Qhov sib txawv tseem ceeb ntawm Somatic thiab Germline Gene Therapy nyob ntawm seb hom hlwb siv los ua cov noob kho. Somatic Gene therapy yog hais txog kev taw qhia lossis kev hloov pauv ntawm cov noob hauv cov hlwb somatic. Germline Gene therapy yog hais txog kev qhia lossis hloov cov noob hauv cov kab mob.
Gene therapy tam sim no yog ib qho kev kho mob yav tom ntej raws li nws lub hom phiaj ua rau tus kab mob. Los ntawm kev hloov cov noob ua lub luag haujlwm rau ib qho kab mob tshwj xeeb, nws muaj peev xwm tshem tawm tus kab mob thaum ntxov. Yog li ntawd, txoj kev kho noob tau qhia cov txheej txheem tshiab hauv kev kho kab mob thiab tshem tawm cov kab mob.
Somatic Gene Therapy yog dab tsi?
Somatic Gene therapy yog hais txog hom kev kho noob uas cov noob muaj nyob hauv cov hlwb somatic hloov kho kom kho tus kab mob. Cov noob caj noob ces raug tshuaj xyuas kom pom cov noob hloov pauv lossis tsis zoo. Li no, txoj kev kho no siv cov thev naus laus zis Antisense, uas ntsiag to cov noob tsis raug lossis qhia cov noob noj qab haus huv los ntawm cov txheej txheem hloov pauv.
Muaj ob hom kev kho noob somatic; ex vivo thiab vivo. Ex vivo somatic gene therapy koom nrog kev tshem tawm cov hlwb tawm ntawm lub cev, thaum hauv vivo somatic gene therapy tshwm sim thaum cov hlwb nyob hauv lub cev.
Daim duab 01: Somatic Gene Therapy
Somatic hlwb tsis yog kev sib deev. Yog li ntawd, tsis muaj kev txhawj xeeb txog kev coj ncaj ncees hauv txoj hauv kev no. Somatic gene therapy muaj feem xyuam rau cystic fibrosis, muscular dystrophy, thiab qee yam kab mob sib kis.
Germline Gene Therapy yog dab tsi?
Germline Gene Therapy yog ib hom kev kho noob tshwj xeeb uas cov noob muaj nyob hauv cov kab mob hauv cov kab mob vim nws tuaj yeem hloov cov phev hlwb ntawm cov txiv neej thiab qe qe ntawm poj niam. Germline therapy ua rau theem fetal siv karyotyping txhawm rau txheeb xyuas cov noob tsis zoo uas muaj nyob hauv tus menyuam hauv plab. Raws li kev txheeb xyuas cov noob tsis raug, tshem tawm, hloov pauv thiab qhia cov noob tshiab tuaj yeem ua tau.
Vim qhov kev kho no hloov cov kab mob, thaum kawg lawv cov kev hloov pauv hloov mus rau tiam tom ntej thiab yog li rov tsim dua. Yog li ntawd, nws yog ib qho tsim nyog yuav tsum tau soj ntsuam ntau yam kev coj ncaj ncees ua ntej txoj kev kho germline noob. Germline gene therapy yog pab tau rau cov kab mob caj ces xws li ADA deficiency, PNP deficiency thiab Lesch – Nyan Syndrome, thiab lwm yam.
Dab tsi yog qhov zoo sib xws ntawm Somatic thiab Germline Gene Therapy?
- Ob qho tib si Somatic thiab Germline Gene kev kho mob koom nrog kev hloov pauv cov noob tsis raug lossis qhia cov noob noj qab haus huv.
- Ob txoj kev kho mob siv cov kev hloov pauv noob.
Qhov txawv ntawm Somatic thiab Germline Gene Therapy yog dab tsi?
Somatic vs Germline Gene Therapy |
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| Somatic Gene therapy yog hais txog kev hloov pauv ntawm genome ntawm somatic hlwb los ntawm kev hloov kho cov noob caj noob ces. | Germline Gene therapy yog hais txog kev hloov pauv ntawm cov genome ntawm cov kab mob ntawm tes los ntawm kev qhia cov noob tshuaj kho. |
| Hom Cells koom nrog | |
| Somatic noob therapy siv Somatic hlwb. | Germline gene therapy siv cov kab mob xws li phev hlwb thiab qe qe. |
| Kev hloov pauv ua los ntawm kev kho cov noob noob caj noob ces tsis yog rov tsim dua. Yog li no, txhob hla dhau mus rau tiam tom ntej. | Kev hloov pauv ua los ntawm kev kho cov noob caj noob ces yog rov tsim dua. Li no, hla mus rau tiam tom ntej. |
| Kev hloov pauv txoj hauv kev | |
| Techniques siv nyob rau hauv somatic noob kho yog qhov yooj yim. Li no, tuaj yeem ua tau raws li hauv vitro. | Techniques complex vim nws muaj cov qauv fetal. |
| Teeb meem kev ncaj ncees koom nrog | |
| Tsawg los yog tsis muaj teeb meem kev coj ncaj ncees muaj txog kev kho cov noob caj noob ces. | Kev xav txog kev coj ncaj ncees muaj nyob rau hauv kev kho cov noob caj noob ces. |
| kev sib hlub | |
| Somatic gene therapy yog kev saib xyuas ntau dua. | Germline gene therapy is less conservative. |
Summary – Somatic vs Germline Gene Therapy
Kev kho noob caj ces cuam tshuam nrog kev hloov pauv ntawm cov noob, tshem tawm cov noob tsis zoo, lossis qhia cov noob noj qab haus huv raws li txoj hauv kev kho cov kab mob caj ces thiab kab mob. Somatic Gene Therapy yog Gene therapy ua rau cov hlwb somatic uas tsis muaj menyuam yaus thaum Germline gene therapy yog kev kho cov noob ua rau cov kab mob uas muaj menyuam yaus. Qhov no yog qhov txawv ntawm Somatic gene therapy thiab germline gene therapy.
