Qhov sib txawv tseem ceeb ntawm beta lactam thiab non beta lactam yog tias cov tshuaj tua kab mob beta lactam muaj lub nplhaib beta lactam hauv lawv cov qauv molecular thaum cov tshuaj tua kab mob uas tsis yog beta lactam tsis muaj beta lactam nplhaib hauv lawv cov qauv molecular.
Tshuaj tua kab mob yog tshuaj tua kab mob uas tiv thaiv kab mob. Muaj ntau hom tshuaj tua kab mob. Cov tshuaj no revolutionized cov tshuaj. Qee cov tshuaj tua kab mob tua cov kab mob muaj zog thaum qee qhov inhibit qhov kev loj hlob thiab kev loj hlob ntawm cov kab mob. Txawm li cas los xij, cov kab mob tau txais tshuaj tua kab mob vim lawv siv ntau dhau thiab nkag tau yooj yim. Cov tshuaj tua kab mob beta lactam thiab cov tshuaj tsis yog beta lactam yog ob hom tshuaj tua kab mob loj.
Beta Lactam yog dab tsi?
tshuaj tua kab mob beta lactam yog cov tshuaj tua kab mob uas muaj beta lactam nplhaib hauv lawv cov qauv. Lawv muaj nitrogen molecule txuas nrog beta carbon. Lawv yog cov tshuaj tua kab mob broad-spectrum xws li penicillin derivatives, cephalosporins, monobactams, carbapenems, thiab lwm yam. Cov tshuaj tua kab mob no inhibit biosynthesis ntawm cov phab ntsa ntawm tes thiab ua rau cov kab mob ua kom puas.
Daim duab 01: Beta Lactam Antibiotics
Lawv siv siab piv rau lwm yam tshuaj tua kab mob. Txawm li cas los xij, cov kab mob tau tsim tshuaj tua kab mob tiv thaiv cov tshuaj tua kab mob beta lactam. Lub enzyme hu ua beta lactamase tau muab lawv cov kev tiv thaiv ntau rau beta lactam tshuaj tua kab mob. Yog li, txhawm rau kov yeej qhov teeb meem no, cov kws kho mob tau sau tshuaj beta lactamase inhibitors nrog tshuaj tua kab mob beta lactam. Cov tshuaj tua kab mob beta lactam muaj zog dua tiv thaiv cov kab mob zoo. Txawm li cas los xij, tshuaj tua kab mob beta lactam tuaj yeem siv rau cov kab mob gram-tsis zoo ib yam nkaus.
Non Beta Lactam yog dab tsi?
Tsis yog beta lactam tshuaj tua kab mob yog cov tshuaj lossis tshuaj tua kab mob uas tsis muaj beta lactam nplhaib hauv lawv cov qauv molecular. Cov tshuaj tua kab mob no muaj zog tsawg dua li cov tshuaj tua kab mob beta lactam. Lawv txoj kev siv tau pom cov txiaj ntsig tsis zoo. Cov kws tshawb fawb xav tias qhov no yog vim qhov ntau dua ntawm kev kho tsis zoo empiric hauv pawg tsis yog beta lactam. Vancomycin yog ib hom tshuaj tua kab mob uas tsis yog beta lactam, uas muaj cov qauv molecular complex heev. Fosfomycin thiab bacitracin yog ob qho piv txwv ntawm cov tshuaj tua kab mob uas tsis yog beta lactam. Daptomycin yog lwm yam tshuaj tua kab mob uas tsis yog beta lactam, uas yog lipopeptide. Chloramphenicol yog ib qho tshuaj tua kab mob bacteriostatic, uas yog tsis yog beta lactam.
Daim duab 02: Tsis yog Beta Lactam Antibiotic - Vancomycin
Qee cov kws tshawb fawb tau hais tias qhov ua tau zoo ntawm cov tshuaj tua kab mob uas tsis yog beta lactam tuaj yeem txhim kho thaum lawv siv cov tshuaj tua kab mob beta lactam xws li penicillin, thiab lwm yam. Nws yog vim tias, thaum lawv nyob ua ke, lawv pom muaj kev sib koom ua ke ntawm cov kab mob..
Dab tsi zoo sib xws ntawm Beta Lactam thiab Non Beta Lactam?
- ob leeg yog tshuaj tua kab mob uas ua haujlwm tiv thaiv kab mob.
- Cov tshuaj no tuaj yeem tua lossis inhibit qhov kev loj hlob ntawm cov kab mob.
Qhov txawv ntawm Beta Lactam thiab Non Beta Lactam yog dab tsi?
Beta lactam thiab non beta lactam tshuaj tua kab mob yog ob hom tshuaj tua kab mob uas tau sau tseg los tiv thaiv kab mob. Cov tshuaj tua kab mob beta lactam muaj lub nplhaib beta lactam hauv lawv cov qauv thaum cov tshuaj tua kab mob uas tsis yog beta lactam tsis muaj lub nplhaib. Qhov no yog qhov sib txawv tseem ceeb ntawm beta lactam thiab tsis yog beta lactam tshuaj tua kab mob. Ntxiv mus, cov tshuaj tua kab mob beta lactam muaj qhov dav dav thiab muaj zog dua li cov tshuaj tua kab mob uas tsis yog beta lactam.
Summary – Beta Lactam vs Non Beta Lactam
Tshuaj tua kab mob yog cov tshuaj uas siv los tiv thaiv kab mob. Lawv tuaj yeem yog bactericidal lossis bacteriostatic. Cov tshuaj tua kab mob tua cov kab mob thaum cov tshuaj tua kab mob bacteriostatic inhibit lossis ntes cov kab mob loj hlob. Cov tshuaj tua kab mob beta lactam thiab cov tshuaj tsis yog beta lactam tshuaj tua kab mob muaj ob hom, ntawm lawv, tshuaj tua kab mob beta lactam muaj zog dua thiab dav dua li cov tshuaj tsis yog beta lactam. Muaj lub nplhaib beta lactam nyob rau hauv cov qauv molecular ntawm beta lactam tshuaj tua kab mob thaum nws tsis muaj nyob rau hauv cov tshuaj uas tsis yog beta lactam tshuaj tua kab mob. Qhov no yog qhov sib txawv ntawm beta lactam thiab non beta lactam tshuaj tua kab mob.
