Qhov sib txawv tseem ceeb ntawm amphotericin B thiab liposomal amphotericin B yog tias amphotericin B yog cov tshuaj tiv thaiv kab mob uas muaj cov tshuaj amphotericin B deoxycholate, thaum liposomal amphotericin B yog cov tshuaj tua kab mob uas muaj cov tshuaj tua kab mob uas muaj cov tshuaj tiv thaiv kab mob uas muaj amphotericin B deoxycholate. ntawm phosphhatidylcholine, cholesterol, thiab distearoyl phosphatidylglycerol nyob rau hauv aqueous media uas muaj amphotericin B.
Tshuaj tua kab mob yog siv los kho cov kab mob fungal uas feem ntau cuam tshuam rau ntawm daim tawv nqaij, plaub hau, thiab rau tes. Cov kab mob fungal uas tau kho nrog tshuaj tua kab mob muaj xws li cov kab mob ringworm, kis las ko taw, fungal ntsia thawv kab mob, qhov chaw mos thrush, thiab thrush. Amphotericin B thiab liposomal amphotericin B yog ob hom tshuaj tiv thaiv kab mob. Txawm li cas los xij, qee cov kab mob fungal xws li aspergillosis, uas cuam tshuam rau lub ntsws, thiab cov kab mob fungal, uas cuam tshuam rau lub hlwb, yuav tsum tau kho hauv tsev kho mob.
Amphotericin B yog dab tsi?
Amphotericin B yog tshuaj tua kab mob uas muaj cov tshuaj amphotericin B deoxycholate. Amphotericin B yog siv los kho cov kab mob fungal hauv cov neeg mob neutropenic, crptococcal meningitis hauv kab mob HIV, kab mob fungal, thiab leishmaniasis. Cov txheej txheem qub no siv sodium deoxycholate, uas txhim kho nws cov solubility. Amphotericin B deoxycholate (ABD) yog siv rau intravenously. Raws li tus thawj formulation ntawm amphotericin B, nws yog feem ntau hu ua pa amphotericin B.
Daim duab 01: Amphotericin B
Amphotericin B exerts nws cov nyhuv antifungal los ntawm kev cuam tshuam cov synthesis ntawm cell phab ntsa ntawm fungi los ntawm kev khi rau cov sterols. Qhov no ua rau kev tsim cov pores nyob rau hauv lub cell phab ntsa, uas tso cai rau xau ntawm cellular Cheebtsam. Tsis tas li ntawd, amphotericin B deoxycholate tau ua tus qauv kub rau kev kho mob ntawm cov kab mob fungal rau 40 xyoo dhau los. Vim yog lub raum toxicity ntawm cov pa Amphotericin B, kev tshawb fawb dav tau coj mus rau kev txhim kho ntawm ntau cov tshuaj tua kab mob tshiab, suav nrog cov tshuaj lipid ntawm amphotericin B, board spectrum azoles, thiab echinocandins.
Liposomal Amphotericin B yog dab tsi?
Liposomal amphotericin B yog cov tshuaj tiv thaiv kab mob uas muaj cov kab mob unilamellar liposomal vesicle ua los ntawm kev sib xyaw ntawm phosphhatidylcholine, cholesterol, thiab distearoyl phosphatidylglycerol nyob rau hauv aqueous media uas muaj amphotericin B. Qhov kev txiav txim siab lipid no tau tsim los txhim kho. tolerability thiab txo toxicity. Yog li, liposomal formulations muaj tsawg lub raum toxicity tshaj amphotericin B deoxycholate. Tsis tas li ntawd, liposomal amphotericin B muaj tsawg dua cov tshuaj tiv thaiv kab mob. Txawm li cas los xij, liposomal amphotericin B yog kim dua li cov pa amphotericin B. Cov tshuaj tua kab mob no tuaj yeem siv los kho cov kab mob fungal, cryptococcal meningitis, visceral leishmaniasis, Candida auris fungemia, thiab histoplasmosis.
Daim duab 02: Liposomal Amphotericin B
AmBisome (LAMB) yog liposomal formulation ntawm amphotericin B uas ib txwm qhia los ntawm kev txhaj tshuaj. Tsis tas li ntawd, nws yog Ameslikas tsim los ntawm Nexstar Pharmaceuticals thiab pom zoo los ntawm FDA hauv 1997. Liposomal amphotericin B yog lag luam los ntawm Gllead hauv Tebchaws Europe thiab tau tso cai rau Astellas Pharma rau kev lag luam hauv Tebchaws Meskas thiab Sumitomo Pharmaceuticals hauv Nyiv.
Dab tsi yog qhov zoo sib xws ntawm Amphotericin B thiab Liposomal Amphotericin B?
- Amphotericin B thiab liposomal amphotericin B yog ob hom tshuaj tiv thaiv kab mob.
- Ob hom tshuaj tiv thaiv kab mob muaj amphotericin B ua cov tshuaj tiv thaiv kab mob tseem ceeb.
- Lawv tau qhia rau tus neeg mob txhaj tshuaj.
- Ob hom tshuaj tiv thaiv kab mob muaj tib lub tswv yim: cuam tshuam kev sib txuas ntawm cov phab ntsa ntawm tes ntawm fungi los ntawm kev khi rau cov sterols.
Qhov txawv ntawm Amphotericin B thiab Liposomal Amphotericin B yog dab tsi?
Amphotericin B (thawj) yog cov tshuaj tiv thaiv kab mob uas muaj cov tshuaj amphotericin B deoxycholate, thaum liposomal amphotericin B yog cov tshuaj tiv thaiv kab mob uas muaj cov liposomal vesicle unilamellar uas ua los ntawm kev sib xyaw ntawm phosphatidylcholine, cholesterol, thiab phosphatidylcholine. nyob rau hauv aqueous media uas muaj amphotericin B. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm amphotericin B thiab liposomal amphotericin B. Tsis tas li ntawd, amphotericin B muaj kev tiv thaiv tsawg thiab muaj tshuaj lom ntau dua liposomal amphotericin B.
Cov duab hauv qab no nthuav tawm qhov sib txawv ntawm amphotericin B thiab liposomal amphotericin B hauv daim ntawv tabular rau ib sab kev sib piv.
Summary – Amphotericin B vs Liposomal Amphotericin B
Amphotericin B thiab liposomal amphotericin B yog ob hom tshuaj tiv thaiv kab mob siv los kho cov kab mob fungal uas ib txwm cuam tshuam rau ntawm daim tawv nqaij, plaub hau, thiab rau tes. Amphotericin B Amphotericin B Amphotericin B deoxycholate cov tshuaj, thaum liposomal amphotericin B muaj ib lub unilamellar liposomal vesicle ua los ntawm kev sib xyaw ntawm phosphhatidylcholine, cholesterol, thiab distearoyl phosphatidylglycerol hauv cov xov xwm aqueous uas muaj amphotericin B yog qhov sib txawv ntawm qhov no, yog li qhov sib txawv ntawm amphotericin B. thiab liposomal amphotericin B.
