Qhov sib txawv tseem ceeb ntawm progenitor thiab precursor cells yog tias cov hlwb progenitor yog cov xeeb leej xeeb ntxwv ntawm cov qia hlwb uas tuaj yeem sib txawv los tsim ib lossis ntau hom hlwb thaum cov hlwb precursor yog cov hlwb tsis muaj qhov sib txawv uas muaj peev xwm sib txawv rau ntau hom. ntawm cov hlwb tshwj xeeb hauv lub cev.
Progenitor cells thiab precursor cells yog ob hom hlwb hauv lub cev uas muaj peev xwm sib txawv rau hauv cov cell tshwj xeeb hauv lub cev ntawm ntau cov kab mob. Txawm hais tias ob hom cell ua haujlwm zoo ib yam, lawv txawv ntawm ntau yam. Precursor cells ua ntej sib txawv rau hauv cov hlwb progenitor thiab tom qab ntawd sib txawv rau lwm hom cell ntawm lub cev. Li no, progenitor cells yog ib hom kab mob ua ntej.
Cov Progenitor Cells yog dab tsi?
Progenitor cells yog cov xeeb leej xeeb ntxwv ntawm cov qia hlwb uas tuaj yeem sib txawv los tsim ib lossis ntau hom hlwb. Lawv lub peev xwm rov ua dua nws tus kheej tsawg dua thaum nrog kev sib piv rau hauv cov hlwb ua ntej (stem cells). Nyob rau hauv cov ntsiab lus ntawm kev sib txawv ntawm tes, progenitor hlwb yog unipotent (differentiate mus rau hauv ib tug tshwj xeeb cell hom) los yog oligopotent (differentiating rau ob peb hom cell sib txawv).
Progenitor cells muaj peev xwm dhau mus dhau ntau qhov kev faib tawm ntawm tes hauv cov txheej txheem tsim ntau lub hlwb. Yog li ntawd, cov hlwb no tseem ceeb hauv cov txheej txheem hloov thiab kho cov ntaub so ntswg puas hauv lub cev. Yog li ntawd, progenitor cells muaj nyob nruab nrab ntawm cov qia hlwb thiab cov hlwb ua haujlwm loj hauv lub cev.
Daim duab 01: Progenitor Cells
Feem ntau, cov hlwb progenitor nyob hauv daim ntawv tsis muaj zog. Artificial sib txawv reagents los yog cytokines thiab kev loj hlob yam ua rau cov hlwb no. Thaum ua haujlwm, cov hlwb progenitor sib txawv rau hauv lawv cov hlwb tshwj xeeb thiab tseem tsiv mus rau qhov chaw sib txawv ntawm cov ntaub so ntswg.
Dab tsi yog Precursor Cells?
Precursor cells, hu ua qia hlwb, yog cov hlwb tsis muaj qhov sib txawv ntawm cov kab mob ntau yam. Cov hlwb precursor no muaj peev xwm ua kom sib txawv rau ntau hom hlwb. Raws li kev sib txawv ntawm tes, cov hlwb precursor tuaj yeem ua tau ntau lub zog, pluripotent thiab totipotent. Embryonic qia hlwb thiab cov neeg laus qia hlwb yog ob hom loj ntawm cov hlwb ua ntej.
Cov qia hlwb tsim nyob rau hauv 4-5 hnub qub embryo thaum lub sij hawm blastocyst ntawm lub embryonic kev loj hlob. Tom qab ntawd los ntawm embryoblast, cov neeg laus cov kabmob ntawm lub cev tuaj. Cov neeg laus qia hlwb muaj nyob hauv cov pob txha, ntshav, hlwb, daim siab, cov leeg pob txha, thiab daim tawv nqaij.
Daim duab 02: Precursor Cells
Ntau yam kev raug mob ntawm cov ntaub so ntswg thiab kab mob ua rau cov neeg laus qia hlwb sib txawv thiab nthuav dav. Thaum lawv induced, ces tsuas yog cov cell sib txawv mus rau hauv tshwj xeeb hlwb nyob rau hauv ib tug tej ntaub so ntswg. Yog li ntawd, lawv raug xa mus rau cov ntaub so ntswg tshwj xeeb qia hlwb. Sib nrug los ntawm embryonic thiab cov neeg laus qia hlwb, fetal qia hlwb, mesenchymal qia hlwb, thiab induced pluripotent qia hlwb yog lwm hom precursor hlwb hauv lub cev.
Dab tsi yog qhov zoo sib xws ntawm Progenitor thiab Precursor Cells?
- Ob leeg progenitor thiab precursor hlwb muaj peev xwm sib txawv rau hauv cov cell tshwj xeeb hauv lub cev ntawm ntau cov kab mob.
- Tsis tas li, ob qho tib si raug ntxias los ntawm kev loj hlob thiab cytokines.
Qhov txawv ntawm Progenitor thiab Precursor Cells yog dab tsi?
Cov hlwb Progenitor thiab cov hlwb precursor tuaj yeem sib txawv rau hauv cov hlwb tshwj xeeb hauv cov ntaub so ntswg. Txawm li cas los xij, cov hlwb progenitor yog cov xeeb leej xeeb ntxwv ntawm cov qia hlwb lossis cov hlwb ua ntej. Yog li ntawd, lawv yog cov hlwb sib txawv me ntsis. Ntawm qhov tod tes, cov hlwb precursor yog tag nrho undifferentiated. Yog li, nws yog qhov sib txawv tseem ceeb ntawm progenitor thiab precursor cells. Tsis tas li ntawd, cov hlwb progenitor yog unipotent lossis oligopotent thaum lub hlwb precursor tuaj yeem ua tau ntau lub zog, pluripotent thiab totipotent. Li no, nws kuj yog qhov sib txawv ntawm progenitor thiab precursor cells. Myeloid progenitor cells, lymphoid progenitor cells, neural progenitor cells, blast cells, thiab pancreatic progenitor cells yog cov piv txwv ntawm cov hlwb progenitor thaum cov blastocysts, umbilical cord blood, thiab pob txha pob txha yog cov piv txwv ntawm cov qia hlwb.
Hauv qab infographic ntawm qhov sib txawv ntawm progenitor thiab precursor hlwb piav txog qhov sib txawv no piv.
Summary – Progenitor vs Precursor Cells
Ob leeg progenitor thiab precursor hlwb muaj peev xwm sib txawv rau hauv cov cell tshwj xeeb hauv lub cev ntawm ntau cov kab mob. Progenitor hlwb yog unipotent los yog oligopotent thaum lub hlwb precursor yuav ua tau multipotent, pluripotent thiab totipotent. Qhov sib txawv tseem ceeb ntawm progenitor thiab precursor hlwb yog cov hlwb progenitor yog cov xeeb leej xeeb ntxwv ntawm cov qia hlwb uas tuaj yeem sib txawv los tsim ib lossis ntau hom hlwb thaum cov hlwb precursor yog cov hlwb tsis muaj qhov sib txawv uas muaj peev xwm sib txawv rau ntau hom hlwb tshwj xeeb hauv lub cev.. Cov kev loj hlob thiab cytokines induce ob hom cell. Qhov no qhia txog qhov sib txawv ntawm progenitor thiab precursor hlwb.
