Qhov sib txawv tseem ceeb ntawm ICAM-1 thiab VCAM-1 yog tias ICAM-1 yog lub cell adhesion molecule uas tau tsim tawm hauv daim nyias nyias ntawm leukocytes thiab endothelial hlwb, thaum VCAM1 yog cell adhesion molecule uas tau nthuav tawm hauv cov membranes ntawm vascular endothelial hlwb tsuas yog tom qab stimulated los ntawm cytokines.
Cell adhesion molecules yog ib pawg ntawm cov cell nto proteins. Lawv txoj haujlwm yog khi cov hlwb ua ke nrog lwm cov hlwb lossis nrog cov matrix extracellular. Yog li ntawd, cov proteins no pab cov hlwb los ua ke thiab nyob ib puag ncig lawv. Lawv yog ib feem tseem ceeb ntawm kev tswj cov ntaub so ntswg. Ntxiv nrog rau kev ua haujlwm ua adhesion molecules, lawv kuj ua lub luag haujlwm tseem ceeb hauv kev loj hlob, tiv thaiv kev tiv thaiv, thiab apoptosis. Qhov tsis txaus ntseeg ntawm cov molecules no ua rau muaj ntau yam kab mob, nrog rau mob qog noj ntshav. ICAM-1 thiab VCAM-1 yog ob hom cell adhesion molecules.
ICAM-1 yog dab tsi?
Intracellular adhesion molecule-1 (ICAM-1) yog lub cell adhesion molecule uas tau tsim tawm hauv daim nyias nyias ntawm leukocytes thiab endothelial hlwb. Nws tseem hu ua CD54 (cluster differentiation 54) protein. Hauv tib neeg, cov protein no yog encoded los ntawm ICAM-1 noob. Nws yog qhov chaw glycoprotein. ICAM-1 tsis tu ncua tam sim no nyob rau hauv tsawg concentrations nyob rau hauv daim nyias nyias ntawm leukocytes thiab endothelial hlwb. Nws feem ntau khi rau integrins ntawm hom CD11a / CD18 lossis CD11b / CD18. ICAM-1 tseem raug siv los ntawm tus kab mob rhinovirus ua tus receptor rau nkag mus rau hauv lub epithelium ntawm cov hlab ntsws.
Figure 01: ICAM-1
ICAM-1 yog ib tug tswv cuab ntawm immunoglobulin superfamily. Qhov no superfamily suav nrog cov tshuaj tiv thaiv thiab T cell receptors thiab. Tsis tas li ntawd, cov protein no yog transmembrane protein. Nws muaj cov amino-terminus extracellular domain, ib qho transmembrane domain thiab carboxy-terminus cytoplasmic domain. ICAM-1 muaj glycosylation hnyav. Lub extracellular domain ntawm no protein conations ntau lub voj uas tsim los ntawm disulphide bonds. Lub luag haujlwm tseem ceeb ntawm cov protein no yog stabilizing cell rau kev sib cuam tshuam ntawm tes thiab pab txhawb kev hloov pauv ntawm leukocyte endothelial. Nws kuj ua lub luag haujlwm tseem ceeb hauv spermatogenesis thiab teeb liab transduction.
VAM-1 yog dab tsi?
Vascular cell adhesion molecule-1 (VCAM-1) yog ib qho cytokine-inducible cell adhesion molecule uas tsuas yog qhia nyob rau hauv daim nyias nyias ntawm vascular endothelial hlwb. Nws tseem hu ua CD106 (cluster differentiation 106). Cov cell adhesion molecule no yog cov protein uas tau muab los ntawm VCAM1 noob hauv tib neeg. VCAM-1 noob muaj rau los yog xya lub immunoglobulin domains. VCAM-1 tau nthuav tawm ntawm ob leeg cov hlab ntsha loj thiab me tom qab cytokines txhawb cov hlwb endothelial. Cov protein no yog lub cell nto sialoglycoprotein. Tsis tas li ntawd, nws yog hom 1 membrane protein uas yog ib tug tswv cuab ntawm Ig superfamily.
Figure 02: VCAM-1
Lub luag haujlwm tseem ceeb ntawm VCAM-1 yog kev kho kom haum xeeb ntawm lymphocytes, monocytes, eosinophils, thiab basophils rau vascular endothelium. Nws kuj tseem koom nrog hauv leukocyte-endothelial cell signal transduction. Ntxiv mus, nws tuaj yeem ua lub luag haujlwm hauv kev txhim kho atherosclerosis thiab mob caj dab rheumatoid.
Qhov Zoo sib xws ntawm ICAM-1 thiab VCAM-1 yog dab tsi?
- ICAM-1 thiab VCAM-1 yog ob hom cell adhesion molecules.
- Ob leeg yog calcium-yooj yim ntawm cell adhesion molecules.
- Lawv koom rau hauv chav kawm ntawm Ig superfamily cell adhesion molecules (IgSF CAMs).
- Lawv muaj extracellular domains uas muaj Ig-zoo li domains.
- Kev tsis txaus ntseeg ntawm ob qho tib si adhesion molecules tuaj yeem ua rau cov kab mob hauv tib neeg.
Qhov txawv ntawm ICAM-1 thiab VCAM-1 yog dab tsi?
ICAM-1 yog lub cell adhesion molecule uas tau tsim tawm hauv daim nyias nyias ntawm leukocytes thiab endothelial hlwb, thaum VCAM1 yog cell adhesion molecule uas tau nthuav tawm nyob rau hauv daim nyias nyias ntawm vascular endothelial hlwb tsuas yog tom qab stimulated los ntawm cytokines. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm ICAM-1 thiab VCAM-1. Tsis tas li ntawd, ICAM-1 yog coded los ntawm ICAM-1 noob nyob rau hauv tib neeg, thaum VCAM-1 yog encoded los ntawm VCAM-1 noob nyob rau hauv tib neeg.
Cov infographic hauv qab no teev qhov sib txawv ntawm ICAM-1 thiab VCAM-1 hauv daim ntawv teev npe rau ib sab ntawm kev sib piv.
Summary – ICAM-1 vs VCAM-1
Cell adhesion molecules yog cov khoom tseem ceeb hauv kev tswj cov ntaub so ntswg thiab kev ua haujlwm. Lawv yog cov cell-surface proteins. Lawv koom nrog hauv kev sib txuas ntawm cov hlwb nrog lwm cov hlwb. ICAM-1 thiab VCAM-1 yog ob hom cell adhesion molecules. ICAM-1 yog constitutively qhia nyob rau hauv daim nyias nyias ntawm leukocytes thiab endothelial hlwb, thaum VCAM1 yog qhia nyob rau hauv daim nyias nyias ntawm vascular endothelial hlwb tsuas yog tom qab stimulated los ntawm cytokines. Yog li, qhov no qhia txog qhov sib txawv ntawm ICAM-1 thiab VCAM-1.
