Qhov Tseem Ceeb - Lipoprotein Lipase vs Hormone Sensitive Lipase
Lipases yog enzymes uas hydrolyze lipids. Txhawm rau nkag mus rau hauv cov hlab ntsha, lipids yuav tsum tau hydrolyzed rau hauv fatty acids thiab glycerol. Lipoprotein lipase (LPL) nyob rau hauv ib qho enzyme uas yog ib tug tswv cuab ntawm lipase noob tsev neeg thiab activates los ntawm insulin. Hormone-sensitive lipase (HSL) yog ib qho enzyme koom nrog hauv hydrolysis ntawm esters tshwj xeeb tshaj yog cov cholesterol esters thiab tau qhib los ntawm glucagon thiab cov tshuaj hormones kev ntxhov siab. Qhov sib txawv tseem ceeb yog qhov ua kom muaj zog ntawm ob lub enzymes. Lipoprotein lipase (LPL) yog qhib los ntawm cov tshuaj insulin thaum cov tshuaj hormone-sensitive lipase (HSL) yog qhib los ntawm cov tshuaj hormones kev ntxhov siab (glucagon thiab lwm yam.).
YLipoprotein Lipase yog dab tsi?
Lipoprotein lipase (LPL) yog suav tias yog ib tug tswv cuab ntawm tsev neeg ntawm lipase. Cov lipases muaj xws li hepatic lipase, endothelial lipase, thiab pancreatic lipase. LPL yog tsim los ntawm ob thaj chaw tshwj xeeb uas yog, qhov loj dua N-terminus thiab me C-terminus domain. Qhov loj N-terminus domain muaj lipolytic active site. Ib tus peptide linker pab ob lub npe no los txuas ua ke. N-terminus yog cov qauv globular uas muaj cov ntawv hauv nruab nrab ntawm Beta uas tau muab kaw los ntawm helices. Lub C-terminus siv cov duab ntawm lub tog raj kheej elongated thiab yog Beta sandwich ua los ntawm ob txheej ntawm cov nplooj ntawv Beta.
Lipoprotein lipases feem ntau yog dej-soluble enzymes uas ua haujlwm rau hydrolyze triglycerides hauv lipoproteins. Lawv kuj koom nrog hauv kev txhawb nqa cellular uptake ntawm cov roj cholesterol-nplua nuj lipoproteins, chylomicron remnants, thiab dawb fatty acids. LPL tau txuas mus rau luminal nto ntawm endothelial hlwb uas muaj nyob rau hauv capillaries. Qhov txuas ntawm cov enzyme no yog tshwm sim los ntawm heparin sulfated proteoglycans thiab cov protein glycosylphosphatidylinositol HDL-binding protein 1 (GPIHBP1). LPL yog dav dav hauv lub plawv, cov nqaij pob txha, thiab adipose thiab nrog rau cov qog mammary uas raug lactation.
Daim duab 01: Lipoprotein Lipase
LPL feem ntau yog tswj hwm kev hloov pauv thiab tom qab hloov pauv. Lub luag haujlwm ntawm cov LPL no yog los pab hauv kev encoding lipoprotein lipases uas muaj nyob rau ntawm cov hlwb endothelial hauv cov leeg, lub plawv thiab cov ntaub so ntswg adipose. Nws kuj ua raws li homodimer. Nws tuaj yeem ua tus catalyst los pab hloov VLDL rau IDL thiab tom qab ntawd rau LDL. Yog tias muaj kev hloov pauv loj uas tau tshwm sim, nws ua rau LPL tsis txaus uas ua rau hom I hyperlipoproteinemia. Tab sis, yog tias muaj kev hloov pauv uas tsis loj heev ces nws yuav ua rau muaj kev cuam tshuam ntawm lipoprotein metabolism.
Hormone Sensitive Lipase yog dab tsi?
Hormone-sensitive lipase (HSL) yog hu ua enzyme uas koom nrog hauv hydrolysis ntawm esters. Nws yog ib qho intracellular nruab nrab lipase uas tseem raug xa mus los ntawm lo lus cholesteryl ester hydrolase yav dhau los. HSL tuaj yeem yog ob daim ntawv, daim ntawv ntev thiab luv. Ob daim ntawv yog nthuav tawm nyob rau hauv ntau hom ntaub so ntswg. HSL yog qhia nyob rau hauv cov ntaub so ntswg steroidogenic xws li testis nyob rau hauv daim ntawv ntev. Nws ua haujlwm hauv kev hloov pauv ntawm cov cholesterol esters rau hauv cov cholesterol dawb. Qhov no ua rau kev tsim cov tshuaj steroid hormones. HSL yog qhia nyob rau hauv cov ntaub so ntswg adipose nyob rau hauv ntev hom uas koom nyob rau hauv lub hydrolysis ntawm triglycerides rau fatty acids.
Thaum lub sijhawm xav tau siab rau lub zog ntawm lub cev, HSL tau qhib kom txhawb nqa cov rog. Kev ua kom HSL ua haujlwm nyob rau hauv ob kauj ruam nrog kev koom tes ntawm ob lub tshuab sib txawv. Thaum pib, HSL tau txav mus rau hauv qhov chaw ntawm lipid molecule los ntawm phosphorylated periphilin A uas ua raws li hydrolysis ntawm lipid molecule.
Daim duab 02: Cov txheej txheem ntawm lipolysis thiab HSL ua haujlwm
Thib ob, HSL tau qhib rau hauv cov txheej txheem tsis tseem ceeb piv rau thawj zaug. Ntawm no HSL tau txais kev ua haujlwm los ntawm txoj kev taw qhia los ntawm ib qho tshwj xeeb molecule hu ua cAMP-dependent protein kinase A (PKA). Qhov kev ua kom muaj zog no yog qhov tseem ceeb hauv kev tsim cov lipids uas tshwm sim hauv kev teb rau cyclic AMP (cAMP). CAMP ntau lawm yog nce nrog kev ua kom muaj Gprotein-coupled receptor. Txoj kev thib ob ntawm HSL ua kom tshwm sim tshwm sim hauv glucagon receptor thiab ACTH receptor los ntawm kev txhawb nqa ntawm beta-adrenergic thiab ACTH feem. HSL koom nrog hauv kev nthuav tawm cov rog uas khaws cia. Qhov no suav hais tias yog lub luag haujlwm tseem ceeb ntawm HSL. Qhov enzyme no hydrolyzes triacylglycerol thiab diacylglycerol ua rau tso cov roj fatty acid ntawm txhua qhov piv txwv nrog kev tsim cov diglyceride thiab monoglyceride raws li.
Dab tsi yog qhov zoo sib xws ntawm Lipoprotein Lipase thiab Hormone Sensitive Lipase?
Ob leeg koom nrog cov tshuaj tiv thaiv hydrolysis
Qhov txawv ntawm Lipoprotein Lipase thiab Hormone Sensitive Lipase yog dab tsi?
Lipoprotein Lipase vs Hormone Sensitive Lipase |
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| Lipoprotein lipase (LPL) yog suav tias yog ib tug tswv cuab ntawm tsev neeg ntawm lipase. Cov lipases muaj xws li hepatic lipase, endothelial lipase, thiab pancreatic lipase. | Immunogen yog ib qho txawv teb chaws molecule lossis ib hom antigen uas tuaj yeem ua rau lub cev tiv thaiv kab mob los ntawm kev ua rau lub cev tiv thaiv kab mob. |
| Kev ua haujlwm | |
| LPL yog qhib los ntawm Insulin thiab Apolipoprotein C II. | HSL yog qhib los ntawm Catecholamines thiab glucagon. |
Summary – Lipoprotein Lipase vs Hormone Sensitive Lipase
LPL thiab HSL yog cov enzymes tseem ceeb txhawm rau tswj thiab tswj cov roj metabolism hauv lub siab, cov ntaub so ntswg adipose, thiab cov hnyuv. Lawv koom nrog hauv cov tshuaj tiv thaiv hydrolytic. LPL ua nyob rau hauv lub xeev pub thaum muaj rog muaj ntau thiab coj cov rog kom hydrolyzed khaws cia. HSL ua haujlwm hauv lub xeev yoo mov txhawm rau txhawm rau txhawm rau cov khw muag roj kom tsim cov roj fatty acids dawb rau kev tsim hluav taws xob. Yog li, qhov tsis txaus ntawm cov enzymes no tuaj yeem ua rau muaj kev tsis sib haum xeeb hauv cov roj metabolism.
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