Qhov sib txawv tseem ceeb ntawm cov rog soluble thiab dej soluble statins yog cov roj-soluble statins tuaj yeem nkag mus rau hauv cov hlwb thiab cuam tshuam nrog cov cell membranes, qhov dej-soluble statins qhia tau tias muaj ntau dua hepatoselectivity thiab tsis tuaj yeem nkag mus rau cov hlwb yooj yim.
Statins yog ib pawg ntawm cov tshuaj uas tuaj yeem ua kom txo qis cov roj cholesterol hauv cov ntshav. Hauv lwm lo lus, cov no yog cov tshuaj noj uas muaj txiaj ntsig zoo hauv kev txo qis cov roj cholesterol hauv cov tib neeg uas muaj kab mob plawv atherosclerotic lossis cov neeg muaj kev pheej hmoo ntawm kev tsim kab mob atherosclerotic. Cov tshuaj no tuaj yeem thaiv kev tsim cov cholesterol hauv daim siab. Muaj ob hom rog-soluble statins (lipophilic statins) thiab dej-soluble statins (hydrophilic statins). Raws li qee qhov kev tshawb fawb, hydrophilic statins muaj txiaj ntsig zoo piv rau lipophilic statins.
YFat Soluble Statins yog dab tsi?
Fat-soluble statins lossis lipophilic statins yog hom tshuaj uas soluble hauv lipids. Kev nqus ntawm hom tshuaj no yog qhov sib piv sai dua vim tias lawv tuaj yeem yaj hauv lipids thiab nkag mus rau hauv cell membranes yooj yim. Fat-soluble statins yog sawv cev los ntawm cov tshuaj uas tsis yog-ionized lossis nonpolar. Lub raum tsis zoo lim ionized molecules, tab sis cov rog-soluble statins feem ntau reabsorbed rov qab rau hauv tubule. Nyob ntawd, feem ntau ntawm cov rog-soluble tshuaj yog metabolized rau hauv polar metabolites uas yog dej-soluble.
Daim duab 1: Kev nqus cov khoom noj thiab lwm yam khoom xyaw rau hauv cov ntshav
Dab tsi yog Dej Soluble Statins?
Dej-soluble statins lossis hydrophilic statins yog hom tshuaj uas muaj dej nyob hauv dej. Kev nqus ntawm cov tshuaj no kuj qeeb vim tias lawv tsis soluble hauv lipids. Txawm li cas los xij, cov tshuaj no qhia tau yooj yim rau lub raum tso tawm, uas ntau dua li lipophilic statins. Cov dej-soluble statins yog sawv cev los ntawm ionized lossis polar Cheebtsam ntawm cov tshuaj. Ntxiv mus, dej-soluble statins tau yooj yim tso tawm yam tsis muaj kev hloov pauv.
Dab tsi zoo sib xws ntawm Fat Soluble thiab Dej Soluble Statins?
- Cov npe, cov roj soluble thiab dej soluble statins, sawv cev rau cov chav kawm tshuaj / tshuaj.
- Ob hom tshuaj no tau nqus mus rau hauv cov hlwb ua ntej ua qhov xav tau.
Qhov txawv ntawm Fat Soluble thiab Dej Soluble Statins yog dab tsi?
Statins yog ib pawg tshuaj uas tuaj yeem pab txo qis cov roj cholesterol hauv cov ntshav. Muaj ob hom rog soluble statins (lipophilic statins) thiab dej soluble statins (hydrophilic statins). Qhov sib txawv tseem ceeb ntawm cov rog soluble thiab dej soluble statins yog cov rog soluble statins tuaj yeem nkag mus rau hauv cov hlwb tau yooj yim thiab cuam tshuam nrog cov cell membranes, hos cov dej soluble statins qhia qhov hepatoselectivity ntau dua thiab tsis tuaj yeem nkag mus rau cov hlwb. Tsis tas li ntawd, qhov tsis yog-ionized ntawm cov tshuaj sawv cev rau cov rog soluble statins, thaum cov ionized feem sawv cev rau cov dej soluble statins.
Cov ntawv qhia hauv qab no nthuav tawm qhov sib txawv ntawm cov rog soluble thiab dej soluble statins hauv daim ntawv teev npe rau ib sab ntawm kev sib piv.
Summary – Fat Soluble vs Water Soluble Statins
Muaj ob hom statins li roj soluble statins (lipophilic statins) thiab dej soluble statins (hydrophilic statins). Fat soluble statins los yog lipophilic statins yog hom tshuaj uas soluble hauv lipids. Dej soluble statins los yog hydrophilic statins yog hom tshuaj uas yog soluble hauv dej. Qhov sib txawv tseem ceeb ntawm cov rog soluble thiab dej soluble statins yog cov roj-soluble statins tau yooj yim nkag mus rau hauv cov hlwb thiab cuam tshuam nrog cov cell membranes, whereas dej soluble statins qhia ntau dua hepatoselectivity thiab tsis tuaj yeem nkag mus hauv hlwb yooj yim.
