Qhov sib txawv tseem ceeb ntawm NAC thiab glutathione yog NAC yog qhov ua ntej rau glutathione tam sim ntawd, qhov glutathione yog cov tshuaj antioxidant uas muaj nyob hauv cov nroj tsuag, tsiaj txhu, fungi, kab mob, thiab qee qhov archaea.
N-acetylcysteine lossis NAC yog ib hom acetylcysteine , thiab nws raug txwv tsis pub siv hauv tshuaj. Glutathione yog ib qho antioxidant compound uas muaj nyob rau hauv cov nroj tsuag, tsiaj txhu, fungi, kab mob, thiab ib co archaea.
NAC yog dab tsi?
N-acetylcysteine lossis NAC yog ib hom acetylcysteine. Nws los ntawm cov amino acid L-cysteine . Muaj ntau yam kev siv NAC thiab nws tau pom zoo los ntawm FDA ua tshuaj. Txawm hais tias qee qhov kev noj zaub mov muaj N-acetylcysteine , raws li US FDA cov lus qhia, nws tsis raug cai rau cov khoom noj kom muaj cov khoom no. Qhov no yog vim N-acetylcysteine yog ib qho tshuaj pom zoo. Tab sis koj tuaj yeem tau txais cov tshuaj N-acetyl cysteine cov khoom hauv qab kev taw qhia ntawm cov kws kho mob.
Figure 01: NAC
Raws li cov tshuaj noj, cov tshuaj no yog siv los ntawm kws kho mob los kho acetaminophen overdose, thiab nws kuj tuaj yeem pab ua kom cov hnoos qeev hauv cov neeg muaj mob ntsws. Tsis tas li ntawd, NAC yog ib qho tseem ceeb tshaj plaws rau cov khoom muaj nqi heev hu ua glutathione. Nrog rau cov amino acids glutamine thiab glycine, NAC yuav tsum tau ua thiab ntxiv glutathione.
Peb tuaj yeem nce qib cellular ntawm glutathione los ntawm kev noj NAC. Tom qab ntawd NAC tau nqus los ntawm lub plab zom mov, thiab nws kuj tso tawm cysteine rau hauv cov hlab ntsha.
YGlutathione yog dab tsi?
Glutathione tuaj yeem txhais tau tias yog cov tshuaj tiv thaiv antioxidant uas muaj nyob hauv cov nroj tsuag, tsiaj txhu, fungi, kab mob, thiab qee qhov archaea. L Glutathione yog cov isomer tshaj plaws ntawm glutathione; yog li ntawd, nws feem ntau hu ua glutathione. Cov tshuaj no tuaj yeem tiv thaiv kev puas tsuaj rau cov khoom tseem ceeb ntawm tes, uas yog tshwm sim los ntawm cov pa oxygen reactive, nrog rau cov dawb radicals, peroxides, lipid peroxides, thiab qee cov hlau hnyav.
Daim duab 02: Cov Qauv Tshuaj ntawm Glutathione
Thaum xav txog cov qauv tshuaj ntawm L-glutathione, nws yog ib qho tripeptide compound uas muaj gamma peptide txuas ntawm cysteine thiab carboxyl pawg (hauv glutamate sab saw). Nws yog dawb do soluble nyob rau hauv dej thiab insoluble nyob rau hauv cov organic solvents xws li methanol thiab diethyl ether.
Muaj ob kauj ruam ntawm biosynthesis ntawm L-glutathione. Thawj kauj ruam suav nrog kev sib txuas ntawm gamma-glutamylcysteine los ntawm L-glutamate thiab cysteine . Cov kauj ruam thib ob suav nrog qhov sib ntxiv ntawm C-terminal ntawm gamma-glutamylcysteine catalyzed los ntawm glutathione synthetase.
Raws li antioxidant, nws tuaj yeem tiv thaiv cov hlwb los ntawm kev ua kom tsis muaj zog ntawm cov pa oxygen. Tsis tas li ntawd, nws tuaj yeem koom nrog hauv kev tiv thaiv thiol thiab redox kev cai hauv cellular thiol proteins (nyob rau hauv lub xub ntiag ntawm oxidative kev nyuaj siab). Ntxiv mus, glutathione koom nrog ntau cov tshuaj tiv thaiv metabolic, suav nrog biosynthesis ntawm leukotrienes thiab prostaglandins.
Qhov txawv ntawm NAC thiab Glutathione yog dab tsi?
NAC thiab glutathione yog cov qauv tshuaj lom neeg. Qhov sib txawv tseem ceeb ntawm NAC thiab glutathione yog NAC yog qhov ua ntej rau glutathione tam sim ntawd, qhov glutathione yog cov tshuaj tiv thaiv antioxidant uas muaj nyob hauv cov nroj tsuag, tsiaj txhu, fungi, kab mob, thiab qee qhov archaea..
Hauv qab no yog cov ntsiab lus ntawm qhov sib txawv ntawm NAC thiab glutathione hauv daim ntawv tabular rau ib sab ntawm kev sib piv.
Summary – NAC vs Glutathione
N-acetylcysteine lossis NAC yog ib hom acetylcysteine , thiab nws raug txwv tsis pub siv hauv tshuaj. Glutathione tuaj yeem txhais tau tias yog cov tshuaj tiv thaiv antioxidant uas muaj nyob hauv cov nroj tsuag, tsiaj txhu, fungi, kab mob, thiab qee qhov archaea. Qhov sib txawv tseem ceeb ntawm NAC thiab glutathione yog NAC yog qhov ua ntej rau glutathione tam sim ntawd, qhov glutathione yog cov tshuaj tiv thaiv antioxidant uas muaj nyob hauv cov nroj tsuag, tsiaj txhu, fungi, kab mob, thiab qee qhov archaea..
