Qhov sib txawv tseem ceeb ntawm acetyl CoA thiab acyl CoA yog tias acetyl CoA (los yog acetyl Coenzyme A) pab hauv cov protein, carbohydrate, thiab lipid metabolism thaum acyl CoA (lossis acyl Coenzyme A) pab hauv cov metabolism ntawm fatty acids.
Acetyl CoA muaj txiaj ntsig zoo hauv kev xa cov acetyl pawg rau Krebs lub voj voog rau kev tsim hluav taws xob. Ib pawg acetyl yog ib pab pawg ua haujlwm uas muaj cov tshuaj formula -C(O)CH3 Ib pawg acyl kuj yog ib pab pawg ua haujlwm muaj cov tshuaj formula -C(O)R qhov twg pawg R yog fatty acid side chain. Nws muaj txiaj ntsig zoo hauv kev tsim hluav taws xob los ntawm kev hloov mus rau acetyl CoA.
Acetyl CoA yog dab tsi?
Acetyl CoA lossis acetyl Coenzyme A yog ib qho tseem ceeb molecule koom nrog hauv cov metabolism ntawm cov proteins, carbohydrates, thiab lipids. Nws muaj txiaj ntsig zoo hauv kev xa cov acetyl ua haujlwm rau lub voj voog Krebs rau kev tsim hluav taws xob. Nyob ntawd, cov acetyl CoA oxidizes, ua ATP.
Daim duab 1: Cov qauv dav dav ntawm Acetyl CoA
Acetyl CoA cov ntaub ntawv los ntawm kev sib xyaw ntawm ntau cov amino acids, pyruvate, thiab fatty acids. Acetylating CoA muab acetyl CoA, thiab qhov no tshwm sim ntawm glycolysis ntawm carbohydrates thiab beta-oxidation ntawm fatty acids. Cov molecule no muaj thioester txuas uas yog reactive heev vim nws cov ntsiab lus siab zog. Yog li ntawd, hydrolysis ntawm thioester daim ntawv cog lus yog exergonic (uas txhais tau tias, nws tso tawm lub zog rau ib puag ncig).
Tom qab acetyl CoA nkag mus rau lub voj voog Krebs, nws oxidizes rau carbon dioxide (CO2) thiab dej (H2O). Thiab qhov no oxidation tso tawm lub zog, uas yog tom qab ntawd ntes raws li ATP thiab GTP molecules. Ib qho acetyl CoA pab tsim 11 ATP thiab ib GTP.
Acyl CoA yog dab tsi?
Acyl CoA yog ib qho tseem ceeb molecule siv hauv fatty acid metabolism. Nws yog ib pawg ntawm coenzymes. Cov tshuaj no muaj ib coenzyme A txuas rau cov roj fatty acids. Nws yog ib qho kev sib xyaw ib ntus uas yooj yim tawg rau hauv Coenzyme thiab fatty acid.
Daim duab 2: Cov qauv dav dav ntawm Acyl CoA
Acyl CoA compound tseem ceeb heev hauv kev tsim cov tsiaj txhu vim nws hloov mus rau acetyl CoA thiab, nkag mus rau Krebs voj voog los tsim ATP thiab GTP. Lub beta-oxidation ntawm acyl CoA tsim acetyl CoA.
Thaum tsim cov acyl CoA molecule, fatty acid dhau los ua ob-kauj ruam cov tshuaj tiv thaiv rau kev ua kom cov fatty acid. Acyl-CoA synthetase catalyzes cov tshuaj tiv thaiv no. Hauv thawj kauj ruam, fatty acid displaces diphosphate pawg ntawm ATP molecule (Ib qho ATP molecule yog triphosphate molecule) thiab yog li, tsim AMP (adenosine monophosphate). Hauv kauj ruam thib ob, coenzyme A tshem tawm AMP ib feem ntawm cov molecule los ua acyl CoA.
Qhov txawv ntawm Acetyl CoA thiab Acyl CoA yog dab tsi?
Acetyl CoA vs Acyl CoA |
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| Acetyl CoA yog ib qho tseem ceeb molecule koom nrog hauv cov metabolism ntawm cov proteins, carbohydrates, thiab lipids. | Acyl CoA yog ib qho tseem ceeb molecule siv hauv fatty acid metabolism. |
| Role hauv Metabolism | |
| Pab hauv cov metabolism ntawm cov proteins, carbohydrates, thiab lipids. | Pab hauv cov metabolism ntawm fatty acids. |
| Reaction Mechanism | |
| Nkag mus rau lub voj voog Krebs los tsim ATP thiab GTP. | Hloov mus rau acetyl CoA, uas tig mus, nkag mus rau Krebs Cycle los tsim ATP thiab GTP. |
| Form los ntawm kev sib xyaw ntawm ntau cov amino acids, pyruvate, thiab fatty acids. | Forms los ntawm ob-kauj ruam cov tshuaj tiv thaiv nrog fatty acid (rau kev ua kom cov fatty acid). |
Summary – Acetyl CoA vs Acyl CoA
Acetyl CoA thiab acyl CoA yog cov qauv ntawm coenzymes. Cov no yog cov molecules tseem ceeb heev nyob rau hauv cov metabolism ntawm cov tshuaj lom neeg sib txawv. Qhov sib txawv tseem ceeb ntawm acetyl CoA thiab acyl CoA yog tias acetyl CoA pab hauv cov protein, carbohydrate, thiab lipid metabolism whereas, acyl CoA pab hauv cov metabolism ntawm fatty acids.
