruaj khov keto amine. Tom qab ntawd, cov khoom no undergoes ntxiv degradation. Advanced glycation kawg cov khoom yog lub npe peb siv rau cov khoom kawg ntawm glycation.
YGlycosylation yog dab tsi?
Glycosylation yog txheej txheem kev hloov pauv tom qab kev hloov pauv uas tshwm sim hauv endoplasmic reticulum thiab Golgi apparatus. Tsis tas li ntawd, glycosylation pab txhawb kom muaj protein ntau folding thiab yog li txhawb kev ruaj ntseg ntawm cov protein. Li no, cov txheej txheem no tsim cov protein ua haujlwm raws li cov khoom kawg.
Ntxiv mus, qhov no yog txheej txheem tswj enzyme. Yog li, peb tuaj yeem txhais nws ua kev hloov kho enzymatic. Ntawm no, ib qho kev txiav txim siab ntawm cov piam thaj molecule yog ntxiv rau thaj tsam predefined ntawm cov protein. Cov kev cai ntawm cov txheej txheem no tshwm sim los ntawm kev tswj ntawm qhov kev txiav txim ntawm enzyme.
Daim duab 02: Glycosylation
Muaj ntau hom glycosylation. Lawv yog N-txuas glycosylation O-txuas glycosylation, phosphoserine glycosylation, thiab lwm yam. Feem ntau, thaum lub sij hawm glycosylation, carbonyl ib feem ntawm cov suab thaj reacts nrog amine los yog hydroxyl pab pawg neeg ntawm cov protein.
Dab tsi yog qhov zoo sib xws ntawm Glycation thiab Glycosylation?
- Ob leeg glycation thiab glycosylation ntxiv cov suab thaj rau cov proteins.
- Nyob rau hauv ob txoj kev, covalent bonds yog tsim los ntawm cov molecules.
- Ob leeg yog cov txheej txheem ntawm tes.
- Ntxiv mus, ob txoj haujlwm cuam tshuam rau kev ua haujlwm ntawm cov protein.
Qhov txawv ntawm Glycation thiab Glycosylation yog dab tsi?
Glycation yog txheej txheem tsis-enzymatic uas covalently ntxiv cov suab thaj dawb rau cov protein thaum glycosylation yog enzymatic tom qab kev hloov pauv cov txheej txheem tshwm sim hauv endoplasmic reticulum thiab Golgi apparatus, uas tsim cov protein ua haujlwm. Yog li, peb tuaj yeem txiav txim siab qhov no yog qhov sib txawv tseem ceeb ntawm glycation thiab glycosylation. Tsis tas li ntawd, glycation yog cov txheej txheem spontaneous; Yog li, nws tsis raug tswj los ntawm ib qho enzyme. Txawm li cas los xij, glycosylation yog cov txheej txheem enzyme tag nrho. Yog li, qhov no kuj yog qhov sib txawv ntawm glycation thiab glycosylation.
Ntxiv mus, glycation txo qhov ruaj khov thiab ua haujlwm ntawm cov protein. Txawm li cas los xij, glycosylation tsim cov protein ua haujlwm los ntawm kev ntxiv cov piam thaj molecules. Tsis tas li ntawd, qhov sib txawv ntxiv ntawm glycation thiab glycosylation yog tias glycation ntxiv qabzib, fructose lossis galactose rau cov proteins thaum glycosylation ntxiv xylose, fucose, mannose lossis glycans rau cov proteins. Qhov tseem ceeb tshaj plaws, glycosylation ua kom muaj protein ntau ruaj khov thaum glycation txo cov protein ruaj khov. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm glycation thiab glycosylation.
Cov hauv qab no nthuav tawm cov ntaub ntawv ntxiv txog qhov sib txawv ntawm glycation thiab glycosylation.
Summary – Glycation vs Glycosylation
Ob leeg glycation thiab glycosylation yog ob txheej txheem uas ntxiv qab zib rau cov protein. Glycation yog cov txheej txheem uas tsis yog-enzymatic uas tshwm sim hauv cov hlab ntsha. Hauv qhov sib piv, glycosylation yog cov txheej txheem enzyme-mediated uas tshwm sim hauv Golgi apparatus thiab endoplasmic reticulum nyob rau hauv kev hloov pauv tom qab kev hloov pauv. Tsis tas li ntawd, glycation txo qhov kev ruaj ntseg thiab kev ua haujlwm ntawm cov protein vim qhov sib ntxiv ntawm cov suab thaj thaum glycosylation hloov cov protein tsis paub qab hau rau hauv cov protein ua haujlwm vim yog ntxiv cov suab thaj. Yog li, qhov no yog cov ntsiab lus ntawm qhov sib txawv ntawm glycation thiab glycosylation.
