Qhov Tseem Ceeb Qhov txawv - Wernicke Encephalopathy vs Korsakoff Syndrome
Wernicke encephalopathy yog tshwm sim los ntawm thiamine deficiency thiab yog tus cwj pwm los ntawm cov tsos mob ntawm kev puas siab puas ntsws thiab ophthalmoplegia. Cov mob no tuaj yeem thim rov qab los ntawm thiamine supplementation. Tab sis yog tias tsis kho, Wernicke encephalopathy tuaj yeem nce mus rau theem tsis tuaj yeem hu ua Korsakoff syndrome. Yog li, lawv yog ob sab ntawm ib qho spectrum ntawm kev kho mob tshwm sim. Qhov sib txawv tseem ceeb ntawm Wernicke Encephalopathy thiab Korsakoff Syndrome yog tias Wernicke encephalopathy yog thim rov qab thaum Korsakoff syndrome tsis tuaj yeem rov qab los.
Wernicke Encephalopathy yog dab tsi?
Raws li tau hais dhau los, thiamine (vitamin B1) tsis txaus yog qhov ua rau Wernicke encephalopathy. Tus mob no feem ntau cuam tshuam nrog kev haus dej cawv ntev ntev vim yog cawv ntawm cov metabolism hauv thiamine. Nws tau raug tsim los hais tias kev haus dej cawv ntev ntev tuaj yeem txo cov plab hnyuv nqus ntawm thiamine li ntawm 70%. Tsis tas li ntawd, qee qhov ua rau tsis muaj cawv xws li gastric carcinomas, ntuav ntuav, thiab mob plab kuj tuaj yeem ua rau Wernicke encephalopathy. Qee tus neeg mob uas muaj kab mob hauv lub raum kawg tuaj yeem ua rau hemodialysis ua rau thiamine deficiency.
Muaj kev xav tsis thoob txog kev sib raug zoo ntawm kev phais mob bariatric thiab Wernicke encephalopathy. Feem coob ntawm cov kws kho mob ntseeg tias qhov kev phais tshwj xeeb no tau ua los tiv thaiv kev rog rog ua rau Wernicke encephalopathy. Qhov tsis txaus thiamine loj heev uas tau pom nyob rau hauv cov neeg coob coob uas tau txais kev phais bariatric yog tam sim no lees paub tias yog "Bariatric beriberi".
Kev tshaib kev nqhis yog lwm qhov laj thawj tseem ceeb ntawm qhov teeb meem neural, tshwj xeeb tshaj yog nyob rau hauv cov teb chaws tsim. HIV/AIDS, plawv tsis ua hauj lwm thiab thyrotoxicosis kuj tuaj yeem ua rau tus mob no.
Pathophysiology
Thiamine yog ib qho tseem ceeb ntawm cov vitamin uas ua haujlwm ua cofactor rau ntau lub enzymes xws li pyruvate dehydrogenase thiab transketolase, uas koom nrog hauv kev ua pa aerobic. Peb lub paj hlwb muaj qhov xav tau ntau heev thiab lub zog rau cov txheej txheem metabolic no tshwm sim hauv lub hlwb los ntawm kev ua pa aerobic. Thaum cov qib thiamine hauv lub cev tsis txaus, qhov kev tsim hluav taws xob no ua tsis tiav, ua rau cov ntaub so ntswg tuag thiab cov tsos mob tshwm sim tom qab.
Morphology
Qhov tshwj xeeb pom hauv Wernicke encephalopathy yog qhov muaj foci ntawm hemorrhage thiab necrosis. Cov no yog pom feem ntau nyob rau hauv lub cev mammillary thiab nyob rau hauv cov phab ntsa ntawm peb thiab plaub ventricles. Thaum xub thawj, cov capillaries yog dilated thiab muaj cov kab mob endothelial loj. Nws thiaj li, nrog rau tus kab mob mus zuj zus, cov capillaries rupture tsim ib lub zos micro hemorrhages.
Symptoms
- Kev tsis sib haum
- Kev puas tsuaj ntawm kev txawj ntse
- Ataxia
- Ophthalmoplegia
Kev tshawb nrhiav
Cov kev tshawb nrhiav hauv qab no tuaj yeem ua tiav los ntsuas kev noj zaub mov zoo ntawm tus neeg mob.
- YSerum vitamin B1
- YSerum albumin
- Kev ua haujlwm Transketolase hauv cov qe ntshav liab
MRI scan ntawm lub hlwb yog ua los ntsuas qhov kev puas tsuaj rau lub paj hlwb neural.
Daim duab 01: MRI Kev Tshawb Fawb ntawm tus neeg mob Wernicke Encephalopathy
Kev kho mob
- Thiamine supplementation
- Kev hloov pauv kev noj haus
- Kev txo qis kev haus cawv
Korsakoff Syndrome yog dab tsi?
Korsakoff syndrome yog ib qho kev puas siab puas ntsws uas tsis tuaj yeem tshwm sim los ntawm kev cuam tshuam ntawm lub sij hawm luv luv thiab kev sib txuas lus. Ntev tsis kho thiamine deficiency yog lub hauv paus rau tus mob no; Yog li ntawd, ib qho ntawm cov ua rau Wernicke encephalopathy tuaj yeem ua rau Korsakoff syndrome kuj.
Daim duab 02: Kev haus dej cawv yog ib qho ua rau Korasakoff syndrome.
Morphology
Cov cheeb tsam hemorrhagic tsim thaum lub sijhawm pib (Wernicke encephalopathy theem) raug cuam tshuam los ntawm macrophages. Cov kab mob scavenger no rhuav tshem cov ntaub so ntswg puas hauv cov cheeb tsam uas tsim cov cystic qhov chaw uas muaj hemosiderin laden macrophages.
Symptoms
- Tsis muaj peev xwm nco qab cov xwm txheej tsis ntev los no
- Long term memory gaps
- Kev sib tw
- Txoj kev nyuaj hauv kev kawm cov ntaub ntawv tshiab
Kev kho mob
Tsis muaj kev kho mob rau Korsakoff syndrome. Kev tswj cov tsos mob yog ua los txhawm rau txhim kho tus txheej txheem ntawm kev ua neej nyob ntawm tus neeg mob.
- Thiamine supplementation
- Kev hloov pauv lub neej
- Txhob siv cawv
Dab tsi zoo sib xws ntawm Wernicke Encephalopathy thiab Korsakoff Syndrome?
- Thiamine deficiency yog lub hauv paus rau ob qho tib si.
- Txhua yam uas ua rau muaj qhov tsis txaus thiamine tuaj yeem ua rau Wernicke encephalopathy lossis Korsakoff syndrome.
- Cawv yog qhov ua rau muaj qhov tshwm sim ntau tshaj plaws.
Qhov txawv ntawm Wernicke Encephalopathy thiab Korsakoff Syndrome yog dab tsi?
Wernicke Encephalopathy vs Korsakoff Syndrome |
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| Wernicke encephalopathy yog ib qho kev puas siab puas ntsws uas tshwm sim los ntawm cov tsos mob ntawm kev puas siab puas ntsws thiab ophthalmoplegia. | Korsakoff Syndrome yog tus cwj pwm los ntawm kev sib txuas lus thiab kev nco lub sijhawm luv luv. |
| Kev hloov pauv | |
| Thiamine supplementation tuaj yeem thim rov qab Wernicke encephalopathy. | Korsakoff Syndrome yog irreversible. |
| Ntse | |
| Qhov chaw ntawm necrosis thiab micro hemorrhages tuaj yeem pom. | Ntxiv rau thaj chaw ntawm necrosis thiab hemorrhage, cystic qhov chaw nrog hemosiderin laden macrophages muaj. |
Summary – Wernicke Encephalopathy vs Korsakoff Syndrome
Ob leeg Wernicke encephalopathy thiab Korsakoff syndrome yog tshwm sim los ntawm thiamine deficiency thiab cawv yog qhov ua rau ob qho tib si no. Qhov sib txawv tseem ceeb ntawm Wernicke encephalopathy thiab Korsakoff syndrome yog tias Wernicke encephalopathy yog thim rov qab nrog thiamine supplementation whereas Korsakoff syndrome yog irreversible. Ob leeg Wernicke encephalopathy thiab Korsakoff syndrome tuaj yeem tiv thaiv tau yooj yim los ntawm kev txo qis kev haus cawv. Dej cawv yeej tsis tau raug suav hais tias yog ib qho zoo los ntawm kws kho mob thiab ob qho kev mob no yog cov piv txwv txaus ntshai vim li cas kev haus cawv ntau dhau yuav tsum poob siab.
Download PDF Version of Wernicke Encephalopathy vs Korsakoff Syndrome
Koj tuaj yeem rub tawm PDF version ntawm kab lus no thiab siv nws rau offline hom phiaj raws li daim ntawv ceeb toom. Thov download PDF version ntawm no Qhov txawv Ntawm Wernicke Encephalopathy thiab Korsakoff Syndrome.
