Qhov sib txawv tseem ceeb ntawm Swyer syndrome thiab androgen insensitivity yog qhov Swyer syndrome yog ib qho teeb meem uas cuam tshuam rau poj niam thiab yog tus cwj pwm los ntawm kev ua tsis tiav ntawm cov qog ua kua mis los tsim, thaum androgen insensitivity syndrome yog ib qho teeb meem uas tus neeg uas yog txiv neej caj ces. qhia txog kev tiv thaiv rau txiv neej cov tshuaj hormones hu ua androgens.
Swyer syndrome thiab androgen insensitivity yog ob yam kev mob ntawm kev sib deev kev loj hlob. Kev puas tsuaj ntawm kev loj hlob ntawm kev sib deev yog ib pawg ntawm cov xwm txheej uas muaj cov noob caj noob ces, cov tshuaj hormones, thiab lub cev xeeb tub, thiab qhov chaw mos. Hauv cov teeb meem no, ib tug neeg txoj kev loj hlob ntawm kev sib deev yog txawv rau lwm tus neeg txoj kev loj hlob ntawm kev sib deev. Muaj qhov tsis sib haum xeeb ntawm tus neeg lub chromosomes (cov khoom siv caj ces) thiab qhov tshwm sim ntawm tus neeg qhov chaw mos. Nws tuaj yeem ua rau muaj kev sib daj sib deev hauv menyuam mos, menyuam yaus, lossis hluas.
Swyer Syndrome yog dab tsi?
Swyer Syndrome yog ib qho teeb meem uas cuam tshuam rau poj niam thiab yog tus cwj pwm los ntawm kev ua tsis tiav ntawm cov qog nqaij hlav hauv kev sib deev. Cov neeg uas raug kev txom nyem los ntawm tus kab mob no muaj kev ua haujlwm ntawm genitalia thiab cov qauv, nrog rau qhov chaw mos, lub tsev menyuam, txoj hlab ntshav, tab sis lawv tsis muaj qog nqaij hlav (ovaries). Swyer syndrome tseem hu ua 46XY ua tiav gonadal dysgenesis. Tus mob no tau piav qhia thawj zaug los ntawm Dr. Swyer hauv xyoo 1955. Cov poj niam uas muaj Swyer syndrome muaj XY chromosomal make-up es tsis yog ib txwm XX chromosomal make-up.
Daim duab 01: Txiv neej thiab poj niam Chromosomes
Cov poj niam uas muaj Swyer syndrome muaj gonadal streaks es tsis txhob qog nqaij hlav. Qhov no txhais tau hais tias zes qe menyuam tau hloov los ntawm kev ua haujlwm tsis zoo (fibrous) caws pliav. Raws li lawv tsis muaj zes qe menyuam, cov poj niam uas muaj Swyer syndrome tsis tsim cov tshuaj hormones poj niam txiv neej thiab tsis muaj hnub nyoog. Tus mob no yog vim muaj cov noob hloov pauv tshiab, los yog nws tuaj yeem tau txais txiaj ntsig hauv autosomal dominant, autosomal recessive, X txuas lossis Y txuas yam. Qhov tshwm sim ntawm Swyer syndrome tau sau tseg ntawm 1 ntawm 80,000 yug. Kev kuaj mob tuaj yeem ua tiav los ntawm kev soj ntsuam kev soj ntsuam, fluorescence hauv situ hybridization, thiab kuaj cov noob caj noob ces molecular. Tsis tas li ntawd, Swyer Syndrome feem ntau yog kho nrog cov tshuaj hloov tshuaj hormones thiab phais.
Androgen Insensitivity yog dab tsi?
Androgen insensitivity syndrome yog ib qho teeb meem uas tus neeg uas muaj caj ces ib tug txiv neej qhia tsis kam rau txiv neej cov tshuaj hormones hu ua androgens. Yog li ntawd, ib tug neeg cuam tshuam los ntawm androgen insensitivity muaj qee yam ntawm lub cev ntawm tus poj niam. Kev hloov pauv hauv AR (androgen receptor) noob hauv X chromosome ua rau androgen insensitivity. Ua tiav androgen insensitivity syndrome muaj qhov zaus ntawm 2 txog 5 rau 100,000 tus neeg uas yog txiv neej caj ces. Cov xwm txheej no tau txais txiaj ntsig raws li X-txuas rov qab qauv. Androgen insensitivity kuj tuaj yeem tshwm sim vim qhov hloov pauv tshiab.
Daim duab 02: Androgen Insensitivity
Tus mob no tau muab faib ua ob pawg: ib nrab thiab tiav. Hauv ib feem ntawm androgen insensitivity, ib tug neeg muaj ntau yam txiv neej. Txawm li cas los xij, nyob rau hauv kev ua tiav androgen insensitivity, qhov noov thiab lwm yam txiv neej lub cev tsis tsim, thiab tus me nyuam zoo li ib tug ntxhais. Kev kuaj mob tuaj yeem ua tau los ntawm kev ntsuam xyuas lub cev, biopsying gonads, thiab kuaj cov noob caj noob ces molecular ntawm androgen receptor noob. Ntxiv mus, txoj kev npaj kho mob suav nrog kev phais, txiv neej lub mis txo qis, kho hernia, kho tshuaj hormone hloov (muab testosterone).
Dab tsi zoo sib xws ntawm Swyer Syndrome thiab Androgen Insensitivity?
- Swyer syndrome thiab androgen insensitivity yog ob yam kev mob ntawm kev sib deev kev loj hlob.
- Ob qho xwm txheej yog vim muaj kev hloov pauv noob tshiab lossis kev hloov noob caj noob ces.
- Qhov kev kuaj mob tseem ceeb ntawm ob qho tib si yog los ntawm kev ntsuas lub cev.
- Tsis tas li, ob qho xwm txheej tuaj yeem kho tau los ntawm kev kho tshuaj hormone hloov.
- Ob leeg muaj XY chromosomal make-up.
Qhov txawv ntawm Swyer Syndrome thiab Androgen Insensitivity yog dab tsi?
Swyer Syndrome yog ib qho teeb meem uas cuam tshuam rau poj niam thiab yog tus cwj pwm los ntawm kev ua tsis tiav ntawm cov qog nqaij hlav hauv kev sib deev. Cov neeg uas raug kev txom nyem los ntawm tus kab mob no muaj kev ua haujlwm ntawm genitalia thiab cov qauv, nrog rau qhov chaw mos, lub tsev menyuam, txoj hlab ntshav, tab sis lawv tsis muaj qog nqaij hlav (ovaries). Androgen insensitivity Syndrome yog ib qho teeb meem uas ib tug neeg uas muaj caj ces ib tug txiv neej qhia tsis kam rau androgens. Yog li ntawd, ib tug neeg cuam tshuam los ntawm androgen insensitivity muaj qee yam ntawm lub cev ntawm tus poj niam. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm Swyer syndrome thiab androgen insensitivity. Tsis tas li ntawd, Swyer syndrome yog vim muaj kev hloov pauv hauv cov noob xws li SRY, NROB1, DHH, WNT4, MAP3K1, thaum androgen insensitivity yog vim muaj kev hloov pauv hauv cov noob AR.
Cov hauv qab no infographic teev qhov sib txawv ntawm Swyer syndrome thiab androgen insensitivity nyob rau hauv daim ntawv tabular rau ib sab ntawm kev sib piv.
Summary – Swyer Syndrome vs Androgen Insensitivity
Kev mob ntawm kev sib deev kev loj hlob (DSD) yog cov mob nrog atypical chromosomal, gonadal, phenotypic pw ua ke. Qhov no ua rau muaj kev sib txawv ntawm txoj kev loj hlob ntawm cov kab mob urogenital thiab txawv cov tshuaj phenotypes. Swyer syndrome thiab androgen insensitivity yog ob yam kab mob ntawm kev sib deev kev loj hlob. Swyer syndrome cuam tshuam rau poj niam. Lawv muaj cov poj niam lub cev ua haujlwm, nrog rau lub tsev menyuam, cov hlab ntsha, thiab qhov chaw mos. Tab sis lawv tsis muaj zes qe menyuam. Androgen insensitivity Syndrome yog ib qho teeb meem uas ib tug neeg uas muaj caj ces ib tug txiv neej qhia tsis kam rau androgens. Yog li ntawd, ib tug neeg cuam tshuam los ntawm androgen insensitivity muaj qee lub cev ntawm tus poj niam. Yog li, qhov no yog cov ntsiab lus ntawm qhov sib txawv ntawm Swyer syndrome thiab androgen insensitivity.
