Qhov Tseem Ceeb - Aplastic Anemia vs Leukemia
Leukemia tuaj yeem txhais tau tias yog qhov sib txuam ntawm cov qog ntshav dawb monoclonal txawv txav hauv cov pob txha. Los ntawm lub npe nws tus kheej, koj tuaj yeem nkag siab tias leukemia yog hom malignancy. Pancytopenia nrog hypercellularity (aplasia) ntawm cov pob txha pob txha raug txheeb xyuas tias yog aplastic anemia. Qhov sib txawv tseem ceeb ntawm aplastic anemia thiab leukemia yog qhov muaj lossis tsis muaj cov qog nqaij hlav cancer, leukemic, lossis cov hlwb txawv txav; leukemia yog tus cwj pwm los ntawm qhov muaj cov qog nqaij hlav, leukemic lossis cov hlwb txawv txav hauv cov ntshav peripheral lossis pob txha pob txha thaum aplastic anemia tsis yog.
Aplastic Anemia yog dab tsi?
Pancytopenia nrog hypercellularity (aplasia) ntawm cov pob txha pob txha tuaj yeem txhais tau tias yog aplastic anemia. Hauv qhov xwm txheej no, tsis muaj leukemic, mob qog noj ntshav lossis lwm cov hlwb txawv txav tsis pom nyob rau hauv cov ntshav peripheral lossis pob txha pob txha. Kev txo qis ntawm cov pluripotent qia hlwb ua ke nrog qhov tsis xws luag hauv qhov seem lossis kev tiv thaiv kab mob tsis zoo tiv thaiv lawv tuaj yeem ua rau aplastic anemia. Cov mob no tuaj yeem hloov mus rau hauv myelodysplasia, paroxysmal nocturnal hemoglobinuria lossis AML hauv qee kis.
Etiology
Immune mechanisms ua lub luag haujlwm tseem ceeb hauv feem ntau ntawm cov xwm txheej. Cov pob txha pob txha tsis ua haujlwm yog tshwm sim los ntawm cov kab mob cytotoxic T hlwb hauv cov ntshav thiab cov pob txha pob txha. Cov pob txha pob txha aplasia tuaj yeem tshwm sim vim yog cov tshuaj cytotoxic xws li busulfan thiab doxorubicin. Tab sis qee cov tshuaj uas tsis yog-cytotoxic xws li chloramphenicol, kub, carbimazole, chlorpromazine, phenytoin, ribavirin, tolbutamide, thiab NSAIDs kuj muaj peev xwm ua rau aplasia hauv qee tus neeg.
Daim duab 01: Aplastic Anemia hauv pob txha pob txha
Tshuaj Kho Mob
- Anemia
- Kab mob
- Ecchymoses
- Cov pos hniav los ntshav thiab epistaxis
x
Kev tshawb nrhiav
- ntshav suav-Hemoglobin txo qis
- Ntshav zaj duab xis-Tsis muaj cov hlwb txawv txav, Reticulocyte suav qis heev, Platelets me me.
Kev tswj hwm
Kev kho mob ntawm aplastic anemia nyob ntawm qhov tshwm sim. Ua tib zoo mloog yuav tsum tau muab rau kev txhawb nqa kev kho mob thaum tos cov pob txha pob txha rov qab. Kev txhawb nqa kev kho mob suav nrog RBC kev hloov pauv, kev hloov ntshav platelet, thiab kev hloov pauv granulocyte. Kev tiv thaiv kab mob sai yog qhov tseem ceeb heev. Rau cov neeg mob uas muaj mob hnyav aplastic anemia hnub nyoog qis dua 40 xyoo, kev kho mob xaiv yog hemopoietic qia hlwb.
Leukemia yog dab tsi?
Leukemia tuaj yeem txhais tau tias yog qhov sib txuam ntawm cov qog ntshav dawb monoclonal txawv txav hauv cov pob txha. Qhov no ua rau cov pob txha tsis ua haujlwm, ua rau mob ntshav qab zib, neutropenia, thiab thrombocytopenia. Feem ntau, qhov feem pua ntawm cov hlwb tawg hauv cov pob txha neeg laus yog tsawg dua 5%. Tab sis nyob rau hauv cov pob txha leukemic, qhov kev faib ua feem ntau tshaj 20%.
Type
Muaj 4 hom kab mob leukemia li,
- Acute myeloid leukemia (AML)
- Tus mob lymphoblastic leukemia (TAG NRHO)
- Chronic myeloid leukemia (AML)
- Chronic lymphocytic leukemia (CLL)
Cov kab mob no tsis tshua muaj tshwm sim thiab qhov tshwm sim txhua xyoo yog 10/1000000. Feem ntau, leukemia tuaj yeem tshwm sim txhua lub hnub nyoog. Tab sis TAG NRHO feem ntau pom hauv cov menyuam yaus thaum CLL nquag tshwm sim hauv cov neeg laus. Cov kab mob etiological ua rau mob leukemia muaj xws li hluav taws xob, kab mob, cov kab mob cytotoxic, kev tiv thaiv kab mob thiab cov caj ces. Kev kuaj mob ntawm tus kab mob tuaj yeem ua tiav los ntawm kev kuaj xyuas cov kab mob ntawm cov ntshav peripheral thiab cov pob txha pob txha. Rau kev faib tawm thiab kev soj ntsuam, kev tiv thaiv kab mob, cytogenetics, thiab molecular noob caj noob ces yog qhov tseem ceeb.
Daim duab 02: Leukemia
mob leukemia
Qhov tshwm sim ntawm tus mob leukemia nce ntxiv nrog rau hnub nyoog dhau los. Lub hnub nyoog nruab nrab ntawm kev nthuav qhia rau mob myeloblastic leukemia yog 65 xyoo. Mob leukemia tej zaum yuav tshwm sim de novo los yog vim ua ntej cytotoxic chemotherapy los yog myelodysplasia. Mob lymphoblastic leukemia muaj hnub nyoog qis dua qhov kev nthuav qhia. Nws yog qhov mob hnyav tshaj plaws hauv menyuam yaus.
kho mob nta ntawm TXHUA
- Ua tsis taus pa thiab qaug zog
- Kab mob
- Headache/confuse
- pob txha
- YHepatosplenomegaly/lymphadenopathy
- Testicular o
x
Kev kho mob ntawm AML
- Gum hypertrophy
- Ntxhais tawv nqaij tawv
- qaug zog thiab ua tsis taus pa
- Kab mob
- YHepatosplenomegaly
- YLymphadenopathy
x
Kev tshawb nrhiav
Rau Kev Pom Zoo Txog Kev Tshawb Fawb
- Ntshav suav-Platelets thiab hemoglobin feem ntau qis, cov ntshav dawb suav ib txwm sawv.
- Ntshav zaj duab xis-Lineage ntawm tus kab mob tuaj yeem txheeb xyuas tau los ntawm kev soj ntsuam cov hlwb tawg. Auer rods tuaj yeem pom hauv AML.
- pob txha pob txha aspiration-Txo erythropoiesis, txo megakaryocytes, thiab nce cellularity yog cov cim los nrhiav.
- lub hauv siab X-ray
- Cerebrospinal kua tshuaj
- Txoj kev sib txuas profile
For Planning Therapy
- Serum urate thiab siab biochemistry
- Electrocardiography/echocardiogram
- HLA type
- Kuaj HBV xwm txheej
Kev tswj hwm
Tsis kho mob leukemia feem ntau tuag taus. Tab sis nrog kev kho mob palliative, lub neej ntev tuaj yeem txuas ntxiv. Kev kho mob qee zaum tuaj yeem ua tiav. Kev ua tsis tiav tuaj yeem yog vim muaj tus kab mob rov qab los yog vim muaj teeb meem ntawm kev kho mob lossis vim yog qhov tsis zoo ntawm tus kab mob. Nyob rau hauv tag nrho, remission induction tuaj yeem ua tiav nrog kev sib xyaw ua ke ntawm kev kho mob ntawm Vincristine. Rau cov neeg mob uas muaj kev pheej hmoo siab, kev hloov pauv ntawm cov qia cell tuaj yeem ua tau.
Chronic Myeloid Leukemia
CML yog ib tug tswv cuab ntawm tsev neeg ntawm myeloproliferative neoplasms uas tsuas yog tshwm sim rau cov neeg laus. Nws yog txhais los ntawm lub xub ntiag ntawm Philadelphia chromosome thiab muaj kev kawm qeeb qeeb dua li mob qog noj ntshav.
Tshuaj Kho Mob
- Symptomatic anemia
- mob plab tsis xis nyob
- poob qis
- Headache
- YLymphadenopathy
Kev tshawb nrhiav
- ntshav suav - Hemoglobin qis lossis ib txwm muaj. Platelets yog qis, zoo li qub lossis tsa. WBC tau tsa.
- Kev muaj tus paub tab myeloid precursors hauv ntshav zaj duab xis
- Kev nce cellularity nrog nce myeloid precursors hauv pob txha pob txha aspirate.
Kev tswj hwm
Thawj kab tshuaj hauv kev kho mob ntawm CML yog Imatinib (Glivec), uas yog tyrosine kinase inhibitor. Cov kab mob thib ob suav nrog kev siv tshuaj khomob nrog hydroxyurea, alpha interferon, thiab kev hloov pauv ntawm cov qia hlwb allogeneic.
Chronic Lymphocytic Leukemia
CLL yog cov kab mob qog ntshav ntau tshaj plaws uas feem ntau tshwm sim thaum laus. Nws yog tshwm sim los ntawm clonal expansion ntawm me B lymphocytes.
Tshuaj Kho Mob
- Asymptomatic lymphocytosis
- YLymphadenopathy
- Marrow tsis ua haujlwm
- YHepatosplenomegaly
- B-symptoms
Kev tshawb nrhiav
- Cov qe ntshav dawb siab heev tuaj yeem pom hauv cov ntshav suav
- Smudge cells tuaj yeem pom hauv cov ntshav zaj duab xis
Kev tswj hwm
Kev kho yog muab rau cov teeb meem organomegaly, ntu hemolytic, thiab pob txha pob txha. Rituximab ua ke nrog Fludarabine thiab cyclophosphamide qhia cov lus teb zoo heev.
Qhov Zoo sib xws ntawm Aplastic Anemia thiab Leukemia yog dab tsi?
Aplastic Anemia thiab Leukemia yog hematological mob
Qhov txawv ntawm Aplastic Anemia thiab Leukemia yog dab tsi?
Aplastic Anemia vs Leukemia |
|
| Leukemia tuaj yeem txhais tau tias yog qhov sib txuam ntawm cov qog ntshav dawb monoclonal txawv txav hauv cov pob txha. | Pancytopenia nrog hypercellularity (aplasia) ntawm cov pob txha pob txha tuaj yeem txhais tau tias yog aplastic anemia. |
| Kab tsis zoo | |
| Cov hlwb tsis zoo muaj nyob hauv cov ntshav thiab cov pob txha. | Cov hlwb tsis zoo tsis pom nyob rau hauv cov ntshav lossis cov pob txha. |
| Qhov no yog qhov phem. | Ntawm no tsis yog kev phem. |
Summary – Aplastic Anemia vs Leukemia
Leukemia yog qhov sib txuam ntawm qhov txawv txav ntawm cov qe ntshav dawb monoclonal hauv cov pob txha thaum aplastic anemia yog pancytopenia nrog hypercellularity ntawm cov pob txha pob txha. Qhov no yog qhov sib txawv ntawm aplastic anemia thiab leukemia. Kev kuaj mob ntxov thiab kev kho mob ntawm ob qho xwm txheej no tseem ceeb heev kom tsis txhob muaj teeb meem kev ua neej.
Download PDF Version of Aplastic Anemia vs Leukemia
Koj tuaj yeem rub tawm PDF version ntawm kab lus no thiab siv nws rau offline hom phiaj raws li daim ntawv ceeb toom. Thov download PDF version ntawm no Qhov txawv Ntawm Aplastic Anemia thiab Leukemia.
