Qhov sib txawv tseem ceeb ntawm BRCA1 thiab BRCA2 kev hloov pauv yog qhov kev hloov pauv ntawm cov noob caj noob ces ntawm BRCA1 noob (BReast Cancer genes 1), uas nyob hauv chromosome 17, yog BRCA1 kev hloov pauv thaum hloov pauv hauv cov noob caj noob ces. BRCA2 gene (BReast Cancer genes 2), uas muaj nyob rau hauv chromosome 13, yog BRCA2 mutation.
BRCA1 thiab BRCA2 (BReast Cancer genes 1 thiab 2) yog ob hom noob uas paub zoo cuam tshuam nrog kev pheej hmoo ntawm mob qog noj ntshav mis. Yog li ntawd, thaum lawv ua hauj lwm ib txwm, ob lub noob code rau qog suppressor proteins. Cov qog nqaij hlav qog nqaij hlav pab cov hlwb los kho DNA puas zoo thiab ua kom cov hlwb muaj kev nyab xeeb. Cov kab lis kev cai ntawm cov noob no tuaj yeem hloov pauv, yog li, ua rau muaj kev hloov pauv. Ntau tshaj 100 BRCA kev hloov pauv tau raug txheeb xyuas txog tam sim no. Qee qhov kev hloov pauv tsis ua rau muaj kev pheej hmoo rau kev noj qab haus huv thaum ob peb tsim cov qog nqaij hlav ntawm lub mis thiab zes qe menyuam hauv cov poj niam. Tsis tas li ntawd, BRCA kev hloov pauv tuaj yeem ua rau muaj kev pheej hmoo ntawm ntau yam qog nqaij hlav xws li mob qog noj ntshav, mob qog noj ntshav, thiab mob qog noj ntshav, thiab lwm yam.
BRCA1 Mutation yog dab tsi?
BRCA1 noob yog ib qho ntawm cov qog nqaij hlav cancer mis txuas cov noob nyob hauv chromosome 17. Thaum cov noob caj noob ces ntawm BRCA1 hloov pauv, nws yog hu ua BRCA1 kev hloov pauv. BRCA1 kev hloov pauv ua rau mob qog noj ntshav, thiab lawv feem ntau yog triple tsis zoo. Cov kev hloov pauv no nyuaj rau kho vim lawv tsis teb zoo rau cov tshuaj hormonal.
Daim duab 01: BRCA Genes
Tsis tas li ntawd, thaum BRCA1 hloov pauv, nws ua rau muaj kev pheej hmoo mob qog nqaij hlav zes qe menyuam los ntawm hnub nyoog 70 xyoo hauv 54% rau cov poj niam. BRCA1 kev hloov pauv tau txais los ntawm niam txiv. Txawm li cas los xij, lawv tuaj yeem tau txais thiab. Thaum sib piv BRCA1 thiab BRCA2 kev hloov pauv, BRCA1 kev hloov pauv ntau dua.
BRCA2 Mutation yog dab tsi?
BRCA2 noob muaj nyob rau hauv chromosome 13. Thaum cov noob caj noob ces ntawm cov noob no hloov, nws yog kev hloov ntawm BRCA2. BRCA2 kev hloov pauv ua rau mob qog noj ntshav mis, thiab lawv muaj tsawg dua li BRCA1 kev hloov pauv.
Ntxiv mus, cov tshuaj hormonal tuaj yeem kho cov kev hloov pauv no. Qhov kev pheej hmoo ntawm kev tsim qog nqaij hlav zes qe menyuam thaum muaj hnub nyoog 70 yog 27% ntawm cov poj niam uas muaj BRCA2 kev hloov pauv.
Qhov Zoo sib xws ntawm BRCA1 thiab BRCA2 Kev Hloov Pauv yog dab tsi?
- Ob leeg BRCA1 thiab BRCA2 kev hloov pauv muaj kev pheej hmoo tsim mob qog noj ntshav hauv cov poj niam.
- Cov kev hloov pauv no tuaj yeem ua tau rau lwm tiam.
- BRCA1 thiab BRCA2 kev hloov pauv tsis tshua muaj nyob hauv cov pej xeem.
- Ob qho kev hloov pauv ua rau muaj kev pheej hmoo ntawm qog nqaij hlav zes qe menyuam thiab.
Qhov txawv ntawm BRCA1 thiab BRCA2 Kev Hloov Pauv yog dab tsi?
BRCA1 thiab BRCA2 yog ob lub noob uas cuam tshuam nrog qog nqaij hlav ntawm lub mis thiab zes qe menyuam. Thaum lawv cov kab lis kev cai hloov pauv, peb hu nws ua BRCA1 kev hloov pauv thiab BRCA2 kev hloov pauv feem. Tsis tas li ntawd, BRCA1 kev hloov pauv ntau dua li BRCA2 kev hloov pauv. Cov ntaub ntawv hauv qab no qhia cov ntsiab lus ntxiv ntawm qhov sib txawv ntawm BRCA1 thiab BRCA2 kev hloov pauv.
Summary – BRCA1 vs BRCA2 Mutation
BRCA1 thiab BRCA2 kev hloov pauv tshwm sim thaum cov gene sequences ntawm ob lub noob hloov. Cov kev hloov pauv no muaj peev xwm ua rau mob qog noj ntshav mis thiab zes qe menyuam. Lawv tsis tshua muaj neeg nyob hauv ib txwm muaj. Piv rau BRCA2 kev hloov pauv, BRCA1 kev hloov pauv ntau dua, thiab lawv feem ntau yog triple tsis zoo. Qhov no yog qhov txawv ntawm BRCA1 thiab BRCA2 kev hloov pauv.
